NONHSAT081499

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MIR155HG, a 1500 bp long non-coding RNA transcribed from BIC(B-cell integration cluster).

Annotated Information

APPROVED SYMBOL

MIR155HG

SYNONYMS

"B-cell receptor inducible", BIC, "BIC transcript", NCRNA00172, "non-protein coding RNA 172"

Characteristics

MIR155HG, encoding a 1500 bp non-coding RNA, is comprised of three exons and locates in cytoplasm.[1]

Cellular Localization

  • Cytoplasm

Function

MIR155HG, as a T cell early activation proto-oncogene, might act to alter the genetic program, such that upon antigen re-stimulation.[2]

Regulation

(A) Schematic representation of the human MIR155HG with the transcription factor binding sites which have been shown to regulate the expression of this gene which have been localized downstream of exon 1. (B) Schematic representation of the transcription factor binding sites which have been shown to regulate the expression of MIR155HG which have been localized upstream and just downstream of exon 1. The black arrow in exon 1 denotes transcription initiation. The light blue shaded area represents a CpG island. TATA represents the location of the TATA box for MIR155HG.[1]

MIR155HG promoter may be activated by both AP-1- and NF-κB-mediated mechanisms upon B-cell stimulation[1].

Diseases

  • B-cell chronic lymphocytic leukemia, Breast cancer [3]

Expression

MIR155HG expression is highly induced by antigen receptor stimulation of B-cells (i.e. B-cell receptor cross-linking) [3]

Labs working on this lncRNA

  • Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA.[1]
  • First Faculty of Medicine and Center of Experimental Hematology, Charles University in Prague, Prague, Czech Republic.[3]
  • Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA.[2]






References

<references> [3](1) [1](2) [2](3)

Basic Information

Transcript ID

NONHSAT081499

Source

NONCODE4.0

Same with

MIR155HG, BIC

Classification

intergenic

Length

5409 nt

Genomic location

chr21+:26934386..26951344

Exon number

3

Exons

26934386..26934569,26942149..26942233,26946205..26951344

Genome context

Sequence
000001 CTGGTCGGTT ATGAGTCACA AGTGAGTTAT AAAAGGGTCG CACGTTCGCA GGCGCGGGCT TCCTGTGCGC GGCCGAGCCC 000080
000081 GGGCCCAGCG CCGCCTGCAG CCTCGGGAAG GGAGCGGATA GCGGAGCCCC GAGCCGCCCG CAGAGCAAGC GCGGGGAACC 000160
000161 AAGGAGACGC TCCTGGCACT GCAGATAACT TGTCTGCATT TCAAGAACAA CCTACCAGAG ACCTTACCTG TCACCTTGGC 000240
000241 TCTCCCACCC AATGGAGATG GCTCTAATGG TGGCACAAAC CAGGAAGGGG AAATCTGTGG TTTAAATTCT TTATGCCTCA 000320
000321 TCCTCTGAGT GCTGAAGGCT TGCTGTAGGC TGTATGCTGT TAATGCTAAT CGTGATAGGG GTTTTTGCCT CCAACTGACT 000400
000401 CCTACATATT AGCATTAACA GTGTATGATG CCTGTTACTA GCATTCACAT GGAACAAATT GCTGCCGTGG GAGGATGACA 000480
000481 AAGAAGCATG AGTCACCCTG CTGGATAAAC TTAGACTTCA GGCTTTATCA TTTTTCAATC TGTTAATCAT AATCTGGTCA 000560
000561 CTGGGATGTT CAACCTTAAA CTAAGTTTTG AAAGTAAGGT TATTTAAAAG ATTTATCAGT AGTATCCTAA ATGCAAACAT 000640
000641 TTTCATTTAA ATGTCAAGCC CATGTTTGTT TTTATCATTA ACAGAAAATA TATTCATGTC ATTCTTAATT GCAGGTTTTG 000720
000721 GCTTGTTCAT TATAATGTTC ATAAACACCT TTGATTCAAC TGTTAGAAAT GTGGGCTAAA CACAAATTTC TATAATATTT 000800
000801 TTGTAGTTAA AAATTAGAAG GACTACTAAC CTCCAGTTAT ATCATGGATT GTCTGGCAAC GTTTTTTAAA AGATTTAGAA 000880
000881 ACTGGTACTT TCCCCCAGGT AACGATTTTC TGTTCAGGCA ACTTCAGTTT AAAATTAATA CTTTTATTTG ACTCTTAAAG 000960
000961 GGAAACTGAA AGGCTATGAA GCTGAATTTT TTTAATGAAA TATTTTTAAC AGTTAGCAGG GTAAATAACA TCTGACAGCT 001040
001041 AATGAGATAT TTTTTCCATA CAAGATAAAA AGATTTAATC AAAAAATTTC ATATTTGAAA TGAAGTCCCA AATCTAGGTT 001120
001121 CAAGTTCAAT AGCTTAGCCA CATAATACGG TTGTGCGAGC AGAGAATCTA CCTTTCCACT TCTAAGCCTG TTTCTTCCTC 001200
001201 CATATGGGGA TAATACTTTA CAAGGTTGTT GTGAGGCTTA GATGAGATAG AGAATTATTC CATAAGATAA TCAAGTGCTA 001280
001281 CATTAATGTT ATAGTTAGAT TAATCCAAGA ACTAGTCACC CTACTTTATT AGAGAAGAGA AAAGCTAATG ATTTGATTTG 001360
001361 CAGAATATTT AAGGTTTGGA TTTCTATGCA GTTTTTCTAA ATAACCATCA CTTACAAATA TGTAACCAAA CGTAATTGTT 001440
001441 AGTATATTTA ATGTAAACTT GTTTTAACAA CTCTTCTCAA CATTTTGTCC AGGTTATTCA CTGTAACCAA ATAAATCTCA 001520
001521 TGAGTCTTTA GTTGATTTAA AATAATTTTT ATGGCCCATT TTCTTTTGCA AAGTACAAAT TATAATTCCA GAAGCTATCT 001600
001601 GCCAAAAAAA GACAATGGAA GAAAATTATG AGGACACTAA AGGGAACATT CCTGACTCCT AGGACACAGT ATTCTCATGT 001680
001681 AAGAATACCC ATTTGGCTTT GCCCCACTTT CTGTTCAAGT TGTATGTGCT GCCAAGACAA ATTTCTTCTC CTCACTTTCT 001760
001761 GTTCAAGTTG TATGTGCTGC CAACACAAAT TTCTTCTCCT AACACCTGGA ATGAGCTTGT GGCTCCACGG AGCTCCCATG 001840
001841 TAGGTAGAAC ACATTCAAGA GTGTTTCTTC AGGCCAGGCA CAGTGGCTCA CGCCTATAAT TCCAACACTT TGGGAGGCCA 001920
001921 AGGCGGGTGG TTCACTTGAG GTCAGGAGTT CTACACTACC CTGGCCAACA TAGTGAAACC TCGTCTCTAC TAAAAATACA 002000
002001 AAAATTAGCT AGGCATGGTG GTGCGTGCCT GTAATCCCAG ATACTCAGGA GGCTGGGGCA GAAGAATCAC TTGAACCCAG 002080
002081 GAGGTGGAGT TCACAGTGAA CGAAGATCGT GCCACTGCCC TCCAGCCTGG GTGACAGAGT GAGACTCCAT CTCAAAAAAA 002160
002161 AAAAAAAGTG TCTGTTCAAT TCATTTTATC TGCCACTGTA TATCTACAAG AGGACTCCTT GCTTTGAGTC CCAGTTCTTC 002240
002241 AAAATCCTGC TTGCTGCCTA AAGACACAAA GTCATAGAAC ATTAGGACTG GAATAAACTA TTGTAGTATA ACCTTCCTGC 002320
002321 TGTTACAATA AAAAGCTATA AACATTACAA AGGCACTTAA AGAAAAGCTG TGCTGGGAAA TGCCTTATTT GAAGAGCATT 002400
002401 TGGGTACACT CACATGAAGC TTTGGAAAGT TACTTAATCT TCCTCTAAGC CTCAATTTCT TCATCAATAA AATGATGAAT 002480
002481 ATATTTCATA TTTCATAAGA TGTAGGCTTA AATGAAATCA TGCATGTGAA AAGCACAATG TCTATTATGC ATTAAGTGTT 002560
002561 AAACACAAAC TTTCAAACTT TTACATTTCA GTCATTTAAA TCAAATGATC TACCATAGCA GATCTCCCCA AAGACACTCT 002640
002641 AGCTCCAAAC TAACTATAAT CAATCCCGTG GTGACGACCC AAAGAACCAG GGTTCCTGGG TTTTCTCTCA CGCCCAGCCC 002720
002721 ACCTAGGCTT CTGACTGCCT ATCTCCTCAT CTTAGAGGGA TTCCTCCTGA CCAGTCATTA CAAAAATTCT TGGAGCATGA 002800
002801 GCAAGACTGA GTCTGTGTTT GGATTGGAGG AAGGGGTAAG TAACAAGGTA TATATATGTA TATGTGTGTG TGTGTGTGTG 002880
002881 TGTGTGTGTG TGTGTGTGTG CGCGCGCGTT TGTGTTTAAG TTACAAACTA AGGATGGTTT TAAAAAATTG CAAAATGTTA 002960
002961 AGAGATTTAT CTAGGATCTG ACCCACTTCC CCAGAAATTT ACGGAATTCA AGACCAAGCC TTTCGTATTC ACTGTCATCA 003040
003041 GTTAGATGGA CCCAGTAGCT AAAAAATTAA GGAGAAAAAA AATAGAGGAA TATGAGGGAA AAAGTCAAGT CAGAGGACTG 003120
003121 AAGAATATAT ACAGAACATA GAATATTAGA AATTTTCTGA AAATAGATGA TAGCAAATAC CTCAAGAAAG TGAGGAAACG 003200
003201 TGAAAAGGGA GCTTAAAGAA AAATAATAGA GTCCATACAT GGGACACAAG CACAAAAAGC TGACTGAGCA TGTGGTTCTC 003280
003281 TACTAATAAT AACTGGAAAA CAGTGAAACC AGCAGGAAAA ACTTGCACAT AAGAGTTTAA CTTTCCACTT TGGGTTTCAA 003360
003361 ATTCTCCCAT AGCAATAAGA GTAAGTGAAA TAATGTTCAC ATAAGGATTT TTTTTTTTTC TATTACTGTA GTGTTTTGTT 003440
003441 TTGTTTTGTT TTGGTTTTGG TTTTTGGTGG TTTTTTTTTT TTTGAGACAA AGTCTCGCTC TTGTCCCCCA GTCTGGAGTG 003520
003521 CAATGTCATG ATCTTGGCTC ACTGCAACCT CCGCCTCCCG GGTTCAAGTG ATTCTCCTGC CTCAGCCTCC CAAGTGGCTG 003600
003601 GGATTACAGG TGCGTACCAC CACGCCCAGC TAATTTTTTG TATTTTAAGC AGAGACGGGG TTTCACCATG TTGGCCAGGC 003680
003681 TGGTCTCGAA CTCCTGACCT CAGGTGATCC ATCCATCTCA GCCTCCCAAA GTGCTGGGAT TACAGGTGTG AGCCACCGCA 003760
003761 CCCGGCCTGT TACTGTAGTG TTTTAACAAA TCTAAGTGTA ATAGTATTAG TCTTCATTCA TCTAAGACAT ACAAGTACTG 003840
003841 GAATTTTTTA GGTGGGTTCC TCAAATGTCA TCACAGTGGT GTCTTCTCTA CATTCAGTCA CTCTTCCGCC CTTCTCTGTA 003920
003921 ATGCTCAGGG ATTTCCCAGT TCACTAGCAC TTAACATAGT ATGTCCTTAC TTACTTTGGG GTATAAATGA CTGCAATAGA 004000
004001 AGAAGTGATA TCCTTGAGGG ATGAAACACG ATCTTGCATA TTCATATCCC TTTCAAATGT TTACTGACTT AATCACACCA 004080
004081 TTAGTTTTCT AAGTCCAAGT CTAAAAACAG AAATGAGTTT AAATACAGTG AACATTTCAT TTTCACTATA CCACTAAGCT 004160
004161 GAAAGAAATG ATTTTTGGTA AATAAAAGTT CATCACAGTG AAAAGTTCTA CATATAACTG AAGATCAAAG GATTCTCACC 004240
004241 TGGGAAGCTT GTCAAGATGC ATGTTCCCAA GCTCCCAGGC TCCCACTCCC AGAGATTCTA ATACTGTAAT GGAGCTGAGG 004320
004321 ACACTACATT TTTAACAGGC TGACCAGGTA GTTCAGATTC AGGTGGTTCC TAAACCAACT CTGAGGAAGT AGTGGTTTTA 004400
004401 TATACGATGC TACTGTTGAT GTGGCTACTA GGAATGGTGC TCAGCAGAAA TCCTGCAACA TATGGATCTG TTTACACACT 004480
004481 ATTCACTGTG TAATGAGAGT CTGCAACATA GGCTAAGTAA TAAGAGATGT CTTGTGGTTG ACCTCTCTGG AGATAAGCAG 004560
004561 CAATGAAATT CCAATGAAGT TTCATCATCT CTCATCACCA AAACCATCCT AACCACCTCA ATAAAATACA CCTGACTTCC 004640
004641 CCCGCTCCCC CGACCCACCA CCCCAAAACC AGCTGCCCTA TGTTCTACCA AAAGCTGCAA CCAACCAATG ACCTGATACT 004720
004721 AACCCCAATC TATCAGCTGC TGCCTAGTGC AACAGAGAGG GAAAGTCAAT GAGAAGGAAT TGGGTGCCAG TTCTTGCTTT 004800
004801 GCAAGGAGTG GGTTGACTAA TGAGACAGCC ACAAATGTCA CTGCCATCCC ATCTCACCCT TTCACCTGTG CTGCAAGGCT 004880
004881 TCAACAATCA TACCCAGTCT CCACTTAGGA AAATTCTGTC CTTTCTCAAA TGCTGGCCAC TCAGCAATGT GCTCCCTTAA 004960
004961 TCCAGGCCAA GCACATAGTA AAAGAACTCC AAAAAGGGTT ACAGCCAAAA GTGATCTTTC TCCTCCATAC TCCCAAAGCA 005040
005041 GATTATAGCT CCTCCATAAA CGTGCTTCGC ATTGTGCCCC ACGTTTGGTT TGTTACTTGT GTATACATTA TCGTCTCTTC 005120
005121 TAGATTGAGC TTCTGTAGGA AAGGAGAATC CTTTTCAATT TTTTGGTATT ACACCCAGCT CAGGACCTTG CTCAGTTGCT 005200
005201 TAAATTGAAT GAGAAAATGT ATCTAAGTAC CCACTGATGT TGGAAATTCA ACTTGTTCCA ATATTGAGGA CTGCCTATAC 005280
005281 CTGGCATATG CGTGTCCCAA TTTGAGAAAT TGTTTTTCAA GTTGACTTGT ATGGATTCCT TACAGACGCT CAAGCATCAG 005360
005361 TTTGGTTTTC CCTAAATCCT GCAGATCAGG AAGGCAGTAT CCATGTTTG
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  1. 1.0 1.1 1.2 1.3 1.4 Elton, T. S., H. Selemon, S. M. Elton, and N. L. Parinandi. "Regulation of the Mir155 Host Gene in Physiological and Pathological Processes." Gene 532, no. 1 (2013): 1-12.
  2. 2.0 2.1 2.2 Haasch, D., Y. W. Chen, R. M. Reilly, X. G. Chiou, S. Koterski, M. L. Smith, P. Kroeger, K. McWeeny, D. N. Halbert, K. W. Mollison, S. W. Djuric, and J. M. Trevillyan. "T Cell Activation Induces a Noncoding Rna Transcript Sensitive to Inhibition by Immunosuppressant Drugs and Encoded by the Proto-Oncogene, Bic." Cell Immunol 217, no. 1-2 (2002): 78-86.
  3. 3.0 3.1 3.2 3.3 Vargova, K., N. Curik, P. Burda, P. Basova, V. Kulvait, V. Pospisil, F. Savvulidi, J. Kokavec, E. Necas, A. Berkova, P. Obrtlikova, J. Karban, M. Mraz, S. Pospisilova, J. Mayer, M. Trneny, J. Zavadil, and T. Stopka. "Myb Transcriptionally Regulates the Mir-155 Host Gene in Chronic Lymphocytic Leukemia." Blood 117, no. 14 (2011): 3816-25.

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Internal error

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[XfIkgBJZX5gmPV5pBw@CYQAAAAI] 2019-12-12 11:29:06: Fatal exception of type "TypeError"

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