Difference between revisions of "PTENP1-AS"

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===Function===
 
===Function===
[[File:PTENP1-AS.jpg|right|thumb|400px|'''''PTENP1-AS'' based regulation of tumor suppressor gene PTEN.''' Three different isoforms of the PTENP1-AS (PTENpg1 asRNA) are transcribed: PTENpg1 asRNA α, β and the unspliced nuclear localized PTENpg1 asRNA α (1–2). ''PTEN'' transcription is suppressed by the PTENpg1 asRNA α and unspliced isoforms, which act in trans by recruiting the chromatin-repressor proteins EZH2 and DNMT3A to the PTEN promoter (3). The PTENpg1 sense lacks a poly(A) tail, and the stability and export of PTENpg1 sense to the cytoplasm is facilitated by the interaction with the spliced PTENpg1 asRNA β transcripts (4). Such interactions lead to an increase of PTENpg1 sense sponge activity and thus increased PTEN mRNA stability and translation (5). This mechanism (1–5) results in both transcriptional and post-transcriptional regulation of PTEN by its pseudogene. The model indicates a level of synchronization between the pseudogene and its protein-coding counterpart.<ref name="ref1" />]]
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[[File:PTENP1-AS.jpg|right|thumb|300px|'''''PTENP1-AS'' based regulation of tumor suppressor gene PTEN.''' Three different isoforms of the PTENP1-AS (PTENpg1 asRNA) are transcribed: PTENpg1 asRNA α, β and the unspliced nuclear localized PTENpg1 asRNA α (1–2). ''PTEN'' transcription is suppressed by the PTENpg1 asRNA α and unspliced isoforms, which act in trans by recruiting the chromatin-repressor proteins EZH2 and DNMT3A to the PTEN promoter(3). The PTENpg1 sense lacks a poly(A) tail, and the stability and export of PTENpg1 sense to the cytoplasm is facilitated by the interaction with the spliced PTENpg1 asRNA β transcripts (4). Such interactions lead to an increase of PTENpg1 sense sponge activity and thus increased PTEN mRNA stability and translation (5). This mechanism (1–5) results in both transcriptional and post-transcriptional regulation of PTEN by its pseudogene. The model indicates a level of synchronization between the pseudogene and its protein-coding counterpart.<ref name="ref1" />]]
  
 
''PTENP1-AS'' regulates ''PTEN'' transcription and PTEN mRNA stability <ref name="ref1" />.
 
''PTENP1-AS'' regulates ''PTEN'' transcription and PTEN mRNA stability <ref name="ref1" />.

Latest revision as of 07:08, 17 November 2018

Annotated Information

Name

PTENP1-AS: PTENP1 antisense RNA (HGNC nomenclature)

Characteristics

PTENP1-AS is a four-exontranscript of 888 bp (GenBank) that is found on human chromosome 9p13.3.

Function

PTENP1-AS based regulation of tumor suppressor gene PTEN. Three different isoforms of the PTENP1-AS (PTENpg1 asRNA) are transcribed: PTENpg1 asRNA α, β and the unspliced nuclear localized PTENpg1 asRNA α (1–2). PTEN transcription is suppressed by the PTENpg1 asRNA α and unspliced isoforms, which act in trans by recruiting the chromatin-repressor proteins EZH2 and DNMT3A to the PTEN promoter(3). The PTENpg1 sense lacks a poly(A) tail, and the stability and export of PTENpg1 sense to the cytoplasm is facilitated by the interaction with the spliced PTENpg1 asRNA β transcripts (4). Such interactions lead to an increase of PTENpg1 sense sponge activity and thus increased PTEN mRNA stability and translation (5). This mechanism (1–5) results in both transcriptional and post-transcriptional regulation of PTEN by its pseudogene. The model indicates a level of synchronization between the pseudogene and its protein-coding counterpart.[1]

PTENP1-AS regulates PTEN transcription and PTEN mRNA stability [1].

PTENP1-AS regulates the cell cycle and apoptosis [1].

Expression

Regulation

Diseases

Labs working on this lncRNA

  • Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.[1]
  • Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California, USA.[1]
  • School of Biotechnology and Biomedical Sciences, University of New South Wales, Sydney, Australia.[1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Johnsson P, Ackley A, Vidarsdottir L, Lui WO, Corcoran M, Grander D et al. A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells[J]. Nat Struct Mol Biol. 2013, 20(4):440-446.

Sequence

>gi|762006042|ref|NR_103745.2| Homo sapiens PTENP1 antisense RNA (PTENP1-AS), long non-coding RNA

000001 GGAAGAGGCT GCACAGTTAG AAAAGACGAA GAAGAAGCGA GAAACGCCGC CGCTGCCGGC GCCGCCCCCG CGGATGCTCA 000080
000081 CGGGTTGCTG AGAGGGGCTT CAGGCCGGGC CGGGCCGGGC CGCCGCCGCC GCCGCCGTCT CTGTCTCTCA TCTCCCTCGC 000160
000161 CTGAGCCCGG CCTCGCCTCA CAGCGGCTCA ACATTCAAAC TTCCATCACG GCTGCAGCTT CTGAGAGGAG AGCATCTTCT 000240
000241 AGGATCATGT AGTCGGAGAT TAAAAAGAGT TCTACTTTTT CCTTTCCAAC CTGGAAGCCT TTTATTGCAA TTTCTTATCT 000320
000321 GACTGTACTG TCTGATATCT CCAGTGCAAG GTTGAATAAA AGTAGTGAAA ACAGACATTG TTACTTTGCT ACCAAAATTA 000400
000401 TAGGCAAAGC ATTCAGTCTT TTGAAGCTTT CATGTTTAAG TTCTTCAGTT TTTGGACTCT TGGACTTAAA CCAGTGATTT 000480
000481 GCCAGGGGCT CTTGGACCTT CGGCCACAGA CTGAAGGCTG CACTGTCAAC TTCCCTACTT TTGATGTTTT GGGACTCAGA 000560
000561 CTGGCTTCCT GGCTCCTCAG CTTGCAGAAG ACCTATTGTG GGACTTTACC TTGTGTTTGT GGGTCCCATG AAGGAGCAGG 000640
000641 AAACTCAATT GTGGAAGCAC ACGTTTTTCC CTTTATTAAT GTTCATGACT CCTCCTATAC CTTATTGTAT ATCTATATTT 000720
000721 GGCCATTCCA CTCAGCATGT ATTTCTTTTC CCTTTGCCCC TCCCTAGACA TGTCTGTTTC TGGCTTCTTG CCAGAGCTGT 000800
000801 GCTTCCCAGC CTGTCAGAAT GGCCACACTG CAGGCTGCAA CCCTTTATGA GAAATAAAGC TCTCCCTTCC AAAAAAAAAA 000880
000881 AAAAAAAA