PTCSC2,shorted for papillary thyroid carcinoma susceptibility candidate 2, may functions in papillary thyroid cancer.
PTCSC2:papillary thyroid carcinoma susceptibility candidate 2 (non-protein coding)(HGNC nomenclature)
PTCSC2, a 1635 bp long intergenic noncoding RNA gene and locus in 9q22.33,named papillary thyroid cancer susceptibility candidate 2 (PTCSC2).
PTCSC2 plays an important role in the predisposition to PTC(papillary thyroid cancer).
PTCSC2 is involved in the regulation and interaction of coding and noncoding genes. The cells transfected with the PTCSC2-c construct showed a strong RT-PCR band in the presence of reverse transcriptase, but not in the absence of reverse transcriptase..
Forced expression of PTCSC2 in the BCPAP cell line affected the expression of a subset of noncoding and coding transcripts with enrichment of genes functionally involved in cell cycle and cancer .
Labs working on this lncRNA
- Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics.
- He H, Li W, Liyanarachchi S, Jendrzejewski J, Srinivas M, Davuluri RV, et al. Genetic predisposition to papillary thyroid carcinoma: involvement of FOXE1, TSHR, and a novel lincRNA gene, PTCSC2[J]. The Journal of clinical endocrinology and metabolism. 2015,100(1):E164-72.