Difference between revisions of "SIRLNT"
(Created page with "''SIRLNT'', SIRT1 regulating lncRNA tumor promoter, a tumor promoter in breast cancer associated with breast cancer progression and chemoresistance by regulating the expressio...")
Latest revision as of 08:34, 19 December 2018
SIRLNT, SIRT1 regulating lncRNA tumor promoter, a tumor promoter in breast cancer associated with breast cancer progression and chemoresistance by regulating the expression of miR-4766-5p.
SIRLNT: SIRT1 regulating lncRNA tumor promoter (HGNC:53902)
lncRNA-PRLB: progression-associated lncRNA in breast cancer 
LncRNA-PRLB is located on 8p11.21 in humans and is composed of three exons and has a full length of 663 nt. The open reading frame finder of the National Center for Biotechnology Information and conserved domain database failed to predict a protein of more than 55 amino acids based on the lncRNA-PRLB sequence. . In addition, lncRNA-PRLB does not contain a valid Kozak consensus sequence, which further supported the notion that the lncRNA-PRLB has no protein-coding potential.
lncRNA-PRLB functions as a ceRNA or sponge for miR-4766-5p which is a tumor suppressor in breast cancer. lncRNA-PRLB could regulate the progression and chemoresistance of breast cancer via modulating the expression levels of miR-4766-5p and SIRT1, which may have a pivotal role in breast cancer treatment and prognosis prediction.
Importantly, miR-4766-5p overexpression caused opposite changes in the expression levels of lncRNA-PRLB, indicating that there exists mutual regulation between miR-4766-5p and lncRNA-PRLB.
Higher level of lncRNA-PRLB was identified in the primary tumor tissue from patients who developed metastasis. Furthermore, Kaplan–Meier survival analysis showed that patients with high lncRNA-PRLB expression levels exhibited poor overall survival and disease-free survival. high lncRNA-PRLB expressions in tumors and lymph node metastasis had significantly higher risk of death. 
Labs working on this lncRNA
- Department of Breast Surgery, Qilu Hospital, Shandong University, 250012 Jinan, Shandong China
- Pathology Tissue Bank, Qilu Hospital, Shandong University, 250012 Jinan, Shandong China
- Department of Urology, Shandong Cancer Hospital affiliated to Shandong University, 250117 Jinan, Shandong China
- Liang Y, Song X, Li Y, Sang Y, Zhang N, Zhang H et al. A novel long non-coding RNA-PRLB acts as a tumor promoter through regulating miR-4766-5p/SIRT1 axis in breast cancer[J]. Cell death & disease. 2018, 9(5):563-563.
>gi|112543493|ref|NR_156738.1| Homo sapiens SIRT1 regulating lncRNA tumor promoter (SIRLNT), long non-coding RNA