CASC11: cancer susceptibility candidate 11 (non-protein coding)
TCONS_00014535, LINC00990, CARLo-7
CASC11 can promote colorectal cancer (CRC) cell proliferation and metastasis in vitro and in vivo.
CASC11 can target heterogeneous ribonucleoprotein K (hnRNP-K) to activate WNT/β-catenin signaling in CRC cells. 
CASC11 participates in the development and progression of CRC by associating with hnRNP-K and activating WNT/β-catenin signaling. 
CASC11 is upregulated in CRC tissues; increased CASC11 expression in CRC was associated with tumor size, serosal invasion, lymph metastasis, and the tumor-node-metastasis (TNM) stage.
The c-Myc directly bound to the promoter regions of CASC11 and increased promoter histone acetylation to enhance CASC11 expression.
CASC11 may serve as a candidate diagnostic biomarker and a promising therapeutic target for CRC. 
>gi|620597373|ref|NR_117102.1| Homo sapiens cancer susceptibility candidate 11 (non-protein coding) (CASC11), transcript variant 2, long non-coding RNA
labs working on this lncRNA
- Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China; Department of Pathology, Xinxiang Medical University, Xinxiang, Henan, China.
- Zhang Z, Zhou C, Chang Y, Zhang Z, Hu Y, Zhang F, et al. Long non-coding RNA CASC11 interacts with hnRNP-K and activates the WNT/beta-catenin pathway to promote growth and metastasis in colorectal cancer[J]. Cancer letters. 2016,376(1):62-73.