PCAT7, 1322 bp long non-coding RNA, prostate cancer associated transcript 7.
PCAT7: prostate cancer associated transcript 7 (non-protein coding)(HGNC nomenclature)
PCAN-R2, "prostate cancer-associated noncoding RNA 2"
Prostate Cancer Associated Non-coding RNA 2, abbreviated as PCAN-R2 (Ensembl ID ENSG00000231806). PCAN-R2 showed positive correlation between gene expression and SCNA. PCAN-R2, the major isoform had an extra exon in the 5’end, and the remaining two exons also had different lengths from the Ensembl annotation. The new 5’ exon of PCAN-R2 was more consistent with the profile of H3K4me3, a histone mark of active promoter and the profile of DNase I hypersensitive regions in LNCaP cells.
Associated with cancer subtypes and clinical prognosis, and is a potential driver of cancer progression..
The new 5′exon of PCAN-R2 was more consistent with the profile of H3K4me3, a histone mark of active promoter and the profile of DNase I hypersensitive regions (i.e. the regions with an open chromatin state) in LNCaP cells .
PCAN-R2 showed a similar expression across different tissues.
Labs working on this lncRNA
- Department of Bioinformatics, School of Life Sciences and Technology, Tongji University, Shanghai, China.
- Du Z, Fei T, Verhaak RG, Su Z, Zhang Y, Brown M, et al. Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer[J]. Nature structural & molecular biology. 2013,20(7):908-13.