NONHSAT087635

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Annotated Information

Name

Approved symbol: EGOT

Approved name: eosinophil granule ontogeny transcript

HGNC ID: HGNC:37129

Previous names: eosinophil granule ontogeny transcript (non-protein coding)

Alias symbols: EGO; NCRNA00190

Alias name: eosinophil granule ontogeny; non-protein coding RNA 190

RefSeq ID: NR_004428

LncBook ID: HSALNT0288940


Characteristics

Two isoforms: ~1.0kb unspliced EGO-A and ~1.5 kb spliced (two exons) EGO-B.

Transcribed antisense from a conserved intron of ITPR1 gene.

Function

Proposed to affect myeloid development by regulating eosinophil gene expression, as knockdown of EGO in vitro in CD34+ cells decreases eosinophil granule protein MBP (major basic protein) and EDN (eosinophil derived neurotoxin) mRNA levels.[1]

Regulation

Please input regulation information here.

Expression

Highly expressed in human bone marrow CD34+ cells and BMMC (bone marrow mononuclear cells). Highly upregulated during eosinophil development from CD34+ human hematopoietic stem cells before returning to basal levels within 72 hours. Despite a return to basal levels, EGO transcripts were present and inducible in mature eosinophils.

Conservation

EGO and some of surrounding sequence is conserved. However the presence of EGO has not been investigated outside of humans.

Evolution

The whole EGOT locus contains several evolutionary conserved, and thermodynamic stable secondary structures. The spliced isoform, EGO-B, is highly conserved and may be present throughout the placental mammals.[2]

Disease

breast cancer[1]

Labs working on this lncRNA

  • Bioinformatics Group, Department of Computer Science, University of Freiburg Freiburg, Germany.[2]

References

Annotation originally sourced from lncRNAdb.

  1. 1.0 1.1 Xu, S.P., Zhang, J.F., Sui, S.Y., Bai, N.X., Gao, S., Zhang, G.W., Shi, Q.Y., You, Z.L., Zhan, C. and Pang, D. (2015) Downregulation of the long noncoding RNA EGOT correlates with malignant status and poor prognosis in breast cancer. Tumour Biol, 36, 9807-9812.
  2. 2.0 2.1 Rose, D. and Stadler, P.F. (2012) Molecular evolution of the non-coding eosinophil granule ontogeny transcript. Front Genet, 2, 69.

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Basic Information

Transcript ID

NONHSAT087635

Source

NONCODE4.0

Same with

,

Classification

intergenic

Length

1529 nt

Genomic location

chr3-:4790876..4793274

Exon number

2

Exons

4790876..4791694,4792630..4793274

Genome context

Sequence
000001 caacttctgg gcaaggcaga ggtgggtttg gctttttaaa aattttttca gcctgtcctc atggaactac atattctttt 000080
000081 ctaagaactt ttcatcctaa cctccctact cacatcttct aagtgtctct gctctggtgg gaatgtgatg gacaacacag 000160
000161 agccatctca gaagcctctg tggccaccac caggccggcc agggtgcagg gggccactcc ctgggcagcc atagggttct 000240
000241 cagcaaggtg cattcgtcgt ccctgctgag aatctgatgg ggcagcattt ttttttttaa ttaaatgcaa gctgagtcat 000320
000321 ttcaacctgc aaccttcagg taacaggagt tacccaagct ccaggaatta tgattgtggg gtaaacccat tctcttgttt 000400
000401 tcttgcggtt ctattttata acgcactaga ggagacagag acgtcattgc ttcacccagg gcaagaggac aaaggaggat 000480
000481 gcatggaaat acaaacagcc cttctcctcc aggccatacc gactgtccaa ctagcaacag acttcacctg gttttggagc 000560
000561 aatctgaatt tggaatatgc cagagaaaac ttctatcagg caagatggaa gactcctagg ataggtctct ctcatggagg 000640
000641 gattggcacg atggtaagag tccagtggat ggaaaaggcc tcctccttaa agatggtgat ggaaacgagc actgcacagg 000720
000721 gaaacacaaa tcaggtcccc tgaaatccag cccaacctgg ccagaccctc cagtgcccat cagggcttat gaacagggtg 000800
000801 cttcagtgtc tttgttaggg gtggttaaaa aggagcacgt gcttataggg gatgctgctg agctccatga ttttgacttc 000880
000881 ctgtctaacc tgttgatgct acaaaactct tttaaaaaca gttaccatgg gaacttttcc ctagcaagca ttcttcaaga 000960
000961 aacgttacag gtgctggtga attcaatgcc cttggtgtca ataagctttt gctgagtctt agaatgtgtg gcttgaactg 001040
001041 agaggacttt caaacagata atgcgaagtt tccaatgcaa atgtcttcgg ggttaagtgt cagtgaagtg cagtggaagg 001120
001121 tagggggata aaatgatctc agtgtatatg gaggccccac ttaagcattc aaaaaattct atatacagtg ttttcaatgt 001200
001201 attatgtatc agcaaaacaa aataccccat agggctataa tcagctcagg gggtcacctc agcaagagat gctctggcta 001280
001281 tcactcctac tacgggattt cctctctcat cagaaccagt aggtggtcaa aaccacaata atgcataaat gaaggcaggg 001360
001361 aattgggtat ccaatgtgag caactgaaaa ggtgccatgt attagctatt tgccattatg gttctgcaag tgctcagatg 001440
001441 actcataaaa tgaccagaac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 001520
001521 aaaaaaaaa
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[XfH-AQ-4pCzxm0RzYvUqxQAAAAQ] 2019-12-12 08:49:08: Fatal exception of type "TypeError"

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