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SNHG4: Small nucleolar RNA host gene 4
Upstream from the Matrin 3 protein coding gene. A number of splice isoforms of SNHG4 exist, some of which join Matrin3 and so act as an upstream initiation site for Matrin 3.
SNHG4 specific isoforms appear to contain the first four SNHG4 exons and differ at the 3' end.
Contains U19 snoRNA in intron 3 (annotated as SNORA74A in Refseq).
Transcriptional start site has characteristics of the 5' TOP gene family.
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Expressed in a number of adult human tissues.
Shows a nucleoplasmic localisation. In constrast to other SNHG RNA (SNHG1, SNHG3) which are localised in the cytoplasm.
Human SNHG4 isoforms 1&2 were highly stable in B cells (half-life >8 hr), while mouse Snhg4 was highly unstable in mouse 3T3 cells, suggesting differential stability between species (Friedel (2009), Clark (2012)).
Likely present in mouse with same relationship with Matrin 3
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Allelic Information and Variation
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Labs working on this lncRNA
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