NONHSAT015489
Annotated Information
Approved symbol
FAS-AS1
Previous symbols
"FAS antisense RNA (non-protein coding)", "FAS antisense RNA 1 (non-protein coding)", FAS-AS, FASAS, SAF
Chromosomal location
10q24.1
Characteristics
FAS-AS1 is 1556 bp long and is entirely originated from intron 1 of the Fas gene.[1] FAS-AS1 binds to RBM5 and interferes with RBM5-mediated skipping of exon 6.[2]
Expression
FAS-AS1 expresses in heart, placenta, liver, muscle, kidney and pancreas.[1] The expression of FAS-AS1 in lymphoma is repressed by promoter hyper-methylation.[2]
Conservation
FAS-AS1 appears to be conserved among the primates and is absent in the rodents.[1]
Diseases
- B-cell lymphoma
Function
FAS-AS1 regulates skipping of exon 6 through direct interaction with RBM5 reveals a novel layer of modulation of the Fas death receptor signaling in human lymphomas.[2]
Transcriptomic Nomeclature
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Allelic Information and Variation
Please input allelic information and variation information here.
Evolution
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Labs working on this lncRNA
- Division of Cancer Research, National Health Research Institutes, Taipei, Taiwan, ROC [1]
- Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.[2]
References
- ↑ 1.0 1.1 1.2 1.3 Maurillo, L., G. Del Poeta, A. Venditti, F. Buccisano, A. Battaglia, S. Santinelli, T. Caravita, A. M. Epiceno, B. Del Moro, A. Tamburini, A. Picardi, G. Suppo, G. Catalano, A. Bruno, and S. Amadori. "Quantitative Analysis of Fas and Bcl-2 Expression in Hematopoietic Precursors." Haematologica 86, no. 3 (2001): 237-43.
- ↑ 2.0 2.1 2.2 2.3 Sehgal, L., R. Mathur, F. K. Braun, J. F. Wise, Z. Berkova, S. Neelapu, L. W. Kwak, and F. Samaniego. "Fas-Antisense 1 Lncrna and Production of Soluble Versus Membrane Fas in B-Cell Lymphoma." Leukemia 28, no. 12 (2014): 2376-87.
Basic Information
| Transcript ID |
NONHSAT015489 |
| Source |
NONCODE4.0 |
| Same with |
, |
| Classification |
intergenic |
| Length |
1554 nt |
| Genomic location |
chr10-:90751179..90752732 |
| Exon number |
1 |
| Exons |
90751179..90752732 |
| Genome context |
|
| Sequence |
000001 TTCCAAGTAA TTAGCACTTT GCATCTATTT TATTTATTGC TACTACTAAG AAAACATAAC CGTGAAGGCA TAAAAGCAAA 000080
000081 CATTTTCTGT AGACACATGA GGTGACACAA GAGTGTTGAA ACTTCTTTAA GGATAAAGGC CTGATGTTAG GCATGTCGTG 000160 000161 AGCGCAAAAC CAATTTCTGT GTAACTAAAT TTAAAAGAGT CATATTAGAG GGGAGAAATG GAAGATAAAC TGCAAAACGT 000240 000241 AAACAATGAT TACTTAGGTG ATAGAGTTAT GTCTGATCTT TGTATTTGAC TCATCTGCAT TTATAAATTT TATTTAATAA 000320 000321 GCCTTAATTT CCTAGGCCAT ATATCATATA CAAATATAAG TTATACCTAA CTTATAGGTA TTATAATATG TATATATACA 000400 000401 TAAATGTATG AATATTTACA TATGCGTGTG TGTGTGTATT CTTTCAGAAA AGCAAAGTTT TCTTCGGGCT TTAAACACGC 000480 000481 AGCCTCTGGT AAAGGTGCTA TTGGTACAAA AGTTCAACAA GCATAGCTCC AAGCTTTGAC AATTTTCTTA CACTTTACTA 000560 000561 ATACTGCTGT CCAAAAACTA TGAGATTTTC AAAGCAGCCA ACATTGCAGT GGTGCAATGG TTAATAACAA GAGAGAGAAG 000640 000641 AGTGTGGCCT GAGGTTGTAT AAATGTTTTC TCAATCTTGA ATCATTAATT TTCTCCAAGG AAGTTTCTAA AGAATCCCAA 000720 000721 ATAGTGCACA CTATTTCTGA AAGGAACAGG ATTTTTTTTT CTAATCATAA AATGGACCCA GACATCTCAG CCTCTTGGTG 000800 000801 TAATCTGGAT ATCAGATGCA ATCAGCGAAC AGCCTGAGTT TTGGAATTAG ATCTGAGTTC AATCCCATAT CTCCCATTTA 000880 000881 CTAGCTGTGT GATCTTGGCT GAATTACTGA AGCTCTCTGA ACCTCATTTC GCCATCTGTA AAATGGGGAT GTGGTTATCT 000960 000961 TCCCCACTAC ATGGCTCTCG TGAGAATCCG CGGAGATCAC ATTTGTAAAC ACTTCTCTCG CTATGCCTGG CACTTTGTTG 001040 001041 GGGCCCAATA AAATAAAAAT CCATGGACTC TCAGAGGCTC CGGTACTCAA ATGAGCCTCC TGGATCCACG TCTCTTTGAT 001120 001121 TAGCCATCTG CAAGCTGGCA TTTCTGAGCG AGGGACTTTT CAAAACAGGC TGCTCAAGTT TCTTGGCCAA TAATAGGCGC 001200 001201 CGGGTTCTGT GCGGTGGGAA CGAGTACCAC CAACCCCAGC AGGAGACCAA GCAGAAATCA CCATGGGAGT GCAAGCTAAG 001280 001281 AAAGGGCAAA AGAAGAAAGA GAAGGGCAGA AAAACAAAAC AAAATGAAAC CACTCAGGCA GCGACTTACA GTCTTAAAGA 001360 001361 GAGAATTCCC GGAAGGGAGA CAAGGCAGTT TCTTTTTCTG TGTGACAATA AAAAACGGTA AACAAGCCTC CAGAAGCTCA 001440 001441 TTCAGCCCCC ATATAACTTT TTCGAGAAAG AAAAGGTGCC GTTCTTCCGA GCCCTCCGGC TTAACCACTG CTTCGGTGCT 001520 001521 GACTTATTTC CTACGTCTGA GAACTGCCAG AAAA |
