Difference between revisions of "NONHSAT087635"
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==Annotated Information== | ==Annotated Information== | ||
| + | ===Name=== | ||
| + | EGO: Eosinophil granule ontogeny (EGO) RNA | ||
| + | |||
| + | ===Characteristics=== | ||
| + | Two isoforms: ~1.0kb unspliced EGO-A and ~1.5 kb spliced (two exons) EGO-B. | ||
| + | |||
| + | Transcribed antisense from a conserved intron of ITPR1 gene. | ||
| + | |||
===Transcriptomic Nomeclature=== | ===Transcriptomic Nomeclature=== | ||
Please input transcriptomic nomeclature information here. | Please input transcriptomic nomeclature information here. | ||
===Function=== | ===Function=== | ||
| − | + | Proposed to affect myeloid development by regulating eosinophil gene expression, as knockdown of EGO in vitro in CD34+ cells decreases eosinophil granule protein MBP (major basic protein) and EDN (eosinophil derived neurotoxin) mRNA levels. | |
===Regulation=== | ===Regulation=== | ||
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===Expression=== | ===Expression=== | ||
| − | + | Highly expressed in human bone marrow CD34+ cells and BMMC (bone marrow mononuclear cells). Highly upregulated during eosinophil development from CD34+ human hematopoietic stem cells before returning to basal levels within 72 hours. Despite a return to basal levels, EGO transcripts were present and inducible in mature eosinophils. | |
| + | |||
| + | ===Conservation=== | ||
| + | EGO and some of surrounding sequence is conserved. However the presence of EGO has not been investigated outside of humans. | ||
===Allelic Information and Variation=== | ===Allelic Information and Variation=== | ||
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}} | }} | ||
[[Category:Intergenic]] | [[Category:Intergenic]] | ||
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Revision as of 07:46, 9 October 2014
Please input one-sentence summary here.
Contents
Annotated Information
Name
EGO: Eosinophil granule ontogeny (EGO) RNA
Characteristics
Two isoforms: ~1.0kb unspliced EGO-A and ~1.5 kb spliced (two exons) EGO-B.
Transcribed antisense from a conserved intron of ITPR1 gene.
Transcriptomic Nomeclature
Please input transcriptomic nomeclature information here.
Function
Proposed to affect myeloid development by regulating eosinophil gene expression, as knockdown of EGO in vitro in CD34+ cells decreases eosinophil granule protein MBP (major basic protein) and EDN (eosinophil derived neurotoxin) mRNA levels.
Regulation
Please input regulation information here.
Expression
Highly expressed in human bone marrow CD34+ cells and BMMC (bone marrow mononuclear cells). Highly upregulated during eosinophil development from CD34+ human hematopoietic stem cells before returning to basal levels within 72 hours. Despite a return to basal levels, EGO transcripts were present and inducible in mature eosinophils.
Conservation
EGO and some of surrounding sequence is conserved. However the presence of EGO has not been investigated outside of humans.
Allelic Information and Variation
Please input allelic information and variation information here.
Evolution
Please input evolution information here.
You can also add sub-section(s) at will.
Labs working on this lncRNA
Please input related labs here.
References
Please input cited references here.
Basic Information
| Transcript ID |
NONHSAT087635 |
| Source |
NONCODE4.0 |
| Same with |
, |
| Classification |
intergenic |
| Length |
1529 nt |
| Genomic location |
chr3-:4790876..4793274 |
| Exon number |
2 |
| Exons |
4790876..4791694,4792630..4793274 |
| Genome context |
|
| Sequence |
000001 caacttctgg gcaaggcaga ggtgggtttg gctttttaaa aattttttca gcctgtcctc atggaactac atattctttt 000080
000081 ctaagaactt ttcatcctaa cctccctact cacatcttct aagtgtctct gctctggtgg gaatgtgatg gacaacacag 000160 000161 agccatctca gaagcctctg tggccaccac caggccggcc agggtgcagg gggccactcc ctgggcagcc atagggttct 000240 000241 cagcaaggtg cattcgtcgt ccctgctgag aatctgatgg ggcagcattt ttttttttaa ttaaatgcaa gctgagtcat 000320 000321 ttcaacctgc aaccttcagg taacaggagt tacccaagct ccaggaatta tgattgtggg gtaaacccat tctcttgttt 000400 000401 tcttgcggtt ctattttata acgcactaga ggagacagag acgtcattgc ttcacccagg gcaagaggac aaaggaggat 000480 000481 gcatggaaat acaaacagcc cttctcctcc aggccatacc gactgtccaa ctagcaacag acttcacctg gttttggagc 000560 000561 aatctgaatt tggaatatgc cagagaaaac ttctatcagg caagatggaa gactcctagg ataggtctct ctcatggagg 000640 000641 gattggcacg atggtaagag tccagtggat ggaaaaggcc tcctccttaa agatggtgat ggaaacgagc actgcacagg 000720 000721 gaaacacaaa tcaggtcccc tgaaatccag cccaacctgg ccagaccctc cagtgcccat cagggcttat gaacagggtg 000800 000801 cttcagtgtc tttgttaggg gtggttaaaa aggagcacgt gcttataggg gatgctgctg agctccatga ttttgacttc 000880 000881 ctgtctaacc tgttgatgct acaaaactct tttaaaaaca gttaccatgg gaacttttcc ctagcaagca ttcttcaaga 000960 000961 aacgttacag gtgctggtga attcaatgcc cttggtgtca ataagctttt gctgagtctt agaatgtgtg gcttgaactg 001040 001041 agaggacttt caaacagata atgcgaagtt tccaatgcaa atgtcttcgg ggttaagtgt cagtgaagtg cagtggaagg 001120 001121 tagggggata aaatgatctc agtgtatatg gaggccccac ttaagcattc aaaaaattct atatacagtg ttttcaatgt 001200 001201 attatgtatc agcaaaacaa aataccccat agggctataa tcagctcagg gggtcacctc agcaagagat gctctggcta 001280 001281 tcactcctac tacgggattt cctctctcat cagaaccagt aggtggtcaa aaccacaata atgcataaat gaaggcaggg 001360 001361 aattgggtat ccaatgtgag caactgaaaa ggtgccatgt attagctatt tgccattatg gttctgcaag tgctcagatg 001440 001441 actcataaaa tgaccagaac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 001520 001521 aaaaaaaaa |
