GACAT3, gastric cancer associated transcript 3, plays crucial role during cancer progression and may be a potential tumor marker for gastric cancer.
GACAT3, gastric cancer associated transcript 3 (HGNC nomenclature)
As one of lncRNAs, GACAT3 was up-expressed in gastric cancer. Its levels were associated with tumor size, TNM stages, distal metastasis, and tissue CEA expression, which suggested that lncRNA-AC130710 plays crucial role during cancer progression and may be a potential tumor marker for gastric cancer.
miR-129-5p may play an important role in the down-regulating of GACAT3 expression in gastric cancer cells.
AC130710 was upregulated in the gastric cancer tissues and gastric cancer lines.
Labs working on this lncRNA
Department of Biochemistry and Molecular Biology, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo, 315211, China.
- Xu C, Shao Y, Xia T, Yang Y, Dai J, Luo L, et al. lncRNA-AC130710 targeting by miR-129-5p is upregulated in gastric cancer and associates with poor prognosis[J]. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2014,35(10):9701-6.