Lnc-EIF3M-1:1

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Annotated Information

Name

WT1-AS: WT1 (Wilms' tumor 1) antisense transcript.

LncBook ID: HSALNT0289284

Characteristics

0.4 - 3kb, spliced and present in multiple splicing isoforms (Dallosso (2007)), as well as a protein coding isoform (WIT1) transcribed from a downstream promoter (Eccles (1994),Campbell (1994)). Transcribed antisense to WT1 from intron 1 or from the same promoter region (bidirectional) of WT1, corresponding to a differentially methylated regulatory region (Eccles (1994),Malik (1995),Malik (2000)).

Function

WT1-AS transcripts are exported to the cytoplasm and form heteroduplexes with WT1 mRNA, with a proposed regulatory role in WT1 expression via RNA:RNA interactions (Dallosso (2007)).

Disease

gastric cancer, hepatocellular carcinoma

Expression

Imprinted in humans (but not in mouse), with monoallelic (paternal) expression in normal kidney (Malik (2000),Dallosso (2004),Dallosso (2007)). Co-regulation with WT1 during mouse kidney development, and co-expression in mouse and human tissues, including fetal spleen, fetal kidney, and normal kidney (Dallosso (2007)). Abnormal splicing of WT1-AS has been reported in acute myeloid leukaemia (AML) samples (Dallosso (2007)).

Conservation

WT1 has a positionally conserved antisense/bidirectional transcripts in mouse and humans, although WT1-AS RNAs do not show extensive sequence conservation between these species, except at their 5' ends, which may extend into WT1 exon 1 (Dallosso (2007)).

Misc

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Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

Annotation originally sourced from lncRNAdb.

Basic Information

Transcript ID

lnc-EIF3M-1:1

Source

LNCipedia2.1

Same with

,

Classification

intergenic

Length

2354 nt

Genomic location

chr11+:32457284..32461620

Exon number

,

Exons

,

Genome context

Sequence
000001 AACCCAACAC GCGCTCTCAG CTGGCCGGTG TGGCACAACC CTCCCCCCAC CTCCCCTTCT TGGCCTTCGC CAGTGTGGGA 000080
000081 GCCTCGTCTC ACTGGAGAGT CCGTTCAGAA TCCTTGTGGG GGCGGGGAGG GGAAGAGCAC CGGTGCGAAC CCCGGGGTGC 000160
000161 CCCCTCGCCC GACTTGGACT TCTCCGACTA AAGAGGTGGG AGGAGTTCCC TGCAGCCTGC GGGGCCAAGA AGAAAGTGCT 000240
000241 AAGCTGAGGA GCCGCAGTCG GAGGACCCCA GGGACCCGAC AGGAAGTCTC CGTACGACCC CAACGGATCC ACATGCCCGG 000320
000321 AAGCCCAGGC GACACTAAGC CAGCGCTGGG GAACTGACGT ACTCCTGCAG TCGCAGGGCG CTCCATGCCT CTCTGTCCTC 000400
000401 TTCTTTGTTG TGGGTAACGT TCTCTGCGGG AGACCTGAGG TTTTCCAAGG GGGACATGCC AGCTACACTG GCCTTGGCGC 000480
000481 CCTGAGCTAA GCACCAGGAC TCACAGCCTA GCACGAAGGC AGGTAGCACC TTCACCCGCC GCGGACGATA GGCGCTCTCC 000560
000561 TGTACCTCCT TTAGCTCGCG AGGCCCGCCC TTCGCGAGGT CCCAGAGAAA AGCAGGCTGT GGAAAACTGG GCGCCCCCTT 000640
000641 CTTTCACCCA CCTTCTTACC CCTGTCAGCG CCGAGATCTG TAGCAGAGGT TCCTGGTCTG AACCACCGAT TGGCAAAGAA 000720
000721 AGCTGCAGAT TAAACTTCTC GTTTTACAGA GAAGGAAACT GAGGCCCAGA CAGCCGAAGG AGAGGCAGTC TATGGAGCGC 000800
000801 AGCGGTAAAG AGCAAGGGGT TGGTGGCCCC AGAATGGAAC CTCAGCTCTG CCAGGTAACC AACAGCTGTG TGACCCTAGA 000880
000881 CGAGTTCCGC AGTCTCTCTG AGCCTCAGTT TCCTTACTGG TCAAACGGGA TAATGGGATA CTAGCGCCCA CCTCATAGAG 000960
000961 TTGTTCTGAG GATTAGATAG GAGAGCAGTG TGGGCCTTTG ACTCAATCAA CTTTACAGTT TTTGTTACTA CTACTGTTTA 001040
001041 AGGACAGGAA ACAAGTTAGT GGCAACGCCG AGCTGAAACC CGGGTCTCTC AACGTCCAGT TGGAGGTTTT ACCCACCACC 001120
001121 CCTCTACCTC TTCAGAGCTA ATGGGATGCA GAGGCGAGGA CAGCCCCTGG AAAACCATGT GGCGTTGATA CACTGGCAAA 001200
001201 GCGCAGGCAT CCCGGCCTCG AAGGTGCATA ATTATTGCAA TATGAAAAAA TCGAGGCTGG GTAGGAGCAG GGCAGTGAGG 001280
001281 ATTTCTCAAC CCTTACTTTC ACCCCGGCGC TGTCCACTGC ATCTGACAGA GCGCGGAGCT GGGCTGCTAC AGCCGCAACC 001360
001361 CCAGGGACCA GTGCGCACGC CTGGGCCGCC CTCCGGGAGT CACCCAGCGG CCGCGGACAA CTGAATAAAC ACCCCAAAGC 001440
001441 GCTGCGGTCG GTCAAGGGCG GGGACAGCCA CACTGCGCGC GGGGCCCGCA GGCCGTAATA AAGAGTGGCT CGACCTCGCT 001520
001521 GCTGCCTGTC GCGGGAGAGG AACAAGCTTT CGACTAGCGC CTCTCCCCGG GGCCCGCGCC CCGAGCCCCA CGCGCAAGAC 001600
001601 AGCCCAACAG CTGTTCCTCC CCTCCCCGCC GACTCCAACT CTTCGGAATC TGCCCACTCG GGGCTGCAGG GCAAGTGTTT 001680
001681 AGGATGGTTC CCAGCCCCGC GCTGGCGGTG AAAATTTCAA CGTCATTCCT TCAATTAAAA AAAGGGGGGG GCAAGGGAGG 001760
001761 GGCTTTGTGA TAACTACTCC CAGCTTCTTC TGATCATTTC AAAATTAAGT CGATTTTTTT TAACCAGTCC CCACTTACTG 001840
001841 TCCTAACTCT CCTCGCTGAC CCTATCTGGG AGCCCGGAAC CGTTAGGTAC TGCCGAATGC GGTGCAAAAT TTCCCCCTCT 001920
001921 CCCCCAGTTC GCAGTGCCTG GAGCCGCTGG GGTTACTCGT CTGTTCTGAT GCCACCGCGA GATGGTCCCC GAGCTCCCCG 002000
002001 AGAGTCCTCA GTGAAAGGAT TCCGCGGCAC TGCCTCTATT ATTATACCGT AAATCTTTTT AAATTCTGGA ACTAATTATA 002080
002081 TAGAGGATAT GTCTCAATTT GTTCTGCATT AATGCCACAG TGGGGATGGA GGCCAGGCCG TGGCCAGAGC AGATACGTAG 002160
002161 GCCCATGAAA TTGATGAACT GAGAGTTGCT TCCAGTCCTG AGCGCACCAT CTGGAATTCC AGTCTGAGGT TACAATTAGA 002240
002241 ACTCCTGACC CCAGATTCAA CTTTGCAAAC AACAGGGGAA AAAAATGGGG AAAAGAAAAA CCACGAGAGA GGGAAAAAAA 002320
002321 ATTATTCTGC ACCTGTAAAA AAAAAAAAAA AAAA
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