Please input one-sentence summary here.
SNHG1: Small nucleolar RNA host gene 1.
Alias symbols : UHG, NCRNA00057, LINC00057, lncRNA16
Spliced transcript with a number of short exons (>40bp) and snoRNA containing introns (Tycowski (1996)).
Transcriptional start site has characteristics of 5' TOP gene family (Tycowski (1996)).
~1.1kb transcript in human (Tycowski (1996)).
Contains 8 (maybe 9) snoRNAs in human, 8 in mouse (Tycowski (1996)).
Knockdown of SNHG1 inhibited proliferation of PC9 cells in vitro and also inhibited tumor growth in xenograft mouse models. Overexpression of SNHG1 promoted the proliferation of A549 cells in vitro and also promoted tumor growth in xenograft mouse models. Specifically, SNHG1 promoted G2/M transition by regulating cyclin B1 transcription((Zhu 2017)).
Early-stage lung cancer((Zhu 2017))
Localised to the cytoplasm and associates with ribosomes ((Pelczar 1998)).
RNA unstable in both human and mouse cells ((Tycowski 1996), (Friedel 2009), (Clark 2012)), can be stabilised by inhibition of protein synthesis. This suggests SNHG1 may be sensitive to nonsense-mediated decay and could be therefore be "translated" but perhaps only to degrade it ((Tycowski 1996)).
Up-regulated during lineage restriction of neural stem cells into bipotent neuronal/oligodendrocyte progenitors in vitro ((Mercer 2010)).
SNHG1 is up-regulated in gastric cancer(Cao 2013)).
SNHG1 was highly expressed in the lung cancer tissues and plasma and was detected at different stages of the disease, including the early stage((Zhu 2017)).
|Experiment||Forward primer||Reverse primer|
|Quantitative real-time PCR||5'-GATGACAGTCTGCCTCTATCTTAC- 3'||5'-CTTTGAGCCAAGCAGGTTATTG- 3'((Zhu 2017))|
Please input misc information here.
Please input transcriptomic nomeclature information here.
Please input regulation information here.
Allelic Information and Variation
Please input allelic information and variation information here.
Please input evolution information here.
You can also add sub-section(s) at will.
Labs working on this lncRNA
Please input related labs here.