ODC1-DT
ODC1-DT a c‐Myc‐activated long non‐coding RNA and suppress tumorigenesis.
Contents
Annotated Information
Name
ODC1-DT: ODC1 divergent transcript (HGNC nomenclature), lncRNA-MIF [1].
Characteristics
ODC1-DT is five exon transcript of 882 bp long non-coding RNA, located on human chromosome 2p25.1.
Function
ODC1-DT plays an important role in inhibiting aerobic glycolysis and tumorigenesis [1].
ODC1-DT functions as a tumor suppressor to inhibit cell proliferation and cell cycle progression [1].
ODC1-DT increases Fbxw7 expression by acting as a molecular sponge for miR‐586 and subsequently decreases c‐Myc and c‐Jun expression [1].
ODC1-DT inhibits the glycolysis via miR‐586 [1].
Expression
ODC1-DT expression level was higher in head and neck carcinoma than normal tissues [1].
Regulation
ODC1-DT expression is positively regulated by c‐Myc. [1].
Diseases
- Head and neck carcinoma [1]
Labs working on this lncRNA
- CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science & Technology of China, Hefei, Anhui, China. [1]
References
Sequence
>gi|101929715|ref|NR_110597.1| Homo sapiens ODC1 divergent transcript (ODC1-DT), long non-coding RNA
000081 CCAGCTCTTC CTGGAGCAGG CACGACTTCC ACAGAAACAG AGCAAACGCT AGCCGTAAGC AGAAAGAACG TTATAGCTCC 000160
000161 AGCGCTGAAT GAGACATCTT TGATTCTGTG GTGATGCGGA CTTTGTGCCT CTCTGTGAGG AATCACTTTG TTCCAATGAC 000240
000241 GCAATTTTCC TCACACTCCG GAAGTGTCCT GCACTGCCAG AATCGCCCAG CTTCCCGGCA CACCTATCAA CCAGTCGTTC 000320
000321 CCAGCACTGC CCAGTATGCA GCCTCCAGGC AGAGGGCCTG GATGTCTTGG CAGGTGTTTC CGAAAAATCC AATCCACCCT 000400
000401 CCAAGGTGGA AAGTGTGCCA TCTCTGCCCA TAATCCAAAT GGCGTGCCTG AGGCATAGAA AGCAGCTTTC AGGGAGGCCT 000480
000481 TCCTTCCTCT GAGCAATGGT GGCATCATCA GAAAAGTGGA GCTCCTCCAA AAGGATCTGC TGGAAGCAGA GGACGCCCAT 000560
000561 GTCGCCTGGT GACTCCCTCT GACCCAACAA GTTGCAGCAC CTCTGCTGGG CTTTGCCACT GCCCCATTTT TGCCAGAGCC 000640
000641 TCACCCTGGT GGGGCCCCAC CTCTGGGAAG CCCCAGCGCC TGCAAGATTT TTTCCTCTCG TGACAGGGAG CAGCATGCGG 000720
000721 AGGGCCCTTG CACAACCTGG GTCTTCAGGA AGTTCCTTGC CCAGGTGTTG GCCCAGCTCT CTTCATGGTT CCAAGAAGGC 000800
000801 TGCCCCAGGA AGGCTTGTGG ACAGAGGGAG AAGCATCTCT TCCTCTATGT CTCTTTTTAT CTAAGAAACC AGTTTGACCA 000880
000881 GC
