IGF2-AS

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IGF2-AS, a transcript that is antisense to IGF2, acting as a regulating noncoding RNA. [1].

Annotated Information

Approved Symbol

IGF2-AS

Approved Name

IGF2 antisense RNA

Previous Symbols

IGF2AS

Synonyms

PEG8, IGF2-AS1

Chromosome

11p15.5

RefSeq ID

NM_016412

OMIM ID

610146

Ensembl ID

ENSG00000099869

pubmed IDs

10731720

Characteristics

Human PEG8/IGF2AS appears to be transcribed from the region between human IGF2 exon 4 (corresponding to mouse exon 1) and exon 4'(no corresponding exon in the mouse) in the opposite direction to the IGF2 transcript [2]. Human PEG8/IGF2AS has an open reading frame encoding a putative protein consisting of 273 AA [2]. IGF2-AS is a ubiquitous transcript, found in normal tissue, as well as neoplasms [1].

Function

Product of this gene functions as a growth factor therefore IGF2 is the best candidate for gene responsible for Beckwith-Wiedemann syndrome. [2].

Regulation

The role of the human IGF2-AS is unknown, and it is not clear how the transcript is regulated in vivo. [1]

Expression

High expression of PEG8/IGF2AS has been detected in Wilms' Tumor samples, whereas very low or almost no expression has been observed in the normal kidney tissues neighboring the tumors [2].

Evolution

Human PEG8/IGF2AS exhibits about 50% homology with mouse Igf2as (Peg8) but lacks an apparent tandem repeat in the middle part [2].

Diseases

  • Wilms' Tumor [2].
  • Beckwith-Wiedemann syndrome [2].
  • colon cancer [1].

Labs working on this lncRNA

  • Gene Research Center,Tokyo Institute of Technology,4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501 [2].
  • Medical Service, VA Palo Alto Health Care System and the Department of Medicine, Stanford University School of Medicine, Palo Alto,California 94304, USA [1].
  • Department of Food and Nutrition, Japan Women’s University, Tokyo 113, Japan [1].

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Cui H, Horon IL, Ohlsson R, Hamilton SR & Feinberg AP. Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability[J]. Nature medicine. 1998, 4:1276.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Okutsu T, Kuroiwa Y, Kagitani F, Kai M, Aisaka K, Tsutsumi O et al. Expression and Imprinting Status of Human PEG8/IGF2AS, a Paternally Expressed Antisense Transcript from the IGF2 Locus, in Wilms' Tumors[J]. The Journal of Biochemistry. 2000, 127(3):475-483.

Sequence

>gi|98986326|ref|NM_016412.2| Homo sapiens insulin-like growth factor 2 antisense (IGF2AS), mRNA

000001 CGGAGTCCTA GGCCCGCGGG CTAGAGGCAC TTTACCGCCC GGCGGGAGCG CCTCTCCTCC GCGTCCCTCG CCCCAGCCCC 000080
000081 CTGCCCGCCC CACTTTGGGA CCCTCCAGCC GCTTTCCCCA CAAATGAGAT CTTTGCAATG AGCAAACGAA AGTGGCGCGG 000160
000161 ATTTCGGGGC GCCCAGCAGG AGCGAGCGCA GCCGCCAGCC GCAAGTCCGC AGCCGTGTCC CGCGCCCCAC GCCGGCCTCC 000240
000241 CCGGCGGCAG CCGGAGACGA GCGCCAGCAC CGGCGGGACA GCAGCAGATG CGGGCCGAGA GCCGGTCAGG GGCGCAGAGG 000320
000321 CGGAGGGGAT CGGCGCGGCG GGGAGCTCAC CGCGAAGCTG GAGGCTGCGT CCGCGGGCGC ACCAGGAGCT CAGGCAGCGA 000400
000401 GCGATCGAAC GCTCTGTGGC AGGCGGTGGA CGCTGCTGAA GCTCTGGCTC TGAGCTCACC GCTCCGCCGT CCGTGGGACC 000480
000481 AAGCCCAGCA TTTTACAAAC CCAGCTCCTT TCTCCAAGGG TCCTCAGAGC GCCCCTCCGT CACCCCCTGC AGGGCGCCGC 000560
000561 AGACGAGGCG CTGACCTTGC GCTCACTCCC CTCGCTGGGG AAGGACACAC TCGCTGGCGT CAGCCCGGCC GGCCTGGGAA 000640
000641 GTAGGACTAA GGACCCGAAC TGCAACCCTC CACACCAGAC AGCACAGACC ACCCCAAGGC TGCTCAATCT GCCCAAAGCC 000720
000721 AAAAGAGCTC CCCTGCCAGG ACCTCGGTGC CGTGGAGACT GCGGGGAACC TGCTCTGCCC ACACCTGCTC TGGCCCCTAG 000800
000801 ACGGAAGCAC CTGGAGCCAA CCACGGAACT CCAGATCCCA GCTGTGTGAC TGAATCCACG CCAGCCTCTC TGAGCCAAAG 000880
000881 CTGCTTGCAG AAGGGGGAGA TCCCAGTTCG AAGACTCCCG CGCAGAGCCT GTGGCCCTCT CTGCCAGGCC TCAGGGTGCC 000960
000961 TGAGACACTC ACCTCTCTGC CTCGCAGTTG GGGCTGAGGC TGGGGCTGGC TGCCAGCCTC AGTTCTGGGA GCGCTGGGGT 001040
001041 CGCCTGGGCC ACAGGCCACA GCAGCTCACC TCAGGACTGG GCTCTCTGGC CTGCTGGGGC TCAGGCTGTG GGGCAGGCTG 001120
001121 GGCAGGGGGC TGAGCTGGCA GCGATTCAGA GCCCTGGGGC TGGGGGCTGG AATCCACCTC CTCCCACACA AGCTCGGTGG 001200
001201 TGACTCTTCG GCCCCTGGGG AAAAACAAAA AGATATTGCT GAGATGACCT CTTTTAAAAG CAAAGCCCCC CTCCCCATAC 001280
001281 ACCCCAAGCC TGAGCCCTGT CCCATCCCCC TCCCCGGGTT CCTTCAGGTC ACCTTGTCAG GATCTGGGCA GCGGCTTCCC 001360
001361 CCTCTAGCCC CTCCCCTGCC TAGAGCTCCC TCTTTCAAAG TATAAGGGAG GGAAGAAGTG GTGAGAAGTT TGCCTAGAAA 001440
001441 GGGCTTCCCG GTGCTGATGG AGAGGCCGAG ACCCTTCTGT TGGACAGGCT GCCCTGTTCC TGGGTGAGGA TGGGCTTCTG 001520
001521 CCTGGCACTG GGGGTGGAGG GTGCACACGA ATGGCCCGCC TTGAGGGGTC ATGGCACGGA ATATGAAAGC CTCCTCCACC 001600
001601 TCCAAACACC CCCACCTTGG AAGGAGATAA GGAGGGGGCC CCAGCAAAAG CCACTGGACA CACAGCTCTG CTTGACGAGG 001680
001681 CCAGTGAGGG ACGGCGTGGC TGTGCTTCCT GGGGAAATGA ACCCCCTCCC CACAGACACC ACCCTGGGTG GATCGAGGAG 001760
001761 TCTGGGTCCA GGGTGCAACA GAGAAAAACT TCATGCATGA ATGAGCATTC CCAGGGAAAC TGCCTTGGCC CCAGGGCGCC 001840
001841 TCTCTGTGCC AGGGAGGCTG GGAGAGCAGC AAGGGGGACC AGGTGCGCCA TCAGGAGGAG AGAAGCTAAA CCTAGGGGGG 001920
001921 ACATGGAGGG CGGTTGTTGC CTCTCCCGGC ATTTCTCCTC AGTCTCCTGT CCAATTTCTT GCTGGTGGTC AGGAGGCATA 002000
002001 GGGAGGCAGG AGGGAAGGAA GCTTTACCTG TAAAATGGTG TATATATGTA TAAATAAAAT CTCTGCGCCA G