JADRR is a key functional link that connects the DDR to histone H4 acetylation and play a potential role in breast tumorigenesis.
JADRR: JADE1 adjacent regulatory RNA (HGNC nomenclature)
JADRR,an independent transcript which contains no overlapping sequence with the transcripts from its neighbouring genes, is transcribed in the opposite orientation to the Jade1 gene in mouse, while its human homologue has the same orientation as Jade1 .
JADRR and Jade1 genes have distinct promoters at the chromosomal region 3qB in mouse .
JADRR is a key functional link that connects the DNA damage response (DDR) to histone H4 acetylation, and that dysregulation of JADRR may contribute to breast tumorigenesis . JADRR transcriptionally activates Jade1, a key component in the HBO1 (human acetylase binding to ORC1) histone acetylation complex. Consequently, JADRR induces histone H4 acetylation in the DDR .
The transactivation of JADRR is regulated by the ATM-NF-κB signalling in the DDR 
- Breast cancer
JADRR shows very low or undetectable expression levels in all of normal breast tissues. However, breast tumours exhibits overexpressed JADRR, and some tumour samples even show high or very high levels of JADRR .
The RT–PCR primers are shown below:
|Primer||Forward primer||Reverse primer|
>gi|478437780|gb|KC469579.1| Homo sapiens lncRNA-JADE, complete sequence
Labs working on this lncRNA
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. .
- Wan G, Hu X, Liu Y, Han C, Sood AK, Calin GA, et al. A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation[J]. The EMBO journal. 2013,32(21):2833-47.