LncRNAWiki is a wiki-based, publicly editable and open-content platform for community curation of human long non-coding RNAs (lncRNAs), viz., a community-curated lncRNA knowledgebase. Unlike conventional biological databases based on expert curation, lncRNAWiki harnesses collective intelligence to collect, edit and annotate information about lncRNAs, quantifies users' contributions in each annotated lncRNA and provides explicit authorship to encourage more participation from the whole scientific community.
Imagine a world in which every single person on the planet has free access to the sum of all human knowledge. — Jimmy Wales, Founder of Wikipedia
- Featured lncRNAs: 633 lncRNAs with publications have been collected and curated in LncRNAWiki over the past two years, and there are 719 featured lncRNAs in total in the present version. Among the 719 lncRNAs, 289 are extensively studied and experimentally proved to be associated with cancer or other human diseases. Newly featured lncRNA:AATBC,ABALON, APOA1-AS, APTR, BANCR, BDNF-AS, BLACAT1, BPESC1, CAHM, CASC8, CCAT1, CCAT2,CISTR, CRNDE, CYYR1-AS1, DALIR, DANCR, DBET, DHRS4-AS1, DLEU1, DLEU2, ERICD, ESRG, FENDRR, FIRRE,FOXCUT, FTX, GHET1, GHRLOS, GPR1-AS, HAGLR, HEIH, JADRR, KANTR, LINC-PINT, LINC00163, LINC00312, LINC00850, LINC01191, LSINCT5, LUCAT1, MIR22HG, MIR31HG, MIR99AHG, MIR100HG, MIR155HG, MIR222HG, MIR503HG, MYCNUT, NAMA, NRIR, OVAAL, PACERR, PART-1, PAUPAR, PCA3, PCAT1, PCAT4, PCAT7, PRNCR1, PTCSC2, PTCSC3, PVT1, PWRN1, PWRN2, RASSF1-AS1, SCAANT1, SCHLAP1, SENCR, TARID, WFDC21P (see more)
- Small proteins:Considering the potential functional significane of lncRNA-encoded small proteins(Anderson, D.M. et al.Cell,2015; Nelson, B.R. et al. Science, 2016), we developed computational approaches for automatic identification of small proteins in 105,823 human lncRNAs. As a result, we obtained 9,390 small proteins based on protein instability, secondary structure and transmembrane helix. Among the 9,390 small proteins, 2,246 transmembrane proteins are considered to be with high confidence. Accordingly, LncRNAWiki integrates all putative small proteins, their physical and chemical parameters, secondary structures, transmembrane helices and topology structures (lncRNAs and small proteins, help). We also provide download of all the information of predicted small proteins (see Downloads).
- BLAST lncRNAs: If a lncRNA is newly reported in a published paper but is not found in LncRNAWiki after BLAST, please consider to create a new page for this lncRNA to obtain its authorship in LncRNAWiki. See here for help.
- Community curation: Community-curated efforts are quantified and rewarded by giving explicit authorship. Please share your expertise and perform curations to have the authorship for lncRNAs of your interest.