GPR1-AS is a novel imprinted gene that is expressed from a paternal allele in the human placenta
GPR1-AS:GPR1 antisense RNA (HGNC nomenclature)
"G protein-coupled receptor 1 antisense RNA", GPR1AS
Epigenetic regulation mechanisms in the imprinted GPR1-GPR1AS-ZDBF2 region were well-conserved betweenhuman and mouse genomes without the high sequence conservation of the intergenic lncRNAs. LncRNAs with highly conserved epigenetic and transcriptional regulation across species arose by divergent evolution from a common ancestor, if they do not have identical exon structures.
GPR1AS/Zdbf2linc is exclusively expressed in human/mouse placenta with paternal-allele-specific expression and maternal-allele-specific promoter methylation (GPR1/Gpr1 DMR).
GPR1AS/Zdbf2linc is rarely expressed throughout post-gastrulation development and into somatic tissues due to bi-allelic hypermethylation at their transcription start sites.
Labs working on this lncRNA
Department of BioScience; Tokyo University of Agriculture; Tokyo, Japan.
- Kobayashi H, Yanagisawa E, Sakashita A, Sugawara N, Kumakura S, Ogawa H, et al. Epigenetic and transcriptional features of the novel human imprinted lncRNA GPR1AS suggest it is a functional ortholog to mouse Zdbf2linc[J]. Epigenetics : official journal of the DNA Methylation Society. 2013,8(6):635-45.
GPR1-AS,GPR1AS,"G protein-coupled receptor 1 antisense RNA"