WWOX-AS1:WWOX antisense RNA 1
LncRNA RP11-190D6.2 is the antisense transcript of protein-coding gene WWOX (WW domain-containing oxidoreductase) .
RP11-190D6.2 may play a pivotal role in the regulation of tumor metastasis . RP11-190D6.2 expression is positively correlated with WWOX expression (R=0.45519, P<0.00777), and WWOX is linked with poor prognosis in numerous cancers, including epithelial ovarian cancer (EOC) . RP11-190D6.2 overexpression inhibits proliferation, migration, and invasion abilities in HO8910-PM cells, whereas RP11-190D6.2 knockdown in HEY-A8 cells shows the opposite effect .
RP11-190D6.2 is restored by 5-aza-2′-deoxycytidine treatment in Epithelial ovarian cancer .
Epithelial ovarian cancer (EOC) 
Compared with the matched non-tumor tissues, the expression level of RP11-190D6.2 in tumor tissues is markedly decreased. Meanwhile, the expression of RP11-190D6.2 is remarkably downregulated in tumors with higher Federation of Gynecology and Obstetrics stage (III/IV) compared with tumors with lower FIGO stage(I/II) .
>XR_429776.2 PREDICTED: Homo sapiens uncharacterized LOC102724047 (LOC102724047), transcript variant X2, ncRNA
Labs working on this lncRNA
- Department of Oncology, The Fifth Hospital of Wuhan.
- Tong W, Yang L, Yu Q, Yao J, He A. A new tumor suppressor lncRNA RP11-190D6.2 inhibits the proliferation, migration, and invasion of epithelial ovarian cancer cells. Onco Targets Ther. 2017 Feb 27;10:1227-1235. doi: 10.2147/OTT.S125185. eCollection 2017.