Difference between revisions of "VPS9D1-AS1"
(Created page with "==Annotated Information== ===Approved Symbol=== VPS9D1-AS1 ===Approved Name=== VPS9D1 antisense RNA 1 ===Previous Symbols=== _ ===Synonyms=== MYU ===Chromosome=== 16q24.3 ===R...") |
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==Annotated Information== | ==Annotated Information== | ||
| − | === | + | ===Name=== |
| − | VPS9D1-AS1 | + | VPS9D1-AS1:VPS9D1 antisense RNA 1 |
| − | === | + | |
| − | VPS9D1 | + | MYU<ref name="ref1" /> |
| − | === | + | ===Characteristics=== |
| − | + | MYU is generated from the opposite strand of the VPS9D1 gene. <ref name="ref1" /> | |
| − | === | + | ===Cellular Localization=== |
| − | MYU | + | RT-PCR analysis reveals that the majority of the MYU transcripts were localized in the cytoplasm.<ref name="ref1" /> |
| − | === | + | ===Function=== |
| − | + | MYU associates with the RNA-binding protein heterogeneous nuclear ribonucleoprotein-K (hnRNP-K) to stabilize cyclin-dependent kinase 6 (CDK6) expression, thereby promoting the G1-S transition of the cell cycle.<ref name="ref1" /> | |
| − | === | + | |
| − | + | ===Expression=== | |
| − | === | + | MYU(LOC10012888) is upregulated in most colon cancers and required for the tumorigenicity of colon cancer cells. MYU |
| − | + | is also highly expressed in colorectal cancer cell lines compared with normal colon-derived fibroblast cells <ref name="ref1" /> | |
| − | == | + | ===Diseases=== |
| − | + | Colon cancer<ref name="ref1" /> | |
| − | == | + | ===Sequence=== |
| − | + | >NR_036480.1 Homo sapiens VPS9D1 antisense RNA 1 (VPS9D1-AS1), long non-coding RNA | |
| + | <dnaseq>AAAGCCTGGGCCCGTGGGGGACGCACATGGTCCTGTTCGTACTCCAGGATGGCGGCGTAAAGGGCCCGCT | ||
| + | GCTCCCGTTCCTCCGGGGTCAGGGCGACTTGGCTGCAAAACCTCCTGGGGAGAAAGGCACGCGGTGGGTG | ||
| + | CCGGGGCCAGGCCCTCCCCGCAGCGGCCCCAGGGGCGGGCAGGAGTCCCACCTGTTGGCGGCCTCCTGGA | ||
| + | GCCGCAGCCGGCGCTCCTCCATCTTTCTCTGGAGCTGGGTGCAGAGTCAAGGGGCCGAGCGTGGGATCTG | ||
| + | AGCGGGCCCTCGGTTCCCAACCCCGTCCCACACCCGGAGAGGCCGGGACGTCCCAGGGACCTCCTCTCGG | ||
| + | TGAGGGGCTGTCCCCAGGGAGGCCTCCTCCAGTGGCGTCAGCTCTCTGGAAATGTGACAAGCTGCTGTCT | ||
| + | AGACCCCAGGAAGCCCAGTGGTGTCTGGACACCAGAGGAGTCTCTCTCATCCTCCCGGATTGCTCTGAGG | ||
| + | CCAGGAGCTTTGTGACTCTGCCCCCTGAAGCTTCTGGAAGATCTCGGGTGGCAGAAAAGGAGAGAGCTTT | ||
| + | CCTCCTTCATCGGAGTATACACGGCGGTGTCGGCCGGCAGGCTGGGGAATGGGAGCAGCTGCAGGCATGG | ||
| + | TTGGCTTCAGGCGTGTTTTCCCTGCAAGCCATGGGTAACCAGGGGTCAAGCGGTGGGCCACATCCCACAG | ||
| + | AGGAGATGCGGGCTTGGGGGATGCCCCAGGAGAGCCGCCTACTGCAGGAGACCCACCAAGCTTGGCGGCC | ||
| + | GTCGACTGGGCCCTCTCCAGACACTGCTGTGCTAGCTTCAGCATCTTGGAGGTGTCGGGGGGCACAGTTT | ||
| + | CCCCAGCTTCTGGGGGAGGGACAAGAAGGCTGGTCACAGTCGGCTCTACCACTGTTACTTACTGCTGAGA | ||
| + | TAAAATGAGGCAACGGAAAAGGCCTCTGGGAAGTGGCCGTTTTACAGAGACAAGGACGTGCTGAGGGGAT | ||
| + | CGCCTCACCCATCTCCCACCGGCTGTGTCCCCAAAGTCCTGCCTTCCCGTAGCTTGGCATGGAGCACCTC | ||
| + | TGCGCGACCATGGACCTGCTCACACAGCCCTTCTGCGCGCCGTGGGAGCTGCCTCTCTGTGACTCGCCCC | ||
| + | TGGACCCACCGCCCCAGCGCCTGACCCACCTCCCTGCTGCCCTTCACAGAAAACTTCTCATAGACTCCCA | ||
| + | TTTTCTCATCCCGCCCCGATTTAGCCCCCGACTCCCCCCGGAAACTGCCCTTACCCGTCCCCACCTTGCC | ||
| + | AGACACGGTGGGCCACTGGAGTTCCTCTGTCTTCTGGGACTTTGCTCTCCCCAGGGGATCCTCTGCCACT | ||
| + | CCTCCACCCAACTCCTCAATCTTGGAGCGCCAGAGCTCAGCCGAGCTCACCGGCTCCCTAGGGAGCTGGG | ||
| + | GCAACTGTTAGCTCCCCCTGACCTGTGTGATCCTACGTCCAGTGGCTGCCCCGACCTCTGTGATCCCACG | ||
| + | TCCAGGGGCTCCCCCGACCTCTGTGATCCCACGTCCAGTGGCTCCCCCGACCTCTGTGCTCCCACGTCCA | ||
| + | GTGGCTCCCCCGACCTCTGTGCTCCCACGTCCAGTGGCTCCCCCGACCTCTGTGCTCCCACGTCCAGTGG | ||
| + | GTCCCCCTGACCTCTGTGATCCCACGTCCAGTGGCTCCCCCTGACCTCTGTGCTCTATGTCCAGTGGCTC | ||
| + | CCCCTGACCTCTGTGATCCTTTGTGCAGCGGCTGCTGGCCTCTCAAACTTAATGTGTTCATTGCGGAACT | ||
| + | TGC | ||
| + | </dnaseq> | ||
| + | |||
| + | ==Labs working on this lncRNA== | ||
| + | *Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. Electronic address: kawasaki@iam.u-tokyo.ac.jp. | ||
| + | ==References== | ||
| + | <references> | ||
| + | <ref name="ref1"> | ||
| + | Kawasaki Y, Komiya M, Matsumura K, Negishi L, Suda S, Okuno M, Yokota N, Osada | ||
| + | T, Nagashima T, Hiyoshi M, Okada-Hatakeyama M, Kitayama J, Shirahige K, Akiyama | ||
| + | T. MYU, a Target lncRNA for Wnt/c-Myc Signaling, Mediates Induction of CDK6 to | ||
| + | Promote Cell Cycle Progression. Cell Rep. 2016 Sep 6;16(10):2554-2564. | ||
| + | </ref> | ||
| + | </references> | ||
Revision as of 09:00, 14 December 2017
Contents
Annotated Information
Name
VPS9D1-AS1:VPS9D1 antisense RNA 1
MYU[1]
Characteristics
MYU is generated from the opposite strand of the VPS9D1 gene. [1]
Cellular Localization
RT-PCR analysis reveals that the majority of the MYU transcripts were localized in the cytoplasm.[1]
Function
MYU associates with the RNA-binding protein heterogeneous nuclear ribonucleoprotein-K (hnRNP-K) to stabilize cyclin-dependent kinase 6 (CDK6) expression, thereby promoting the G1-S transition of the cell cycle.[1]
Expression
MYU(LOC10012888) is upregulated in most colon cancers and required for the tumorigenicity of colon cancer cells. MYU is also highly expressed in colorectal cancer cell lines compared with normal colon-derived fibroblast cells [1]
Diseases
Colon cancer[1]
Sequence
>NR_036480.1 Homo sapiens VPS9D1 antisense RNA 1 (VPS9D1-AS1), long non-coding RNA
000001 AAAGCCTGGG CCCGTGGGGG ACGCACATGG TCCTGTTCGT ACTCCAGGAT GGCGGCGTAA AGGGCCCGCT GCTCCCGTTC 000080
000081 CTCCGGGGTC AGGGCGACTT GGCTGCAAAA CCTCCTGGGG AGAAAGGCAC GCGGTGGGTG CCGGGGCCAG GCCCTCCCCG 000160
000161 CAGCGGCCCC AGGGGCGGGC AGGAGTCCCA CCTGTTGGCG GCCTCCTGGA GCCGCAGCCG GCGCTCCTCC ATCTTTCTCT 000240
000241 GGAGCTGGGT GCAGAGTCAA GGGGCCGAGC GTGGGATCTG AGCGGGCCCT CGGTTCCCAA CCCCGTCCCA CACCCGGAGA 000320
000321 GGCCGGGACG TCCCAGGGAC CTCCTCTCGG TGAGGGGCTG TCCCCAGGGA GGCCTCCTCC AGTGGCGTCA GCTCTCTGGA 000400
000401 AATGTGACAA GCTGCTGTCT AGACCCCAGG AAGCCCAGTG GTGTCTGGAC ACCAGAGGAG TCTCTCTCAT CCTCCCGGAT 000480
000481 TGCTCTGAGG CCAGGAGCTT TGTGACTCTG CCCCCTGAAG CTTCTGGAAG ATCTCGGGTG GCAGAAAAGG AGAGAGCTTT 000560
000561 CCTCCTTCAT CGGAGTATAC ACGGCGGTGT CGGCCGGCAG GCTGGGGAAT GGGAGCAGCT GCAGGCATGG TTGGCTTCAG 000640
000641 GCGTGTTTTC CCTGCAAGCC ATGGGTAACC AGGGGTCAAG CGGTGGGCCA CATCCCACAG AGGAGATGCG GGCTTGGGGG 000720
000721 ATGCCCCAGG AGAGCCGCCT ACTGCAGGAG ACCCACCAAG CTTGGCGGCC GTCGACTGGG CCCTCTCCAG ACACTGCTGT 000800
000801 GCTAGCTTCA GCATCTTGGA GGTGTCGGGG GGCACAGTTT CCCCAGCTTC TGGGGGAGGG ACAAGAAGGC TGGTCACAGT 000880
000881 CGGCTCTACC ACTGTTACTT ACTGCTGAGA TAAAATGAGG CAACGGAAAA GGCCTCTGGG AAGTGGCCGT TTTACAGAGA 000960
000961 CAAGGACGTG CTGAGGGGAT CGCCTCACCC ATCTCCCACC GGCTGTGTCC CCAAAGTCCT GCCTTCCCGT AGCTTGGCAT 001040
001041 GGAGCACCTC TGCGCGACCA TGGACCTGCT CACACAGCCC TTCTGCGCGC CGTGGGAGCT GCCTCTCTGT GACTCGCCCC 001120
001121 TGGACCCACC GCCCCAGCGC CTGACCCACC TCCCTGCTGC CCTTCACAGA AAACTTCTCA TAGACTCCCA TTTTCTCATC 001200
001201 CCGCCCCGAT TTAGCCCCCG ACTCCCCCCG GAAACTGCCC TTACCCGTCC CCACCTTGCC AGACACGGTG GGCCACTGGA 001280
001281 GTTCCTCTGT CTTCTGGGAC TTTGCTCTCC CCAGGGGATC CTCTGCCACT CCTCCACCCA ACTCCTCAAT CTTGGAGCGC 001360
001361 CAGAGCTCAG CCGAGCTCAC CGGCTCCCTA GGGAGCTGGG GCAACTGTTA GCTCCCCCTG ACCTGTGTGA TCCTACGTCC 001440
001441 AGTGGCTGCC CCGACCTCTG TGATCCCACG TCCAGGGGCT CCCCCGACCT CTGTGATCCC ACGTCCAGTG GCTCCCCCGA 001520
001521 CCTCTGTGCT CCCACGTCCA GTGGCTCCCC CGACCTCTGT GCTCCCACGT CCAGTGGCTC CCCCGACCTC TGTGCTCCCA 001600
001601 CGTCCAGTGG GTCCCCCTGA CCTCTGTGAT CCCACGTCCA GTGGCTCCCC CTGACCTCTG TGCTCTATGT CCAGTGGCTC 001680
001681 CCCCTGACCT CTGTGATCCT TTGTGCAGCG GCTGCTGGCC TCTCAAACTT AATGTGTTCA TTGCGGAACT TGC
000081 CTCCGGGGTC AGGGCGACTT GGCTGCAAAA CCTCCTGGGG AGAAAGGCAC GCGGTGGGTG CCGGGGCCAG GCCCTCCCCG 000160
000161 CAGCGGCCCC AGGGGCGGGC AGGAGTCCCA CCTGTTGGCG GCCTCCTGGA GCCGCAGCCG GCGCTCCTCC ATCTTTCTCT 000240
000241 GGAGCTGGGT GCAGAGTCAA GGGGCCGAGC GTGGGATCTG AGCGGGCCCT CGGTTCCCAA CCCCGTCCCA CACCCGGAGA 000320
000321 GGCCGGGACG TCCCAGGGAC CTCCTCTCGG TGAGGGGCTG TCCCCAGGGA GGCCTCCTCC AGTGGCGTCA GCTCTCTGGA 000400
000401 AATGTGACAA GCTGCTGTCT AGACCCCAGG AAGCCCAGTG GTGTCTGGAC ACCAGAGGAG TCTCTCTCAT CCTCCCGGAT 000480
000481 TGCTCTGAGG CCAGGAGCTT TGTGACTCTG CCCCCTGAAG CTTCTGGAAG ATCTCGGGTG GCAGAAAAGG AGAGAGCTTT 000560
000561 CCTCCTTCAT CGGAGTATAC ACGGCGGTGT CGGCCGGCAG GCTGGGGAAT GGGAGCAGCT GCAGGCATGG TTGGCTTCAG 000640
000641 GCGTGTTTTC CCTGCAAGCC ATGGGTAACC AGGGGTCAAG CGGTGGGCCA CATCCCACAG AGGAGATGCG GGCTTGGGGG 000720
000721 ATGCCCCAGG AGAGCCGCCT ACTGCAGGAG ACCCACCAAG CTTGGCGGCC GTCGACTGGG CCCTCTCCAG ACACTGCTGT 000800
000801 GCTAGCTTCA GCATCTTGGA GGTGTCGGGG GGCACAGTTT CCCCAGCTTC TGGGGGAGGG ACAAGAAGGC TGGTCACAGT 000880
000881 CGGCTCTACC ACTGTTACTT ACTGCTGAGA TAAAATGAGG CAACGGAAAA GGCCTCTGGG AAGTGGCCGT TTTACAGAGA 000960
000961 CAAGGACGTG CTGAGGGGAT CGCCTCACCC ATCTCCCACC GGCTGTGTCC CCAAAGTCCT GCCTTCCCGT AGCTTGGCAT 001040
001041 GGAGCACCTC TGCGCGACCA TGGACCTGCT CACACAGCCC TTCTGCGCGC CGTGGGAGCT GCCTCTCTGT GACTCGCCCC 001120
001121 TGGACCCACC GCCCCAGCGC CTGACCCACC TCCCTGCTGC CCTTCACAGA AAACTTCTCA TAGACTCCCA TTTTCTCATC 001200
001201 CCGCCCCGAT TTAGCCCCCG ACTCCCCCCG GAAACTGCCC TTACCCGTCC CCACCTTGCC AGACACGGTG GGCCACTGGA 001280
001281 GTTCCTCTGT CTTCTGGGAC TTTGCTCTCC CCAGGGGATC CTCTGCCACT CCTCCACCCA ACTCCTCAAT CTTGGAGCGC 001360
001361 CAGAGCTCAG CCGAGCTCAC CGGCTCCCTA GGGAGCTGGG GCAACTGTTA GCTCCCCCTG ACCTGTGTGA TCCTACGTCC 001440
001441 AGTGGCTGCC CCGACCTCTG TGATCCCACG TCCAGGGGCT CCCCCGACCT CTGTGATCCC ACGTCCAGTG GCTCCCCCGA 001520
001521 CCTCTGTGCT CCCACGTCCA GTGGCTCCCC CGACCTCTGT GCTCCCACGT CCAGTGGCTC CCCCGACCTC TGTGCTCCCA 001600
001601 CGTCCAGTGG GTCCCCCTGA CCTCTGTGAT CCCACGTCCA GTGGCTCCCC CTGACCTCTG TGCTCTATGT CCAGTGGCTC 001680
001681 CCCCTGACCT CTGTGATCCT TTGTGCAGCG GCTGCTGGCC TCTCAAACTT AATGTGTTCA TTGCGGAACT TGC
Labs working on this lncRNA
- Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. Electronic address: kawasaki@iam.u-tokyo.ac.jp.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Kawasaki Y, Komiya M, Matsumura K, Negishi L, Suda S, Okuno M, Yokota N, Osada T, Nagashima T, Hiyoshi M, Okada-Hatakeyama M, Kitayama J, Shirahige K, Akiyama T. MYU, a Target lncRNA for Wnt/c-Myc Signaling, Mediates Induction of CDK6 to Promote Cell Cycle Progression. Cell Rep. 2016 Sep 6;16(10):2554-2564.
