MIR222HG, which was located on Xp11.3 and interacts with miR-222 and miR-221, is up-regulated by Ang II and functions in promoting cell growth.
MIR222HG: MIR222 host gene(HGNC nomenclature)
MIR222HG, located on Xp11.3, is proximal to two miRNAs, miR-222 and miR-221, which have been previously associated with regulating VSMC proliferation and Ang II actions in endothelial cells.
Ang II-associated cardiovascular disease
Since miR-222 and miR-221 are known to play a role in proliferation of VSMCs (vascular smooth muscle cells), MIR222HG functioning in cell proliferation may likely be through its role as the host transcript for the two miRNAs.
MIR222HG may be conserved in human and mice as modification of H3K4me3 is not enriched at the locus encoding for miR-222/miR-221but is enriched ~25kb upstream from them.
MIR222HG was up-regulated by Ang II.
The pool of siRNA oligos for targeting MIR222HG are as follows,
Labs working on this lncRNA
- Department of Diabetes, City of Hope, Duarte, CA, 91010
- Leung A, Trac C, Jin W, Lanting L, Akbany A, Saetrom P, et al. Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells[J]. Circulation research. 2013,113(3):266-78.
NONHSAT136809, MIR222HG, Lnc-Ang362