Difference between revisions of "PSMD6-AS1"
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===Diseases=== | ===Diseases=== | ||
| − | Gliomas<ref name="ref1" /> | + | * Gliomas<ref name="ref1" /> |
| − | Papillary Thyroid Cancer<ref name="ref2" /> | + | * Papillary Thyroid Cancer<ref name="ref2" /> |
==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
Revision as of 08:41, 26 July 2017
Contents
Annotated Information
Name
PSMD6-AS1:PSMD6 antisense RNA 1
Lnc00462717[1]
ENST00000462717[2]
Characteristics
Lnc00462717 is located on chromosome 12 upstream of the MDM2 promoter region[1].
Function
lnc00462717 may function in suppressing glioma cell proliferation, survival, migration and may potentially serve as a novel biomarker and therapeutic target for glioma [1]. lnc00462717 inversely regulates MDM2 expression and plays important roles by partially regulating the MDM2/MAPK pathway in glioma [1].
ENST00000462717 is found to be upregulated in the non-131I-avid lung metastases of Papillary Thyroid Cancer (PTC), and low expression level of ENST00000462717 is associated with better prognosis of PTC patients with lung metastases [2].
Regulation
Diseases
- Gliomas[1]
- Papillary Thyroid Cancer[2]
Labs working on this lncRNA
- EEG Room, Department of Neurology, Qilu Hospital of Shandong University, Shandong 250012, China
- Department of Neurology, Qilu Hospital of Shandong University, Shandong 250012, China
- Department of Medical Insurance Office, Qilu Hospital of Shandong University, Shandong 250012, China[1].
- Department of Nuclear Medicine, Shanghai Jiao Tong University Affliated Sixth People’s Hospital, Shanghai, China[2].
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Wang A, Meng M, Zhao X, Kong L. Long non-coding RNA ENST00462717 suppresses the proliferation, survival, and migration by inhibiting MDM2/MAPK pathway in glioma. Biochem Biophys Res Commun. 2017 Apr 1;485(2):513-521.
- ↑ 2.0 2.1 2.2 2.3 Qiu ZL, Shen CT, Sun ZK, Wei WJ, Zhang XY, Song HJ, Luo QY. Circulating Long Non-Coding RNAs Act as Biomarkers for Predicting 131I Uptake and Mortality in Papillary Thyroid Cancer Patients with Lung Metastases. Cell Physiol Biochem. 2016;40(6):1377-1390.
