KRT7-AS (KRT7 antisense RNA 1)
KRT7-AS is localized to the nucleus and it shares a 213-nucleotide-long region with the seventh exon of KRT7.
KRT7-AS levels are much lower than KRT7 mRNA levels in the same samples. In MKN28 and KATOIII cells, KRT7-AS is 61 and 41 fold lower than KRT7 mRNA (P<0.01).
KRT7-AS and KRT7 mRNA form a duplex RNA-RNA structure at their overlapping region, which can increase KRT7 mRNA stability and protect KRT7 mRNA from degradation. The overexpressed KRT7-AS in gastric cancer cells leads to increased proliferation and migration.
gastric cancer 
Labs working on this lncRNA
- Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
- Division of Gastroenterology, Departments of Medicine and Oncology and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
- Huang, B., et al., Long non-coding antisense RNA KRT7-AS is activated in gastric cancers and supports cancer cell progression by increasing KRT7 expression. Oncogene, 2016. 35(37): p. 4927-36.