NONHSAT080206

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Annotated Information

Transcriptomic Nomeclature

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Function

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Regulation

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Expression

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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Basic Information

Transcript ID	NONHSAT080206
Source	NONCODE4.0
Same with	,
Classification	intergenic
Length	1020 nt
Genomic location	chr20+:47894715..47905797
Exon number	5
Exons	47894715..47895253,47895641..47895745,47897022..47897107,47897440..47897501,47905582..47905797
Genome context
Sequence	000001 CGGGGGCCCA GGGTGGAGAG CACGAGGGCC TGGCCCAGGC ACGGCCGGCG CCTCCGCCCT CGAGGAGGGC GTCACCTCAG 000080 000081 CTCCCCCCGG CGGCGGAGCC GGCGGGCTCA GGCGGGCGCG GCTGAGGGGA GCGGACCGCG GGGGGCGGGA GATGACTGCG 000160 000161 CCCAAGGCCT TTGCGGGCCT CAGCCGGCCC CAGAGGAAGG GGAACCCGTC GAGCGGTTTG GTGCGTGTGA AGCGCGACAT 000240 000241 GGCGAGGAAG CGGACAAGCC CGGGTGGCCC GGCGTGTAGA GGGAAGGGGG CGGGGCTAGA CGCGGCCTGG ACAACTACTA 000320 000321 GAGCGCCTCG GGCTGTGCTG CTCGAGACTA CATTTCCCAG AGCGACGCGC GCGGAGCGGG CGGGAAAGAG AGCGTTTCGG 000400 000401 GTCCAGTGCG CAGGTGCGAA AGCCATCTTT GGTTATATAA GGGAGGTTCA GGAAGCCATT CGTTCTTTCG CGTCTGCGGT 000480 000481 GCCCGGAGTG TGGTACTTCT CCTAGTTGCA GTCAGGCTTC ATACGCTATT GTCCTGCCCG TTAGAGCAGC CAGCGGGTAC 000560 000561 AGAATGGATT TTGGAAGAGG GAGTCACCAC TGGACCTCCA AGGAAGCCAC GTGCAGACAT CTACAACCTT CGATCTCCTG 000640 000641 ACGAGTTTAT TGTTGGCCAA AACCAGGCTT TGATTGAACC AGGATGAATG CGGGTGTTGG AAGTAGAATA TATATATACA 000720 000721 TATAAAATTG GTTGGGAGCC ACGTGTACCA GTGTGTGTTG ATCTTGGCTT GATTCAGTCT GCCTTGTAAC AGAAACTGGC 000800 000801 GATGGAATAT GAGAGGAGCC CTCTGGAAAG AAAAGGACAG ACCCTGTGCT TTCATGAAAG TGAAGATCTG GCTGAACCAG 000880 000881 TTCCACAAGG TTACTGTATA CATAGCCTGA GTTTAAAAGG CTGTGCCCAC TTCAAGAATG TCATTGTTAG ACTTTGAAAT 000960 000961 TTCTAACTGC CTACCTGCAT AAAGAAAATA AAATCTTTTA AATCAAAAAA AAAAAAAAAA

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Annotation (From lncRNAdb)

[NONHSAT080206]

Section	Description
ID	Zfas1
Characteristics	Expressed from a bi-directional promoter with the protein-coding gene Znfx1. Zfas1 5°Ø is antisense to 5°Ø of Znfx1. Spliced, polyadenylated. SnoRNA host gene, contains 3 intronic C/D box snoRNAs. Human orthologue is alternatively spliced.
Expression	Highly expressed and differentially expressed during mammary development. Strongly down-regulated during lactation compared to pregnancy and then up-regulated again during involution. Znfx1 coding gene,in contrast, was more lowly expressed and was not differentially expressed during mammary gland development. Expressed in the epithelial cells of the mammary gland ducts and alveoli. Zfas1 is widely expressed in mouse tissues including brain, liver, lung, kidney, spleen, heart and embryo, showing higher expression than Znfx1. Zfas1 extremely stable with a half life of >32 hrs in N2A (neuroblastoma) cells. Compared to a half life of 50 minutes for Znfx1. The increased stability of Zfas1 may explain why its expression level is much higher than Znfx1. However, in mouse 3T3 and embryonic stem cells Zfas1 stability was much lower with a half-life of 1.7 hr and 63 min respectively, while the human ZFAS1 had a half-life of 3 hr in B-cells (Friedel (2009), Sharova (2009), Clark (2012)). These results suggest there is significant regulation of Zfas1 stability both within and between species (Clark (2012)). Localised to both the nucleus and the cytoplasm. Human ZFAS1 expression is reduced in ductal carinoma compared to normal tissue.
Function	Zfas1 appears to have a role in mammary gland proliferation and differentiation. - Zfas1 knockdown in a HC11 cell culture model of mammary differentiation showed increased differentiation and a probable increase in proliferation. Knockdown had little effect on intronic snoRNA expression suggesting the Zfas1 host transcript is functional. - Zfas1 knockdown appears to affect Znfx1 expression.
Conservation	Syntenic transcription observed in multiple mammals. Low conservation of Zfas1 sequence between human and mouse compared to snoRNAs, but Zfas1 has potential secondary structural similarities.
Name	Zinc finger antisense 1

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