Approved symbol: TRPM2-AS
Approved name: TRPM2 antisense RNA
HGNC ID: HGNC:50758
Alias symbols: TRPM2-AS1
RefSeq ID: NR_109964
Ensembl ID: ENSG00000230061
LncBook ID: HSALNT0289414
The CpG island could be involved in the transcriptional regulation of TRPM2-AS,specifically,the methylation status of the CpG island contributes negatively to the expression level of both TRPM2-AS.
TRPM2-AS transcripts is up-regulated in melanoma, and their activation is consistent with the methylation status of the shared CpG island. Tumor samples displayed higher levels of TRPM2-AS and TRPM2-TE transcripts with respect to their matched normal tissue. 
lncRNA TRPM2-AS possibly regulated cell cycle, apoptosis, and resistance to anti-tumor drugs of carcinoma cells via suppressing p53-p66shc pathway in NSCLC.
Labs working on this lncRNA
- DIBIT-San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy. 
- Respiratory Department, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing, China.
- Orfanelli U, Wenke AK, Doglioni C, Russo V, Bosserhoff AK, Lavorgna G.Identification of novel sense and antisense transcription at the TRPM2 locus in cancer. Cell Res. 2008 Nov;18(11):1128-40. doi: 10.1038/cr.2008.296.
- Ma LY, Xie XW, Ma L, et al. Downregulated long non-coding RNA TRPM2-AS inhibits cisplatin resistance of non-small cell lung cancer cells via activation of p53- p66shc pathway[J]. Eur Rev Med Pharmacol Sci, 2017, 21: 2626-2634.
>gi|568786345|ref|NR_109964.1| Homo sapiens TRPM2 antisense RNA (TRPM2-AS), long non-coding RNA