PANCR

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Annotated Information

Approved Symbol

PANCR (PITX2 adjacent non-coding RNA)

Tissue specific expression of PANCR and PITX2c[1]
RNAseq identification of PANCR[1]

Chromosome

4q25

RefSeq ID

XR_939071

Characteristics

PANCR transcript has two exons and it is transcribed from the locus adjacent to PITX2 on chr 4q25 [1]. The entire second exon of PANCR is composed of a long terminal repeat (LTR) in the ERVL-MaLR retrotransposon family [1].

Expression

PANCR is expressed specifically in the left atria and eye, and in no other chambers of the heart [1]. PANCR is coordinately expressed with PITX2c early during cardiomyocyte differentiation from stem cells [1].

Function

PANCR regulates PITX2c expression, as PANCR knockdown decreases PITX2c expression in differentiated cardiomyocytes, altering the transcriptome in a manner similar to PITX2c knockdown [1]. Many miRNAs are significantly up- or down-regulated after PANCR or PITX2c knockdown, suggesting that effects of PANCR knockdown on miRNA expression may be largely mediated by its effect on PITX2c expression [1]. One potential mechanism for the cytoplasmic PANCR lncRNA to regulate PITX2c mRNA is by acting as a miRNA sponge and protecting the binding of specific miRNAs to PITX2c mRNA that would otherwise increase its degradation [1].

Disease

Atrial fibrillation [1]

Conservation

The ORF and the entire PANCR transcript sequence of human are well conserved in chimpanzee with 100% and 98.9% identity, respectively [1].

Labs working on this lncRNA

  • From the Department of Molecular Cardiology, Lerner Research Institute (S.R.G.-P., C.S.M., D.R.V.W., M.K.C.), Department of Cellular & Molecular Medicine, Lerner Research Institute (S.R.G.-P., J.H., J.D.S.), Department of Quantitative Health Sciences (J.B.), and Department of Cardiovascular Medicine (C.S.M., D.R.V.W., M.K.C., J.D.S.), Cleveland Clinic, OH [1].

References

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Gore-Panter, S.R., et al., PANCR, the PITX2 Adjacent Noncoding RNA, Is Expressed in Human Left Atria and Regulates PITX2c Expression. Circ Arrhythm Electrophysiol, 2016. 9(1): p. e003197.

Sequence

>gi|1034642833|ref|XR_939071.2| PREDICTED: Homo sapiens PITX2 adjacent non-coding RNA (PANCR), ncRNA

000001 TTAAAAAGCA TAAAGTAAGG GAGAATTGGA CATCATAATC CCTTAACTAG TAAAATGACT CTAGACAATC GTGAGCTGGA 000080
000081 AACTTCTGTC ATCTACGTGT CTCCCACCCT TTTATACTCC CCTTACCACA CATATTCCCC AAACTAGATT TTTTAAAACT 000160
000161 TCTTTATTTT AATAATATAT TAGGAAATAC TAAAATGTGT TCAGTATCTT ATGAACCCTG ATCATGATTC ACCATCCTAA 000240
000241 AACTGCTCTG ATGTAGGGAA GATGCTGGCA GTGTTGAAAA ACATTATGAC AGAATTTCTG CTAAAGAATT CTTTTACATG 000320
000321 TCTAGTTTGT TTGGAAAAGG ATTAGAAATT AATTAGAATT AATCTGAGAT TCAATTTATG CCAATTCAAT AGACTTTAAT 000400
000401 GTTTTTGAAC TTTTATTTTT GTGAACAAAG ATTTTAATTG TAACATTTGA TCAATAGGCA TTTATTGAAC ATCTACTCCG 000480
000481 TTACAAGGTA TTGTGCCAGG CCACCACAAG AAGCTAAAAA AAAAAAAAGA CCCGCAAAAT CTTAACTCAT AATAAAACAC 000560
000561 CCCATATGGT AATTGCCAAA GGAGTAATAT GGATGAAAGT TAGTTTGGGA GTATGGGAAC AATAATTGCT CAGAAATAAA 000640
000641 ATGAAAAAGT AAAAAGGGAG AGAGTTATGA GATTTAGAAT TAACCTTTAA GTGAGATTTT GGAAGAAGTT AGAAAGGAAA 000720
000721 AGAAGGAACC AAAGGAGGGT GAAATGGGGC AGCCCTTCTG TGGAATAAAA GATGTTTCAA CCAAGTTCTA ATCTAATGAG 000800
000801 TTGCAGGATG ACAATGAAGG TGTTTCTCAA CTGTACAAGG AAGAGAAATC ACATTAAAAT ACTGCCGAGC CAATAAAAAG 000880
000881 AGGATATAAC ACAAGAAAAA CAAATGCATT TGTGTGAAAG ATATGTAAAG TTTAGTACAT CAACTTTATA AACTGTTTCA 000960
000961 GTGTTTTCTT GGAACACACA AATTTGACAA TGTGTGTGAG TCCACAGATG GTAGTTTCAG GAGAGGAGGA GCTTTCAAGG 001040
001041 TGAGAATGGC AAACTGGAGA TTTCCCACTT TGGTGGCCAT AATGCCAATG GTCATATTGC CTGGGCGAAA GAAGCCTGCT 001120
001121 CACTCACTCT CCCAGCCTCT CCAGCATGCA GTGGGGCTTT ATTAAAGAGT GTGCACAGTC CTTTTTGTGC TCTGAAAAGA 001200
001201 CAAGCTATAC AATATTGCAT GCTTTACTTA TTCTACCAGA AACTTGTATT GTTCATAGAA GTACTCCATA TTCATACGTA 001280
001281 CAAATGGTTT ACAGGTAGAC TCTTGACTGA ATAAAATAAT GTATCATACC TGGAAAAGTG AACACTACAA ACAATCTGAA 001360
001361 GCCTTAATTC AAAAGAAAGG ATAAGCAGGG CATAATCCAG GAGCAGCCAA AATTCTGGGG AGAGTCACCT GATGTAGAAG 001440
001441 AAGGGCAATA ATAAAAGGAG GAAATGAAGA AGGTAGAAAA TAAAGGGAAG GTAAAGAAAA GGAATGGAGA GAGACTTCAA 001520
001521 TTTCTCTCAT CCATGAAGCT GTGTTGACAG CTATTCCTAA TCCAGCATTC TCTGACAAGG CATTTTGTAT AAATGTGGTG 001600
001601 TCCAGCAGAG ACTTTGTGTT GCCAGGCTGC TCCAGCCACT GTGGCCTCAT CCTCTCTCCA CCTCCATGGT GGCACCCCAC 001680
001681 CCAGATTCCT TTCTTGTCAA ACTTGTTTCC AGTCACCCAA GCCCTCTAGT CTGTGACCTC TTGGTCAAAC TGTCTGTTAC 001760
001761 CCAGGACACA AATAGATCGA GGGTGTCAGA TAACATGGTA ATTTGGTGGG GGAGAAGAGG GTTTGAGTGA ACACTGCAAT 001840
001841 ACCCTTTAGA ATACTCCTTT CCCCAACTAC TCAAACCCTT AAAAGTAAAT GCCCTTTCTC CACCTATGTT TCTCTGTCTC 001920
001921 TAAGTCACTG AAAAGCAACT GAGCGTGTGA TTCATACTTC TTTGTATTTA TTTGCTTCGA TGCATTCATT GTCTCTCTAG 002000
002001 AGCTAACTTA GTGGAACATT TGAGTCAATT CTATTTTTCT TGGGAGAGTG GAATAACATA AAGTTGGGTG CTGACGAAGT 002080
002081 TGATCTGTAT TGCTCTGTAG GAATGACATA GAGCATTGTG TGCACTGCAG TTAGAGCAGC GACACTACAT GAAGTGATGA 002160
002161 ACACTCTGTA ACCACATCTT AAACAGAAAG CCATTTTCTC TGAGAACGAA CTGATTGGTG ATGTCCAATT AATACACATA 002240
002241 CACAGCACTT GTCACATTGT TGATGCCTGC TGAGACTCTG GAAAGCCTTG TTTACTGCAT GTCTCCGCTG CCACCCTCCA 002320
002321 TCCCCTGCCA GAAATTCTCA GGATCACTAT ACAGGCTGTG AACACACTGA AGCAGGAGCA GTGGCCTTTG AAGAAGCTAG 002400
002401 GATGTGACCT TGAGAGTAAT GCAACGATGC AGCGTTCTCA GCAGACATGC ACACCAGCAC AGCCACTTTC TCACACCCCT 002480
002481 AAGTATAGAG ATTTGAGTGA ATGCTCTCAG CAAAACTTCT GTTCCAATAA ACAAGTCAGA GGTAGGGTCC AGGTTGAGGC 002560
002561 GGAGTGTGCC ATCTGTTCAA AATATATATA TATATATATA TATATATAGT GTGTGTATAT ATATATACAG ATACACACAC 002640
002641 ACTAAGAGGT TATAATGAGT CAGGCATGCA TTTAAATAAA ACTATTTTGT ATAAGAAAAA AAGAATCTTC TTAAGAGGTA 002720
002721 CAGGAATTGC TCTGCAGGTT GGCTGGCAAT TCCTGAAAGC CCTAATAATA TCACATCTCC CTTTTGCTTG CACCCACCTT 002800
002801 ATCTCAGATT TTTCTTCAAT GGGGGCGGGG GACGGGGGGA ACAGAGGTTA GGCAGAGGGA GAGAGACAGA GATACAGAAA 002880
002881 CAGAATCATC TTCCTATTCA GGAATTTGCT CAGTGCCTGA GTCAGTAATG TTTCCAGGTG AGGGCACAGG AACTTAGGAT 002960
002961 GTGCACTGTC TTGAATTCTT CCTTCAGCTC TGTTATCTTT TGGTAAATTC TGTATATTTT GACTGGGCAC GTGGGCCTAG 003040
003041 CACATAAGTC AGTGCAGACG TATCATTTTA CTTTCCATTA CTTATGTGTA AAGAAAAAAC AAATAGGTCA GAGTCGGAAG 003120
003121 GAGGCAGGGT CCAGACCAGT TGTGGGTGGG ATCGGATAGG AGCCTAGGAC TTCAGCGCGA CCTCAAGCCA GGACTTCTGC 003200
003201 GAGGTCTCAG GTCCGAGGGC CAGGTCGGGC GCCGGTTGCA CCGCCCACCG CGCGCCTCCC CTTCGTCCCC AGGCCCTGGT 003280
003281 CCGGGGCTCT TGCTGCCACT CCCAACCCAC TGAGCCCTGC CTCCTGGGAT CCCACCCCGG GCGCCAGGGA TGGCAGCAGA 003360
003361 GCGACCTTTC TCGGCCCTGT GGACAGCCGC TCCTCCTAGA CTCCAGCTTT CCCCCACTAA CTTTTATAAG AGATGAAAAG 003440
003441 CTGTTCACAC GTTCTCAAGT GTGAAAGAAA AGGAAATTCT CTTGTGTTAG AAGCCCTGAA CCTCAAACTC CGCAAGGAGA 003520
003521 ACGGTTGACT CAGTCACCCC CCTTCCTCCA GTCCCTCATT TGTCCTCCGC TTCCTGCGGC TGAACGGTCC TTGATAAGTG 003600
003601 GCCTCCAGAA GATTCGGTAC TTTGGGCCAG GGGCAAGGCT GGGGCTGCTC TAGGTGCAGA ACTCTCTATA GGTCCTCTCT 003680
003681 CCCAGGACCG GATAGATGAT TCATTTTTAT ACGTAACGTT TTACCCCAGT CTATTCCCGC AGCTGGTTAA TGTTCAACCC 003760
003761 CCGGGCCTCG AGAGGCAGCT CCAAGGAGGC AGGCAGGCAT GACCCATTCA AGGTATATGG CTGCTCGGGA GTGAAGGCGC 003840
003841 GGAGGCCCGA GAAAGGATAA ACAAGACACC GCCTCATCAG ATAAGAACGT CTCCTTCGAT GTCACGGATT TCAAGAGGTA 003920
003921 GCTGGAGAAA CTGACGTCAG GAGTGTCCTG TGAATGAACA TCGCCCGAGG CCTAGCACCC ACAGAAGAAG GGTTCTATTT 004000
004001 TACTCTACTT TGCTTGATAT TATTTATTTT CTAACAAAGT GATCCGTAGT CTGCAACCTT AGGCTCTGAC AGGCAAAGCC 004080
004081 CATTTCTTAG CTCTGGGGAT GGCTTGCAGG GTCTCCACCT CTGTCCACTT TGGTGTCCTC TTTCTCCCTT CGGCTCCCCA 004160
004161 CCTCCATCCC CCGAGCCCAC ACACAGCGGG GTGAAGCTGT CGGGGAGACT CGTGGGCAAC CAAATGCAGG CACCCTCTGA 004240
004241 AGAGACGCCG AGAAGGCCCT GCATTCGATC CGGGAGGACA TAGAAAGATG CCATGAAGTT CTATTGGGTG CAGCAAGCCG 004320
004321 TTCCCCACGC ACACTCCCCG TGATACCTGC CCAGAGAAGC AGAAGCAGTT TCGAGGGCTG TTGACACAGG CAGAGCGGGG 004400
004401 AAACGCGCCC AAGAATTGGG CTGCCACTGG TATGGGTCCC AAGTCACATT CAATAAGCTG CCCACCGCTT TCTGGGGGAC 004480
004481 AGCAGTGGTG GTTCTAGGTC TCATCTTTCC AGAGCGACGA GGATAAAAGT TCCTGCCCAG GACTGTGTGC GAGGGGGTCC 004560
004561 CGCACTGCTG CAAACTCTCA GCGGAGGCAG AGAGGCTTTG CTGTTTCTGG AGAGAGGAAG CATTGGCAGA GGCAGTCTCC 004640
004641 GGGCTGTGAG GAATCCACCC TCATGCCTTA GTGTGGGTAC GTCAGGTCCC AGCATCAGCG GGCCATTTCC TCAGTTGCAT 004720
004721 GAATGGAGGA AAAACCAAAC CAAACCAAAC CAAACCAAAC CAAACCAAAC CAAACCAAAC CTTGGCTGTG GACAAAGAAA 004800
004801 ACAGGAGAGG GAGAGGATGG AGGAGAAAAA GAGCACGAGG GAGGGCAAAC ACCTTAAACA TTTTTTGCCG TAAGACTAGA 004880
004881 AGAACTAGGT CTGGAAAGAT CCATCAAAGT CCCAGGGTGC AGACACACAC CCTGCCCAGG GAGAGCCCAG TGAGTCTGAA 004960
004961 CTTCTCTTAG TCCTTCTGAA GGAAGGAAAT TTAAAAAGCA CCTCTCACTA CCACCAAAAA GTAAACACTT TTACCATGTA 005040
005041 GTCATTA

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Internal error - LncRNAWiki

Internal error

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[XS42IfZamopWDb36SaZQlAAAACo] 2019-07-16 20:40:03: Fatal exception of type "TypeError"

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