hepatocellular carcinoma associated transcript 5 (non-protein coding)
FJ222407, "hepatoma associated gene", HTA
- Hepatocellular carcinoma
HCCAT5 gene encodes a protein of 92 amino acids with an estimated molecular weight of 10.2 kDa.
HCCAT5 could play important roles in Hepatocellular carcinoma(HCC) development and progression and can be a promising molecular target for the development of new diagnostic and therapeutic strategies for HCC.
Overexpression of the HCCAT5 gene in the hepatic cell line QSG-7701 via stable transfection can promote its proliferation rate and colony forming ability and change the cell cycle distribution of the cell lines.
The primer designed for HCCAT5 is described as the following: HCCAT5 of 607 bp, 5-GGCTTACACATGCTCTTGCT-3, (sense) and 5-GCCGAGTTCACTCATCCTTCT-3 (antisense); HCCAT5 is highly expressed in hepatocellular carcinoma line HepG2, but is not detected in other cell lines.
>gi|238859661|ref|NR_027756.1| Homo sapiens hepatocellular carcinoma associated transcript 5 (non-protein coding) (HCCAT5), long non-coding RNA
Labs working on this lncRNA
- Tumor Immunobiology Laboratory of Cancer Research Institute,Central South University, 410078 Changsha, Hunan, China .
- Tumor Immunobiology Laboratory of Cancer Research Institute,Central South University, 110 Xiangya Road, Changsha, Hunan 410078.
- Liu, Y., Y. Zhao, Q. Ju, L. Chen, F. Li, G. Zhou, P. Xie, G. Li, and Y. Li. "Molecular Clone and Functional Study of a Novel Hepatoma Associated Gene." Int J Oncol 42, no. 3 (2013): 1105-12.
- Yan L,Y. L, Fj.G, Miao Dai, Jj.Wang, Jinyue.Hu and Guancheng Li.(2010) Identification of HTA as a novel-specific marker for human hepatocellular carcinoma.J Cancer Res Clin Oncol,136:1187–1192.