Difference between revisions of "SMILR"
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Revision as of 10:08, 25 September 2017
Contents
Annotated Information
Approved Symbol
SMILR: smooth muscle induced lncRNA, enhancer of proliferation [1]
RP11-94a24.1 [1]
Chromosome
8q24.13
RefSeq(supplied by NCBI)
NR_131202
Characteristics
SMILR is located ~750 kbp downstream of HAS2 on the same (reverse) strand and ~350 kbp from ZHX2 and ~750 kbp from HAS2-AS1 on the opposite strand of chromosome 8 [1]. The longest open reading frame(ORF) within SMILR is 57 amino acids [1].
Cellular Localization
SMILR is located in both nucleus and cytoplasm [1].
Expression
SMILR is expressed highest in heart [1]. It is differentially expressed in human saphenous vein-derived smooth muscle cells following stimulation with interleukin-1α and platelet-derived growth factor [1]. Increased expression of SMILR is observed in unstable atherosclerotic plaques, and plasma from patients with high plasma C-reactive protein [1].
Function
SMILR acts as a driver of vascular smooth muscle cell proliferation [1]. Knockdown of SMILR markedly reduced cell proliferation and HAS2 expression was also reduced by SMILR knockdown [1].
Regulation
SMILR expression can be regulated by IL1α or PDGF and it is a time-dependent manner [1].
Disease
- Cardiovascular disease
Labs working on this lncRNA
- BHF Glasgow Cardiovascular Research Centre, University of Glasgow, United Kingdom
- British Heart Foundation/University of Edinburgh Centre for Cardiovascular Science, Edinburgh, United Kingdom
References
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Ballantyne, M.D., Pinel, K., Dakin, R., Vesey, A.T., Diver, L., Mackenzie, R., Garcia, R., Welsh, P., Sattar, N., Hamilton, G. et al. (2016) Smooth Muscle Enriched Long Noncoding RNA (SMILR) Regulates Cell Proliferation. Circulation, 133, 2050-2065.
