MINCR, short for MYC-induced long noncoding RNA, is a novel player in MYC transcriptional network,with the potential to open new therapeutic windows in the fight against maglignant lymphoma and, possibly, all cancers that rely on MYC expression.
The MINCR gene, which is located on chromosome 8q24.3 and intergenic to the two coding genes GLI4 and ZNF696, has a long transform composed of three exons. It is ubiquitously expressed, with the highest expression values in brain, prostate, and testis .
MINCR could interplay with transcriptor MYC to co-regulate the expression level of a group of genes involved in cell cycle initiation and progression .
MINCR is found to be induced by MYC in not only restricted to B cell line but in MYC-regulated retinal pigment epithelial cell line hT-RPE-MycER .
MINCR strongly correlates with MYC expression in not only BL but more in general, GC-derived MYC-positive lymohomas and other cancer types, like pancreastic ductal adenocarcinomas, that are known to rely on MYC expression.
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MINCR is conserved throughout primates, with the exception of Galago, but not in other vertebrates .
Labs working on this lncRNA
- Fred Hutchinson Cancer Research Center 
- Doose G, Haake A, Bernhart SH, Lopez C, Duggimpudi S, Wojciech F, et al. MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cells[J]. Proceedings of the National Academy of Sciences of the United States of America. 2015,112(38):E5261-70.