Difference between revisions of "PLUT"
Jiabao Cao (talk | contribs) (→Function) |
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PLUT:PDX1 associated lncRNA, upregulator of transcription | PLUT:PDX1 associated lncRNA, upregulator of transcription | ||
| − | PLUTO<ref name="ref1" /> | + | PLUTO <ref name="ref1" /> |
| + | |||
===Characteristics=== | ===Characteristics=== | ||
| − | PLUTO is a multi-isoform transcript that contains five major exons that span nearly 100 kb, encompassing a cluster of enhancers that make 3D contacts with the PDX1 promoter in human islets and in EndoC-βH1 cells | + | PLUTO is a multi-isoform transcript that contains five major exons that span nearly 100 kb, encompassing a cluster of enhancers that make 3D contacts with the PDX1 promoter in human islets and in EndoC-βH1 cells <ref name="ref1" />. |
===Function=== | ===Function=== | ||
[[File:PLUTO-func.JPG|right|thumb|400px|'''PLUTO Regulates PDX1 Transcription and 3D Chromatin Structure'''<ref name="ref1" />.]] | [[File:PLUTO-func.JPG|right|thumb|400px|'''PLUTO Regulates PDX1 Transcription and 3D Chromatin Structure'''<ref name="ref1" />.]] | ||
| − | + | PLUTO is involved in the regulation of β cell-specific transcription factor networks <ref name="ref1" />. It is found that PLUTO affects local 3D chromatin structure and transcription of PDX1 (encoding a key β cell transcription factor), and knockdown of PLUTO RNA in dispersed primary human islet cells causes decreased PDX1 mRNA <ref name="ref1" />. | |
| + | |||
| + | Both PLUTO and PDX1 are downregulated in islets from donors with type 2 diabetes or impaired glucose tolerance <ref name="ref1" /> | ||
===Expression=== | ===Expression=== | ||
[[File:PLUTO-1.JPG|right|thumb|400px|'''PLUTO expression'''<ref name="ref1" />.]] | [[File:PLUTO-1.JPG|right|thumb|400px|'''PLUTO expression'''<ref name="ref1" />.]] | ||
| − | PLUTO is the most markedly downregulated lncRNAs in islets from T2D(type 2 diabetes) or IGT(impaired glucose tolerance) donors | + | PLUTO is the most markedly downregulated lncRNAs in islets from T2D (type 2 diabetes) or IGT (impaired glucose tolerance) donors <ref name="ref1" />. |
===Diseases=== | ===Diseases=== | ||
Type 2 diabetes, | Type 2 diabetes, | ||
| − | Impaired glucose tolerance<ref name="ref1" /> | + | Impaired glucose tolerance <ref name="ref1" /> |
===Sequence=== | ===Sequence=== | ||
>NR_047484.2 Homo sapiens PDX1 associated lncRNA, upregulator of transcription (PLUT), long non-coding RNA | >NR_047484.2 Homo sapiens PDX1 associated lncRNA, upregulator of transcription (PLUT), long non-coding RNA | ||
| Line 55: | Line 58: | ||
AAGTGATATCTGTG</dnaseq> | AAGTGATATCTGTG</dnaseq> | ||
==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
| − | *Section of Epigenomics and Disease, Department of Medicine, Imperial College London, London W12 0NN, United Kingdom | + | * Section of Epigenomics and Disease, Department of Medicine, Imperial College London, London W12 0NN, United Kingdom |
| + | * Genomic Programming of Beta Cells Laboratory, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Barcelona 08036, Spain | ||
| + | |||
==References== | ==References== | ||
<references> | <references> | ||
| − | <ref name="ref1"> | + | <ref name="ref1">Akerman I, Tu Z, Beucher A, Rolando DM, Sauty-Colace C, Benazra M, Nakic N, Yang J, Wang H, Pasquali L, Moran I, Garcia-Hurtado J, Castro N, Gonzalez-Franco R, Stewart AF, Bonner C, Piemonti L, Berney T, Groop L, Kerr-Conte J, Pattou F, Argmann C, Schadt E, Ravassard P, Ferrer J. Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks. Cell Metab. 2017 Feb 7;25(2):400-411. </ref> |
| − | Akerman I, Tu Z, Beucher A, Rolando DM, Sauty-Colace C, Benazra M, Nakic N, | ||
| − | Yang J, Wang H, Pasquali L, Moran I, Garcia-Hurtado J, Castro N, Gonzalez-Franco | ||
| − | R, Stewart AF, Bonner C, Piemonti L, Berney T, Groop L, Kerr-Conte J, Pattou F, | ||
| − | Argmann C, Schadt E, Ravassard P, Ferrer J. Human Pancreatic β Cell lncRNAs | ||
| − | Control Cell-Specific Regulatory Networks. Cell Metab. 2017 Feb 7;25(2):400-411. | ||
| − | </ref> | ||
</references> | </references> | ||
Revision as of 10:26, 29 September 2017
Contents
Annotated Information
Name
PLUT:PDX1 associated lncRNA, upregulator of transcription
PLUTO [1]
Characteristics
PLUTO is a multi-isoform transcript that contains five major exons that span nearly 100 kb, encompassing a cluster of enhancers that make 3D contacts with the PDX1 promoter in human islets and in EndoC-βH1 cells [1].
Function
PLUTO Regulates PDX1 Transcription and 3D Chromatin Structure[1].
PLUTO is involved in the regulation of β cell-specific transcription factor networks [1]. It is found that PLUTO affects local 3D chromatin structure and transcription of PDX1 (encoding a key β cell transcription factor), and knockdown of PLUTO RNA in dispersed primary human islet cells causes decreased PDX1 mRNA [1].
Both PLUTO and PDX1 are downregulated in islets from donors with type 2 diabetes or impaired glucose tolerance [1]
Expression
PLUTO expression[1].
PLUTO is the most markedly downregulated lncRNAs in islets from T2D (type 2 diabetes) or IGT (impaired glucose tolerance) donors [1].
Diseases
Type 2 diabetes, Impaired glucose tolerance [1]
Sequence
>NR_047484.2 Homo sapiens PDX1 associated lncRNA, upregulator of transcription (PLUT), long non-coding RNA
000001 TGTGGACAGT GAAAAAGTCG TTTATTAGCT GGACGTCCTG ATAGTCCTCG CTGATACTGG AGGTCCTTGC CGGCCCTCTT 000080
000081 CCCCCTTTCC CTTCACAGAG ACGCGGTTTA CACCCGGGAG AACACAGGTT ACCTTGTTCT TGCTGGACCT TCCACAAGTG 000160
000161 TTTGCACATG ACCTGGAAGA CAGTCAGAGG CAGAAGTCCC TGCAAATGCT CCTGGCTACT TCCTGCAGGC AGCTCATGCT 000240
000241 GCTGCAGCAG AAGACTTTCC TATGTCTAGC TGCCAGTATT CTGGGTGCTG GGGGCATCCT GTTCCTAGGA TCACAGCCAT 000320
000321 GGTGGTATGT TCTAGAACTC AGAAATTTAC CAAATCACTG GATGGACCAG AGGAGTGAGC TCCAGGTTGG GTTTCCAGAA 000400
000401 GGGACTCCCA GAACTCTTCC ACCATACAGG CCTCTCAGGG AGCTGCTCCC TCTGCCATGG TCAGTGAGAG GGGGAAGCAG 000480
000481 GAGCCGCCAT TGGGGTTGTT GAGTTCGTGG CTGCAACCCA GGGATGAGGA AGCTGCTGCT ACACACCCAT GAAGCTGATG 000560
000561 CCTGGACATA AATCCCTACT GATAAGTGTT TACGACATTT CCAGCGTGGT GCCGACACTG CATGGAAATG CTGCATGGAA 000640
000641 AGTCCTTATA CATCTATCTT TGTGCATTTA TTGTGAGCAC CTACTATGAG TAAAACCTGG GCTGGTGGCT GGAGAAACAT 000720
000721 GAAGATGAGT AAGAGCCAAT TCCTGTTCTT GGGGATTTAA TAATATATTC AAGGGAAAAG ACACAAAATA ACCATTTCCA 000800
000801 GGATTCAAGT ATTTTGTTTC GTGCGCATTT CCAACCCATC AAATCAGCTG CAGGCACCGC ACCGTCTAAC AGACCCAGGT 000880
000881 GTTCCTGCTG GAAGAAACTG TCTTTAAGTT TCCCAGAATT GAAGGGGCTT TTCTCGCTTG CTCACGCCCA CTCTTTTGAA 000960
000961 ACCCTAATGG CTGAAGAGCA TCATCAAGAG AAGGGGAAGA TGAAGCTGAC TCCCTGCACC TGCTTCCTCC CCATTCTGTT 001040
001041 GGCTCGGGTC GGTGTGGGCT TTTAGCCTCT CTGAATGTGG AGGTTCCCAG GGATACGGGG AACCACAAAG GTCCATATTC 001120
001121 TCAAATGCAG CACTTCTTAA CCAAGGCATG GCTTTTTCTA GGTGGTCGGA GGCCAAATAC TCTGCTGCTG GCCATCCCAA 001200
001201 CCAGTAGGCA CAGGGAAATG CCAGAAAAGA AGCAGCTGGG GCTTCTCTTG CTGAGGAAGA GGGTGAAATG AACCTTGCTT 001280
001281 GCCGCAGCCA GTTTCTGACC CTGCTGCAGA GATGACGGAT GAGATTCCAG CTGTGATGGA GATGTGGTCC TGGGAGGCCA 001360
001361 TTCTAGGCAC TGCTCTTCAA AGAGGTTGTC TCCATCCTGG GATAGAAGTT CATAAGGGGA AATGTACAAA CACAGTTTTC 001440
001441 CTGCCACCTC CAAGCTGCTT GGGGCCGGAC TGGATGCCCT GCCGGCCCCT CACTCTTCTT ACCTTTGAAC ATCGACCCTG 001520
001521 GCCAGGCATT TGTTTAGGCA GGTTTTCTAA TTTAACTTTT ACAACAACCT GTGAAATGGC TACGATTAAC CCGCTTTCAT 001600
001601 GGCTGAGCAC CTGGCTGGGA GATGTAAGGT ACTTGCCCAA GGAAACCAAT CAATTATCAA CCTGAATTTG CCTGACTTCC 001680
001681 CACTCATGCT TTGGTTGCAG TTCCAGAGTC TGCTACAGGA TCTCCCATAC AGAGTGGCCT GAAGGCACTG GTTTCCCTTG 001760
001761 GGAAACAGCG AACTCATGTC CCTGGACTTC TCCCCTGTGG CCTCCCTCCC TGCTTCCCTG GGACTGTTAG TACCTTCTCC 001840
001841 TATGTTTCAT GTTGACCATA CAGCTTTGCC TTTTTCCAGT CTAGGTTTAT GCCAGACATT GTGTCTGTTA TTTTCCCTTT 001920
001921 TTAAAGTGAT ATCTGGGCTG AGTGCAATGG CTCATGCCTG TAATCCCAGT ACTTTGGGAG GCCAAGGCAG GCGGATCACC 002000
002001 TGAGGTCAGG AGTTCGAGAC CAGCCTGACC AACATGGAGA AATCCCATGT CTACTAAAAA GACAAAATTA GCTGGGCATG 002080
002081 GTGGCAGATG CCTGTAATCC CAGCTATTCA GGAGGCTGAG GCAGAAGAAT CGCTTGAACC TGCGAGGCAG AAATTGTGGT 002160
002161 GAGCAGAGAT CACGCCATTG CACTCCAGCC TGGGCAACAA GAGTGAAACT CTGTCTCAAA AATAAATAAA TAAATAAAAT 002240
002241 AAGTGATATC TGTG
000081 CCCCCTTTCC CTTCACAGAG ACGCGGTTTA CACCCGGGAG AACACAGGTT ACCTTGTTCT TGCTGGACCT TCCACAAGTG 000160
000161 TTTGCACATG ACCTGGAAGA CAGTCAGAGG CAGAAGTCCC TGCAAATGCT CCTGGCTACT TCCTGCAGGC AGCTCATGCT 000240
000241 GCTGCAGCAG AAGACTTTCC TATGTCTAGC TGCCAGTATT CTGGGTGCTG GGGGCATCCT GTTCCTAGGA TCACAGCCAT 000320
000321 GGTGGTATGT TCTAGAACTC AGAAATTTAC CAAATCACTG GATGGACCAG AGGAGTGAGC TCCAGGTTGG GTTTCCAGAA 000400
000401 GGGACTCCCA GAACTCTTCC ACCATACAGG CCTCTCAGGG AGCTGCTCCC TCTGCCATGG TCAGTGAGAG GGGGAAGCAG 000480
000481 GAGCCGCCAT TGGGGTTGTT GAGTTCGTGG CTGCAACCCA GGGATGAGGA AGCTGCTGCT ACACACCCAT GAAGCTGATG 000560
000561 CCTGGACATA AATCCCTACT GATAAGTGTT TACGACATTT CCAGCGTGGT GCCGACACTG CATGGAAATG CTGCATGGAA 000640
000641 AGTCCTTATA CATCTATCTT TGTGCATTTA TTGTGAGCAC CTACTATGAG TAAAACCTGG GCTGGTGGCT GGAGAAACAT 000720
000721 GAAGATGAGT AAGAGCCAAT TCCTGTTCTT GGGGATTTAA TAATATATTC AAGGGAAAAG ACACAAAATA ACCATTTCCA 000800
000801 GGATTCAAGT ATTTTGTTTC GTGCGCATTT CCAACCCATC AAATCAGCTG CAGGCACCGC ACCGTCTAAC AGACCCAGGT 000880
000881 GTTCCTGCTG GAAGAAACTG TCTTTAAGTT TCCCAGAATT GAAGGGGCTT TTCTCGCTTG CTCACGCCCA CTCTTTTGAA 000960
000961 ACCCTAATGG CTGAAGAGCA TCATCAAGAG AAGGGGAAGA TGAAGCTGAC TCCCTGCACC TGCTTCCTCC CCATTCTGTT 001040
001041 GGCTCGGGTC GGTGTGGGCT TTTAGCCTCT CTGAATGTGG AGGTTCCCAG GGATACGGGG AACCACAAAG GTCCATATTC 001120
001121 TCAAATGCAG CACTTCTTAA CCAAGGCATG GCTTTTTCTA GGTGGTCGGA GGCCAAATAC TCTGCTGCTG GCCATCCCAA 001200
001201 CCAGTAGGCA CAGGGAAATG CCAGAAAAGA AGCAGCTGGG GCTTCTCTTG CTGAGGAAGA GGGTGAAATG AACCTTGCTT 001280
001281 GCCGCAGCCA GTTTCTGACC CTGCTGCAGA GATGACGGAT GAGATTCCAG CTGTGATGGA GATGTGGTCC TGGGAGGCCA 001360
001361 TTCTAGGCAC TGCTCTTCAA AGAGGTTGTC TCCATCCTGG GATAGAAGTT CATAAGGGGA AATGTACAAA CACAGTTTTC 001440
001441 CTGCCACCTC CAAGCTGCTT GGGGCCGGAC TGGATGCCCT GCCGGCCCCT CACTCTTCTT ACCTTTGAAC ATCGACCCTG 001520
001521 GCCAGGCATT TGTTTAGGCA GGTTTTCTAA TTTAACTTTT ACAACAACCT GTGAAATGGC TACGATTAAC CCGCTTTCAT 001600
001601 GGCTGAGCAC CTGGCTGGGA GATGTAAGGT ACTTGCCCAA GGAAACCAAT CAATTATCAA CCTGAATTTG CCTGACTTCC 001680
001681 CACTCATGCT TTGGTTGCAG TTCCAGAGTC TGCTACAGGA TCTCCCATAC AGAGTGGCCT GAAGGCACTG GTTTCCCTTG 001760
001761 GGAAACAGCG AACTCATGTC CCTGGACTTC TCCCCTGTGG CCTCCCTCCC TGCTTCCCTG GGACTGTTAG TACCTTCTCC 001840
001841 TATGTTTCAT GTTGACCATA CAGCTTTGCC TTTTTCCAGT CTAGGTTTAT GCCAGACATT GTGTCTGTTA TTTTCCCTTT 001920
001921 TTAAAGTGAT ATCTGGGCTG AGTGCAATGG CTCATGCCTG TAATCCCAGT ACTTTGGGAG GCCAAGGCAG GCGGATCACC 002000
002001 TGAGGTCAGG AGTTCGAGAC CAGCCTGACC AACATGGAGA AATCCCATGT CTACTAAAAA GACAAAATTA GCTGGGCATG 002080
002081 GTGGCAGATG CCTGTAATCC CAGCTATTCA GGAGGCTGAG GCAGAAGAAT CGCTTGAACC TGCGAGGCAG AAATTGTGGT 002160
002161 GAGCAGAGAT CACGCCATTG CACTCCAGCC TGGGCAACAA GAGTGAAACT CTGTCTCAAA AATAAATAAA TAAATAAAAT 002240
002241 AAGTGATATC TGTG
Labs working on this lncRNA
- Section of Epigenomics and Disease, Department of Medicine, Imperial College London, London W12 0NN, United Kingdom
- Genomic Programming of Beta Cells Laboratory, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Barcelona 08036, Spain
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Akerman I, Tu Z, Beucher A, Rolando DM, Sauty-Colace C, Benazra M, Nakic N, Yang J, Wang H, Pasquali L, Moran I, Garcia-Hurtado J, Castro N, Gonzalez-Franco R, Stewart AF, Bonner C, Piemonti L, Berney T, Groop L, Kerr-Conte J, Pattou F, Argmann C, Schadt E, Ravassard P, Ferrer J. Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks. Cell Metab. 2017 Feb 7;25(2):400-411.
