CASC11

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Annotated Information

Approved Symbol

CASC11: cancer susceptibility candidate 11 (non-protein coding)

Synonyms

A model of CASC11 involvement in CRC. [1].

TCONS_00014535, LINC00990, CARLo-7

Chromosome

8q24.21

RefSeq ID

NR_117102

Ensembl ID

ENSG00000249375

Function

CASC11 can promote colorectal cancer (CRC) cell proliferation and metastasis in vitro and in vivo.[1]

CASC11 can target heterogeneous ribonucleoprotein K (hnRNP-K) to activate WNT/β-catenin signaling in CRC cells. [1]

CASC11 participates in the development and progression of CRC by associating with hnRNP-K and activating WNT/β-catenin signaling. [1]

Expression

CASC11 is upregulated in CRC tissues; increased CASC11 expression in CRC was associated with tumor size, serosal invasion, lymph metastasis, and the tumor-node-metastasis (TNM) stage.[1]

Regulation

The c-Myc directly bound to the promoter regions of CASC11 and increased promoter histone acetylation to enhance CASC11 expression.[1]

Disease

CASC11 may serve as a candidate diagnostic biomarker and a promising therapeutic target for CRC. [1]

Sequence

>gi|620597373|ref|NR_117102.1| Homo sapiens cancer susceptibility candidate 11 (non-protein coding) (CASC11), transcript variant 2, long non-coding RNA

000001 TCTTTCAGGT TGGCTGCAGA AGGTCCGAAG AAAGAGGAGT TACTGGAGGA AAAAGTGGTT CAGAGGTGAC TATTCAACCG 000080
000081 CATAAGAGAT GGTGAAAATT AACCTATCAC CACTGCTAAT GAACATCACC CTATGGAGAA CCGGATCTCT CACTCTCACC 000160
000161 CAGGTTGGAG TGCAGTGGTG TGATCACGAC TCACTGCAGT CTTGAACTTG CCAGGCTCAA GCAATCCTCC TACCTCAGCC 000240
000241 TTCTGAGTAG CTGAGACCAC AGGGATGTGA AGAGACAGGG TCTCACTATA TTGCCCCGGC TAATCTCGAA CTCCTGGACT 000320
000321 CAAGCAATCT GCCCGCCTCA GCCTGCCAAA ATGCTGGGAT TACAGGAGAT CCCCAGAGGC AATTGTCCAC CTGACTTCAG 000400
000401 AATCAGAAGT AGCTCTGCTT TTCCTGAGAA GTGGTGCGGG TTTTGCCTTA TGGATGCTAA CTGAGACTGG AACATGTTCC 000480
000481 CTTTTTTGTA TCAGCTGCTG GTACAAAATT GAGAGTTGAG AGCCAAAACT GTACCCTTAT CACCTGTCAG TAACTTAAGG 000560
000561 AGGAAGTCAG CTACCATGCC TCCAGGACAC TCAAGTAACC CCATGGAGAT GACATTGCAG AGAAGAACTG GTCGAAAGCC 000640
000641 AGTACCCACT TTGCCATCTG TGTGAACAAT CCACCTTTGA GTGGGTCCTC CAGCCCACAT CAAGCCTTCA TATAACAGCA 000720
000721 GTCCTGAAGG ACATTTTATT GTAACCTCGT GAAAATCGAA GTAGGAACTC ACCAGCCAAG TTGCTCCTGA A

labs working on this lncRNA

  • Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China; Department of Pathology, Xinxiang Medical University, Xinxiang, Henan, China.

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Zhang Z, Zhou C, Chang Y, Zhang Z, Hu Y, Zhang F, et al. Long non-coding RNA CASC11 interacts with hnRNP-K and activates the WNT/beta-catenin pathway to promote growth and metastasis in colorectal cancer[J]. Cancer letters. 2016,376(1):62-73.