NONHSAT091315

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Annotated Information

Name

LOC285194

Features

Together with the noncoding RNA BC040587 and the tumor suppressor gene LSAMP (limbic system-associated membrane protein), LOC285194 is present in the focal region of chr3q13.31 (osteo3q13.31), which is the most altered region in osteosarcomas. These genes are proposed to be cooperatively acting tumor suppressors.

Recurrent focal copy-number changes and loss of heterozygosity (LOH), which usually involves loss of LOC285194 and BC040587 expression, implicate these ncRNAs in ostecosarcoma. Focal osteo3q13.31 CNAs and LOH are also common in cell lines from several other cancers (such as lung, autonomic and central nervous system, blood, endometrium, soft tissue, skin, gastrointestinal tract, urinary tract, and breast).

Depletion of LOC285194 by siRNA promoted proliferation of normal osteoblasts (with a mild increase in the G1 population) by cell-cycle transcripts (Cyclin D1, VEGF, and VEGFR1 up-regulation, and cyclin A2 and cyclin B1 suppression) as well as regulation of apoptotic genes (such as suppression of BCL2 and BimEL pro-apoptotic genes).

Genetic deletions of LOC285194 or BC040587 in tumor DNA were also associated with dramatic decrease in survival of osteosarcoma patients.

Characteristics

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Function

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Expression

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Conservation

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Misc

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Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

Annotation originally sourced from lncRNAdb.

Basic Information

Transcript ID	NONHSAT091315
Source	NONCODE4.0
Same with	,
Classification	intergenic
Length	2105 nt
Genomic location	chr3+:116428635..116435887
Exon number	4
Exons	116428635..116429268,116431202..116431704,116432886..116432997,116435035..116435887
Genome context
Sequence	000001 GGGGTACCAA AGTCCACTCT GAGCTTTTCC TCTGGGAACA GATCCCAGAT TATTCCAGAC TTAAGACATG GAGATATATC 000080 000081 TTGCTAGAGG TAGGAAGATG ATAAGATCAG TTTCTATAGG TAGAGGATAA TGTGTCCTAA AATGTAGGTA GAGATAAGTC 000160 000161 TGACAGTGGT TTAGACAAAA AGGGCCTCTG CTAATGGTGG AGAGATCAAG GAAGAAAAGA GCAACGTTAA AGTGAGGCTG 000240 000241 TACCCACAGA TCATGCTCAA GCAAATTCGA ACCGTGAGCG CATTTCTCTT AAACAATGAA CACTTAGAAT AAAAATTAAA 000320 000321 ATTTCCCACA AATTTCTAAT TTTAAAATAG TTTCCCAAGA TTTCAGTGGT ATTGTATATA TGCCCATATA ATTTTTTGGA 000400 000401 TTACTATTCC CACAAGTGTA AGATGAAAGA GGACCTGCCC TCCATTCTAT CTACTCCCTC TCTGCAAAGG CCATTTTGAA 000480 000481 GATCTCAGTT TTACTGAAAG GGGTCTGCCA CACATAACTT CCCTGGTGTA CCAGCAACAA GTGTTCAGTG GACCATGGCA 000560 000561 ACACAAAGAA TGACGGAGGA GAGAAAATGC CATGCAGAAG TGATAGTCAA GATGAAGATG TGGGAGAGGA GCAGCCCCCA 000640 000641 GTATATATTC AGTGTGTCCT CTGAAGTAAC AACCATCCCA TCTGGCTGAG AAGTGATGGA CACGGCTCCT TAACCACACT 000720 000721 GTACCCTCTG TTCTTGGCAC CTCTCTACCA GAAAGATATC AACAAATTGG ATGGAATTCA GAGAACAGTA AGAAAAATGA 000800 000801 TTAAAGAGAT GGAGGCAGTG ACTTATGAGG AAAGATGAAA AGGACTAAAT CTATGTAGCT TGGCAAAGCA ACAACTGAGG 000880 000881 TGGCGTATGA AAACTGTCTA CAAGCATTTG AAGAATATAA ACACCAAGGG AAGAGAGGGA ACTTTTTAGA ATGGTCTGGG 000960 000961 GAATAAGCAG AGTAAGAGGA CAGAATTGAA GAAAGGAGAG AGATATGCTA AGTTGGGGGT GGGGGCGTTT TCTCATCAAT 001040 001041 TGTAAATTTT GATAAATAAC AAAATTAAGT CTGGAGAGAA AGAGTTGCAT CTCATGCTTT TAGGTTACAA TCAGTGTTGA 001120 001121 CCTGCACTGA GAAAATGTGA CTTCCTATTA TCCTTCTCAA AGTTATTGCT GCAGAGGAAA GAAGCATACA TCTTTTACCC 001200 001201 ACCAGGAAAC CCCCAAAGCA TCTATTACCA TAATAGCCAT GGGAAACAGA AGGCACCTCA AATAAAGGTG GGGAAAAGAA 001280 001281 TGAAAGAAAT GGCTTTGGCC TGTGCCTGTT TGACCTCTGA GAGATACTTT TTGCAAGAAA TTGTTAAGTT TTGGCCCAAA 001360 001361 AAGTGGTCGG TCTTTTATCC TTCCTTGTGG AGGCCAAACT GCAAACCAGG ATGAAGAAAC CATCAGTGGC AGTTTGGGGA 001440 001441 GGTGGAGGAG GGACTATCTA GACTCAGTGA ATCACCAAGG AAACATGAGG CCTATTTCTC TGTGAAGCTG AACTTCAAAA 001520 001521 AACAATCTAA GAGATACAAA GGGAAAAGTG TGACTGCTCT GACAGCAAAA ACAAGCAAAT ATCTCCAGAG GGGATTAATC 001600 001601 CTTCTGCTTC AAAGTAACTA AAACAAAGAA AGCTGAGCCA GCTTCACTGG AAACAACACC TGTCCATCAG ACAAGGATGA 001680 001681 GCTAATCAAA AGAAAACACT GCCTATGTGC ACGACTCAGC AGCCTGGACA GCTAATACCA AGGAACACGT TTTCACTATA 001760 001761 AAGATTCAGC TTTCAAAATC CAGTTCCCTC TTGTAGAGCC ACAGGGTTAA AAGGGACCTT AGAGATCATC TACATACAGG 001840 001841 CCAAACCCTC AATGAATGCC AGTGTTCGCC TTATGTTCTT CTTGCCGGAC TCTTTTCTGG CCTCTGTTCT GTCAGGATGT 001920 001921 TTCCTGTTTT GCAAAACAGC TTTAATCCTT GAGTATATTT AATTGTTAGA AAACAGTTCC TCAAATTTGA CCCCAAATTT 002000 002001 AAGTCTAATT TATGAAGAAA GTTTTGCCTT TGGAGACAGG TTTAATTTTA CTTCCATGTG GAAAACCTTC AAATAAAATG 002080 002081 ATGACTATTG TGTACTCACG AAAAA

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