SMILR (smooth muscle induced lncRNA, enhancer of proliferationas) is a long noncoding RNA that is used as a driver of vascular smooth muscle cell proliferation and consider as a novel therapeutic strategy to reduce vascular pathologies.
SMILR: Smooth muscle induced lncRNA, enhancer of proliferation (HGNC nomenclature), RP11-94a24.1 
SMILR is four exon transcript of 569 bp long noncoding RNA that is located on human chromosome 8q24.13, ~750 kbp downstream of HAS2 on the same (reverse) strand and ~350 kbp from ZHX2 and ~750 kbp from HAS2-AS1 on the opposite strand of chromosome 8 . The longest open reading frame(ORF) within SMILR is 57 amino acids .
SMILR is located in both nucleus and cytoplasm .
SMILR is expressed highest in heart . It is differentially expressed in human saphenous vein-derived smooth muscle cells following stimulation with interleukin-1α and platelet-derived growth factor . Increased expression of SMILR is observed in unstable atherosclerotic plaques, and plasma from patients with high plasma C-reactive protein .
SMILR expression is dysregulated in unstable human carotid plaques .
SMILR expression can be regulated by IL1α or PDGF and it is a time-dependent manner .
- Cardiovascular disease
Labs working on this lncRNA
- BHF Glasgow Cardiovascular Research Centre, University of Glasgow, United Kingdom
- British Heart Foundation/University of Edinburgh Centre for Cardiovascular Science, Edinburgh, United Kingdom
- Ballantyne, M.D., Pinel, K., Dakin, R., Vesey, A.T., Diver, L., Mackenzie, R., Garcia, R., Welsh, P., Sattar, N., Hamilton, G. et al. (2016) Smooth Muscle Enriched Long Noncoding RNA (SMILR) Regulates Cell Proliferation. Circulation, 133, 2050-2065.
>gi|105375734|ref|NR_131202.1| Homo sapiens smooth muscle induced lncRNA, enhancer of proliferation (SMILR), long non-coding RNA