SKP2

Annotation

Name

SKP2

Alias

NA

Disease

Disease: non-small cell lung cancer (PMID:26482610)

Dysfunction type: interaction

Description: The Skp2 may be regulated by Meg3 at post-transcriptional level. Bioinformatics analyses showed that miR-3163 bound to 3'-UTR of Skp2 mRNA in NSCLC cells to inhibit its translation, which was supported by luciferase reporter assay. Meg3 augmented the effects of miR-3163 on Skp2 mRNA, possibly through binding-induced function enhancement, which was supported by the double fluorescent in situ hybridization showing co-localized intracellular Meg3 and miR-3163 signals in NSCLC cells. The miR-3163 levels in NSCLC were not different from in NT, suggesting that the regulation of Skp2 in NSCLC by miR-3163 may require coordination of Meg3

Function

Function Mechanism: NA (PMID:26482610)

Biological Process: pathogenic process

Description: NA