Difference between revisions of "NONHSAT015489"

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==Annotated Information==
 
==Annotated Information==
 +
===Name===
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SAF
 +
 +
===Characteristics===
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1556 bases; transcribed from the opposite strand of intron 1 of the human Fas gene.
 +
 +
===Function===
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In vitro over-expression of Saf protects cells from Fas-mediated apoptosis.
 +
 +
Over-expression of Saf induces alternative splicing of FAS transcripts, wherein an alternative exon overlapped by the antisense RNA is retained and non-adjacent 3' exons are skipped. This results in Fas proteins that are not able to anchor to the cell membrane, therefore regulating Fas-mediated but not TNF-alpha-mediated apoptosis.
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===Expression===
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Detected in several human tissues (such as heart, placenta, liver, muscle and pancreas, as well as kidney in lower levels). It was also detected in different cancer cell lines, including Jurkat (acute T-cell leukemia), MES-SA (uterine carcinoma) and U-937 (Histocytic Lymphoma); moderately expressed in CA46 (Burkitt,s lym- phoma), Raji (Burkitt,s lymphoma) and only slightly expressed in MG-63 (osteosarcoma).
 +
 +
===Conservation===
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Saf gene appears to be conserved among the primates and is absent in the rodents.
 +
 +
===Misc===
 +
Please input misc information here.
 +
 
===Transcriptomic Nomeclature===
 
===Transcriptomic Nomeclature===
 
Please input transcriptomic nomeclature information here.
 
Please input transcriptomic nomeclature information here.
 
===Function===
 
Please input function information here.
 
  
 
===Regulation===
 
===Regulation===
 
Please input regulation information here.
 
Please input regulation information here.
 
===Expression===
 
Please input expression information here.
 
  
 
===Allelic Information and Variation===
 
===Allelic Information and Variation===
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You can also add sub-section(s) at will.
 
You can also add sub-section(s) at will.
 
 
==Labs working on this lncRNA==
 
==Labs working on this lncRNA==
 
Please input related labs here.
 
Please input related labs here.
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}}
 
}}
 
[[Category:Intergenic]]
 
[[Category:Intergenic]]
 
{{lncrnadb|
 
tID = NONHSAT015489|
 
ltID = SAF|
 
ann = <tab class=wikitable sep=tab head=top>
 
Section Description
 
ID SAF
 
Characteristics 1556 bases; transcribed from the opposite strand of intron 1 of the human Fas gene.
 
Expression Detected in several human tissues (such as heart, placenta, liver, muscle and pancreas, as well as kidney in lower levels). It was also detected in different cancer cell lines, including Jurkat (acute T-cell leukemia), MES-SA (uterine carcinoma) and U-937 (Histocytic Lymphoma); moderately expressed in CA46 (Burkitt°Øs lym- phoma), Raji (Burkitt°Øs lymphoma) and only slightly expressed in MG-63 (osteosarcoma).
 
Function In vitro over-expression of Saf protects cells from Fas-mediated apoptosis. Over-expression of Saf induces alternative splicing of FAS transcripts, wherein an alternative exon overlapped by the antisense RNA is retained and non-adjacent 3' exons are skipped. This results in Fas proteins that are not able to anchor to the cell membrane, therefore regulating Fas-mediated but not TNF-alpha-mediated apoptosis.
 
Conservation Saf gene appears to be conserved among the primates and is absent in the rodents.
 
</tab>|
 
}}
 

Revision as of 06:58, 10 October 2014

Please input one-sentence summary here.

Annotated Information

Name

SAF

Characteristics

1556 bases; transcribed from the opposite strand of intron 1 of the human Fas gene.

Function

In vitro over-expression of Saf protects cells from Fas-mediated apoptosis.

Over-expression of Saf induces alternative splicing of FAS transcripts, wherein an alternative exon overlapped by the antisense RNA is retained and non-adjacent 3' exons are skipped. This results in Fas proteins that are not able to anchor to the cell membrane, therefore regulating Fas-mediated but not TNF-alpha-mediated apoptosis.

Expression

Detected in several human tissues (such as heart, placenta, liver, muscle and pancreas, as well as kidney in lower levels). It was also detected in different cancer cell lines, including Jurkat (acute T-cell leukemia), MES-SA (uterine carcinoma) and U-937 (Histocytic Lymphoma); moderately expressed in CA46 (Burkitt,s lym- phoma), Raji (Burkitt,s lymphoma) and only slightly expressed in MG-63 (osteosarcoma).

Conservation

Saf gene appears to be conserved among the primates and is absent in the rodents.

Misc

Please input misc information here.

Transcriptomic Nomeclature

Please input transcriptomic nomeclature information here.

Regulation

Please input regulation information here.

Allelic Information and Variation

Please input allelic information and variation information here.

Evolution

Please input evolution information here.

You can also add sub-section(s) at will.

Labs working on this lncRNA

Please input related labs here.

References

Please input cited references here.

Basic Information

Transcript ID

NONHSAT015489

Source

NONCODE4.0

Same with

,

Classification

intergenic

Length

1554 nt

Genomic location

chr10-:90751179..90752732

Exon number

1

Exons

90751179..90752732

Genome context

Sequence
000001 TTCCAAGTAA TTAGCACTTT GCATCTATTT TATTTATTGC TACTACTAAG AAAACATAAC CGTGAAGGCA TAAAAGCAAA 000080
000081 CATTTTCTGT AGACACATGA GGTGACACAA GAGTGTTGAA ACTTCTTTAA GGATAAAGGC CTGATGTTAG GCATGTCGTG 000160
000161 AGCGCAAAAC CAATTTCTGT GTAACTAAAT TTAAAAGAGT CATATTAGAG GGGAGAAATG GAAGATAAAC TGCAAAACGT 000240
000241 AAACAATGAT TACTTAGGTG ATAGAGTTAT GTCTGATCTT TGTATTTGAC TCATCTGCAT TTATAAATTT TATTTAATAA 000320
000321 GCCTTAATTT CCTAGGCCAT ATATCATATA CAAATATAAG TTATACCTAA CTTATAGGTA TTATAATATG TATATATACA 000400
000401 TAAATGTATG AATATTTACA TATGCGTGTG TGTGTGTATT CTTTCAGAAA AGCAAAGTTT TCTTCGGGCT TTAAACACGC 000480
000481 AGCCTCTGGT AAAGGTGCTA TTGGTACAAA AGTTCAACAA GCATAGCTCC AAGCTTTGAC AATTTTCTTA CACTTTACTA 000560
000561 ATACTGCTGT CCAAAAACTA TGAGATTTTC AAAGCAGCCA ACATTGCAGT GGTGCAATGG TTAATAACAA GAGAGAGAAG 000640
000641 AGTGTGGCCT GAGGTTGTAT AAATGTTTTC TCAATCTTGA ATCATTAATT TTCTCCAAGG AAGTTTCTAA AGAATCCCAA 000720
000721 ATAGTGCACA CTATTTCTGA AAGGAACAGG ATTTTTTTTT CTAATCATAA AATGGACCCA GACATCTCAG CCTCTTGGTG 000800
000801 TAATCTGGAT ATCAGATGCA ATCAGCGAAC AGCCTGAGTT TTGGAATTAG ATCTGAGTTC AATCCCATAT CTCCCATTTA 000880
000881 CTAGCTGTGT GATCTTGGCT GAATTACTGA AGCTCTCTGA ACCTCATTTC GCCATCTGTA AAATGGGGAT GTGGTTATCT 000960
000961 TCCCCACTAC ATGGCTCTCG TGAGAATCCG CGGAGATCAC ATTTGTAAAC ACTTCTCTCG CTATGCCTGG CACTTTGTTG 001040
001041 GGGCCCAATA AAATAAAAAT CCATGGACTC TCAGAGGCTC CGGTACTCAA ATGAGCCTCC TGGATCCACG TCTCTTTGAT 001120
001121 TAGCCATCTG CAAGCTGGCA TTTCTGAGCG AGGGACTTTT CAAAACAGGC TGCTCAAGTT TCTTGGCCAA TAATAGGCGC 001200
001201 CGGGTTCTGT GCGGTGGGAA CGAGTACCAC CAACCCCAGC AGGAGACCAA GCAGAAATCA CCATGGGAGT GCAAGCTAAG 001280
001281 AAAGGGCAAA AGAAGAAAGA GAAGGGCAGA AAAACAAAAC AAAATGAAAC CACTCAGGCA GCGACTTACA GTCTTAAAGA 001360
001361 GAGAATTCCC GGAAGGGAGA CAAGGCAGTT TCTTTTTCTG TGTGACAATA AAAAACGGTA AACAAGCCTC CAGAAGCTCA 001440
001441 TTCAGCCCCC ATATAACTTT TTCGAGAAAG AAAAGGTGCC GTTCTTCCGA GCCCTCCGGC TTAACCACTG CTTCGGTGCT 001520
001521 GACTTATTTC CTACGTCTGA GAACTGCCAG AAAA
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