Difference between revisions of "SIRLNT"

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Latest revision as of 08:34, 19 December 2018

SIRLNT, SIRT1 regulating lncRNA tumor promoter, a tumor promoter in breast cancer associated with breast cancer progression and chemoresistance by regulating the expression of miR-4766-5p.

Annotated Information

Name

SIRLNT: SIRT1 regulating lncRNA tumor promoter (HGNC:53902)

Alias

lncRNA-PRLB: progression-associated lncRNA in breast cancer [1]

Characteristics

LncRNA-PRLB is located on 8p11.21 in humans and is composed of three exons and has a full length of 663 nt. The open reading frame finder of the National Center for Biotechnology Information and conserved domain database failed to predict a protein of more than 55 amino acids based on the lncRNA-PRLB sequence. . In addition, lncRNA-PRLB does not contain a valid Kozak consensus sequence, which further supported the notion that the lncRNA-PRLB has no protein-coding potential.[1]

Function

lncRNA-PRLB functions as a ceRNA or sponge for miR-4766-5p which is a tumor suppressor in breast cancer. lncRNA-PRLB could regulate the progression and chemoresistance of breast cancer via modulating the expression levels of miR-4766-5p and SIRT1, which may have a pivotal role in breast cancer treatment and prognosis prediction.[1]

Regulation

Importantly, miR-4766-5p overexpression caused opposite changes in the expression levels of lncRNA-PRLB, indicating that there exists mutual regulation between miR-4766-5p and lncRNA-PRLB.[1]

Expression

Higher level of lncRNA-PRLB was identified in the primary tumor tissue from patients who developed metastasis. Furthermore, Kaplan–Meier survival analysis showed that patients with high lncRNA-PRLB expression levels exhibited poor overall survival and disease-free survival. high lncRNA-PRLB expressions in tumors and lymph node metastasis had significantly higher risk of death. [1]

Disease

Breast Cancer[1]

Labs working on this lncRNA

  • Department of Breast Surgery, Qilu Hospital, Shandong University, 250012 Jinan, Shandong China
  • Pathology Tissue Bank, Qilu Hospital, Shandong University, 250012 Jinan, Shandong China
  • Department of Urology, Shandong Cancer Hospital affiliated to Shandong University, 250117 Jinan, Shandong China

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Liang Y, Song X, Li Y, Sang Y, Zhang N, Zhang H et al. A novel long non-coding RNA-PRLB acts as a tumor promoter through regulating miR-4766-5p/SIRT1 axis in breast cancer[J]. Cell death & disease. 2018, 9(5):563-563.

Sequence

>gi|112543493|ref|NR_156738.1| Homo sapiens SIRT1 regulating lncRNA tumor promoter (SIRLNT), long non-coding RNA

000001 GTGGTGACTG AAACCACACG CCATGTTGGG AGACTTCCAA ACAAGTCTAG AGAGTTGGCA CTTAGGGATG AAGAAATCAT 000080
000081 CTTCTGGGTA CACTTGGTCT TTCCTGATGA CGCTTTTAAG AGAAAGGCAG AGTTGACCCT GGGCTTTCAA AAAACTGTTC 000160
000161 TTTCAGGCAA AACCTCAGAG AGAACTGGCT GCTAGTGATC CTCTGCAGAG ACCTTGAAGA GCACGGCAAT TATGAAACTT 000240
000241 CAACAAGAAA AGATTTAAGC TGATCTTTTA AAAAAATATA TACTGTCAGG AATTTTGTAG AAATGACTTT AATGTAATAA 000320
000321 CTGCTTCTTT GACTTATGTT TTGTCTTGTG GTGAAAAGAA AAATATTTAT AAAAGCATGC CTGTGTCCTA AAATTGGGGA 000400
000401 CACAAACTTA AATGACTGAA GGCACTTGAG GAGTGGAGGC AAGGATGGTG AAACCAGGCC CTGTACCAAG CAGGAGAGCG 000480
000481 TGAACCTGCT AAAGAGAGTG ACTGCTTCTC ATTTCCAGTC AATGCGACTG GTGTCGCATT CCAGTCAAAT GGAGTTGCGA 000560
000561 CACCATTTCA GCCACAGCGA TTGATCTGGA TTTTCTGTAA AATTCCCTGA TTTTTACATA TTGCCAATTA ATTAATTAAT 000640
000641 TAAAAAGAAA TGTAGATGTT CAA