ZEBTR, a lncRNA, promotes the proliferation and invasion of pancreatic cancer cells.
Approved symbol: ZEBTR
Approved name: ZEBTR : ZEB1 transcriptional regulator RNA
HGNC ID: HGNC: 53967
Alias symbols: LncRNA-BX111
Entrez Gene: 113391337
- ZEBTR promotes the proliferation and invasion of pancreatic cancer cells. Mechanically, BX111 activated transcription of ZEB1, a key regulator for epithelia-mesenchymal transition (EMT), via recruiting transcriptional factor Y-box protein (YB1) to its promoter region.
- In addition, ZEBTR contributes to the hypoxia-induced EMT of pancreatic cells by regulating expression of ZEB1 and its downstream proteins E-cadherin and MMP2.
ZEBTR transcription is induced by hypoxia-inducible factor (HIF-1α) in response to hypoxia.
Pancreatic cancer .
ZEBTR is overexpressed in human Pancreatic cancer.
Labs working on this lncRNA
- Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
- Shi-jiang Deng, Heng-yu Chen, Zeng Ye, Shi-chang Deng, Shuai Zhu, Zhu Zeng, Chi He, Ming-liang Liu, Kang Huang1, Jian-xin Zhong, Feng-yu Xu, Qiang Li1, Yang Liu1, Chun-you Wang and Gang Zhao. Hypoxia-induced LncRNA-BX111 promotes metastasis and progression of pancreatic cancer through regulating ZEB1 transcription. Oncogene. 2018 Nov;37(44):5811-5828.
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