NONHSAT040039

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Annotated Information

Name

DIO3OS: DIO3 opposite strand/antisense RNA (head to head) C14orf134,NCRNA00041, DIO3-AS1

Characteristics

Antisense and head to head with Dio3 from the Dlk1-Dio3 imprtinted locus (Hernandez (2004)). A large number of isoforms are transcribed through alternative splicing and start sites some of which overlap Dio3 (Hernandez (2004)). Also overlaps a provisional microRNA miR1247.

Function

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Expression

Various DIO3OS isoforms are expressed in a wide range of human tissues including adult testis, adrenal cortex, heart, bladder, uterus, placenta and fetal lung (Hernandez (2004)). Expressed in embryonic and extra-embryonic tissue in mouse. Weakly expressed in several neonatal and adult tissues: brain and liver (adult only), intestine and tougue (neonate only), kidney and lung (expressed in both) (Tierling (2006)). Analysis in different cell culture lines showed co-expression of DIO3OS transcripts and DIO3 (Kester (2006)). Conversely differentiation of mature brown adipose tissue (BAT) adipocytes from precursor cells showed that Dio3 was only expressed in the proliferating precursors while a specific Dio3os isoform was expressed only in differentiated adipocytes (Hernandez (2007)). Not imprinted in mouse (Tierling (2006)).

Conservation

Aside from the short exon 1, there is poor sequence conservation and no conserved ORFs between mouse and human Dio3os (Hernandez (2004)).

Misc

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Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

Annotation originally sourced from lncRNAdb.

Basic Information

Transcript ID	NONHSAT040039
Source	NONCODE4.0
Same with	,
Classification	intergenic
Length	1746 nt
Genomic location	chr14-:102023641..102026759
Exon number	2
Exons	102023641..102025171,102026589..102026759
Genome context
Sequence	000001 CCGCTTGCCT CGCCCAGCGC AGCCCCGGCC GCTGGGCGCA CCCGTCCCGT TCGTCCCCGG ACGTTGCTCT CTACCCCGGG 000080 000081 AACGTCGAGA CTTGAGCGCC CGAACTGAGC CACCTTCGCG GACCCCGAGA GCGGCGGCGC GACTCACCGC GGAGGCGCCC 000160 000161 GGACGCGTCA AGCCCAGCCC AATAAGAAGC ACCTGATCCA CACTCTTTCT AGCCCCAGGG ATGCTCAGGA AAGCAGCCTT 000240 000241 TCTTTAGGGC TGTCATCTGT TCTGGGGATC TGTTGCTGTT TCTTGGGCCC ACAGAATACA CTCCACACCT CGGGACTCCA 000320 000321 TAATATTGGA CAAGGCTGGA AGGCCCATTT GGCTCCTGCA GCCTCTTATG CAGGTGAGGA CAGACCCAAG GTCCAGGCAA 000400 000401 TGCTGGCCTT TGGAACACAG AACCTGGCTC ACTGACTCCC ACTCCAGTTG TCTTTTCCCT CTGCCTCTGG AGCAACCCTC 000480 000481 TCTCCTCCAG AGCAACCCCT GTCCCTCCTT CCTACCTCTC TCTAGGGCTG CACCCCCAGC TCACCTTAGA CCTGGCCCTT 000560 000561 CCTACCTGTT GCCCCTACTG TCTTGTCCCA TCCCAGTGGT CAGGAGGGAG AGTACTGGCC AAAGGCCCAG CTCCACCTGT 000640 000641 GACTTAGGGG AGTGCCAGGC ATCACCCAGA GGTCCCGGCC CTCGGGGGCC TGGCAGGCTC TGCTGTGGGG GAAGCAGAGT 000720 000721 TAGAACTGGG GCTGCTTCTC CTGTCCCCCA GCCTGGCTGG GCCTCCCCCA CCTCCCTTTC TGCCTGCCCT CTTACAACTC 000800 000801 CAGCAGGGGG CGGGCAGGGG AAAGAAAAGG AGGGACAAGT TGGATGGGGT CCATTTGGTG TCCAGGAACA ACTTGGAGAG 000880 000881 AGGCGGGGAG GGGACAGGCA GCAGGGCCCT GGCAGAGCCA GGGGAGGGCT GGCCTTTGGA TGGCCTTCTG ATCCCAAGCC 000960 000961 CATCCTCCTG GGGCAGTCTT CCCTTGAAAG GGAGGGTTTG GTGAACCCTG GTGCGGACCC CCCCGCCGGA CCTCACTGCC 001040 001041 CCAGTGCGGG GCGTGGTAGG CGGGTTTGCA ATGGGTACAG CCTCTCTCTC CATTCCAGTA GAGCAGCTCC CAGGGCCCAG 001120 001121 AGAGGCTGTC ACTGAGACTT CCCTCTGGGG TGGGGTGGGT TCTGGTGGCC CTGTGTTCCC CTGCAGGAGG ACCTCCTGAG 001200 001201 GCTTCGGGCA GGAGCTGGTG CACACCTGGA GGAGAGTGCT GGTGAATGGC AGGTGTGTGC CTCAGTGTCC TTGCTGCCAG 001280 001281 GGTGTCAGCC CTGCTTCACC ACTGGCCGTT TGTCTCTGTC CCCTCCACTG GCCTCTTGAA GCACAGAGAC CCTCCGGGTA 001360 001361 CTTTCCTTCC TCTGGGCTTC CACTCATGCT ATTCCCTGCT CCCTTTTTCT ACCTGGAGAC CCCCATTCCT CCTCCTCCTC 001440 001441 TGCTGCCCTC ACCTCCACCT GGGCCCTCCC AGCTCCCGGG AGATGGCTGA ACCCCACTCC CCACCCGCTA GTCATCCTCT 001520 001521 TCAGCGGTCC TCCCAGAGCT GTCCTCAGCA TGGCAGCCTC CACAGCCCCT GGGTGTCACC CCCGGTTTCG TGTCTGCCTC 001600 001601 GGACTCCAGA CCTGCCCCTC CCAGGCTGGC CCAGATGGAT CCTCTACAGT GACTAACCCA AACCAGCACC AGGCAGGGAC 001680 001681 CCAATAAACC TTTGTGAATG GAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAA

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