Approved symbol：FOXP4-AS1:FOXP4 antisense RNA 1
LncBook transcript ID: HSALNT0106140
The FOXP4-AS1 gene is located at the chromosomal locus 6p21.1 and encodes a 588 bp transcript.
- FOXP4-AS1 overexpression is positively correlated with advanced pathological stages and larger tumour sizes in patients with CRC(colorectal cancer). FOXP4-AS1 knockdown can significantly inhibit cell viability all in five CRC cell lines, increase the percentage of cells in G0/G1 phase and decrease the percentage of cells in S and G2/M phase compared to control cells compared with control cells. as a result, FOXP4-AS1 promotes CRC cell proliferation by promoting cell cycle progression. In addition, FOXP4-AS1 knockdown can also induce CRC cell apoptosis and inhibits CRC cell tumourigenesis in vivo.
- Upregulated FOXP4-AS1 promotes the proliferation, migration and cell cycle, but inhibits apoptosis of Osteosarcoma (OS) cells. Furthermore, FOXP4-AS1 participates in the development and progression of OS by downregulating LATS1 via binding to LSD1 and EZH2.
The expression of FOXP4-AS1 is consistently up-regulated in CRC(colorectal cancer) than in adjacent normal tissues. In addition, BioGPS data set analysis indicates that the FOXP4-AS1 gene is not expressed in normal human colorectal tissues
FOXP4-AS1 was overexpressed in OS tissues than that of paracancerous tissues.
Colorectal cancer 
>NR_126415.1 Homo sapiens FOXP4 antisense RNA 1 (FOXP4-AS1), transcript variant 1, long non-coding RNA
Labs working on this lncRNA
- The Second Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, China.
- Department of Orthopedic Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
- Li J, Lian Y, Yan C, Cai Z, Ding J, Ma Z, Peng P, Wang K. Long non-coding RNA FOXP4-AS1 is an unfavourable prognostic factor and regulates proliferation and apoptosis in colorectal cancer. Cell Prolif. 2017 Feb;50(1).
- Yang L, Ge D, Chen X, Qiu J, Yin Z, Zheng S, Jiang C. Yang L1, Ge D2, Chen X1, Qiu J1, Yin Z1, Zheng S3, Jiang C4. Biochem Biophys Res Commun. 2018 Aug 25;502(4):493-500.