Difference between revisions of "NALT1"
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NALT1 | NALT1 | ||
===Approved Name=== | ===Approved Name=== | ||
| + | [[File: NALT.jpg|right|thumb|400px|'''NALT promoted cell proliferation in vitro and in vivo.''' <ref name="ref1" />.]] | ||
NOTCH1 associated lncRNA in T-cell acute lymphoblastic leukemia 1 | NOTCH1 associated lncRNA in T-cell acute lymphoblastic leukemia 1 | ||
===Previous Symbols=== | ===Previous Symbols=== | ||
MIR4674HG, LINC01573 | MIR4674HG, LINC01573 | ||
===Synonyms=== | ===Synonyms=== | ||
| − | |||
TCONS_l2_00029132 | TCONS_l2_00029132 | ||
===RefSeq ID=== | ===RefSeq ID=== | ||
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===Ensembl ID=== | ===Ensembl ID=== | ||
ENSG00000237886 | ENSG00000237886 | ||
| − | + | ||
| − | |||
===Characteristics=== | ===Characteristics=== | ||
| − | NALT is located in the upstream of NOTCH1, within a spacing of 10 kb. | + | NALT is located in the upstream of NOTCH1, within a spacing of 10 kb.<ref name="ref1" />. |
===Cellular Localization=== | ===Cellular Localization=== | ||
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===Expression=== | ===Expression=== | ||
| − | Increased expression of NALT dramatically promoted cell proliferation in cell lines via CCK8 assay and EDU stain. | + | Increased expression of NALT dramatically promoted cell proliferation in cell lines via CCK8 assay and EDU stain.<ref name="ref1" />. |
===Sequence=== | ===Sequence=== | ||
Latest revision as of 13:42, 30 June 2016
Contents
Annotated Information
Approved Symbol
NALT1
Approved Name
NOTCH1 associated lncRNA in T-cell acute lymphoblastic leukemia 1
Previous Symbols
MIR4674HG, LINC01573
Synonyms
TCONS_l2_00029132
RefSeq ID
NR_121577
Ensembl ID
ENSG00000237886
Characteristics
NALT is located in the upstream of NOTCH1, within a spacing of 10 kb.[1].
Cellular Localization
A nuclear long noncoding RNA [1].
Function
NALT promoted cell proliferation in vitro and in vivo [1].
NALT activated the transcription of NOTCH1.[1].
Regulation
Results provided strong evidence that the NOTCH1-dependent regulation by NALT might occurred in the stem cells in the development of T ALL [1].
Diseases
- pediatric T cell acute lymphoblastic leukemia
Expression
Increased expression of NALT dramatically promoted cell proliferation in cell lines via CCK8 assay and EDU stain.[1].
Sequence
>gi|652699776|ref|NR_121577.1| Homo sapiens NOTCH1 associated lncRNA in T-cell acute lymphoblastic leukemia 1 (NALT1), long non-coding RNA
000081 TGCGGCCGGG TGCACAGGCC CGAGGGAAGC ACAGGCCTCG GCCTCCCAGC TCCCAACCCC TGCACCACCC ACAGCCGGGA 000160
000161 GTACCCCATG GACAGCTGTG GCCGAGGAGA AGCCAGGGAT GAGGGGGATG GGCCTCACCT CCCCACCAGC CTGGGAAGGG 000240
000241 GGTAGGCCCC TGGCAAGTAG GAGGGAAGCT GAGGCTCAGA GACATCATGA GGATGCCAGC TCAAGGCCCA GCCAGGCCTT 000320
000321 GGTCCTCAGC TGCTGTCATC CAGTAGGCTC AAGCCCAGAG GCCTCCAGGG TGTCCAGCCT CCAGGGTGCC TCCTACGCAG 000400
000401 CCTCCACGTC CCCATCCACT GCAGCCCCTG ACCATCGGGC ACACCGTGGG GCCTTCGCTG GCCGCCGGGC CTCAGGTTCT 000480
000481 GCTGCACCAA GTGATTTTTA AAGCCCCATC TGCCTTTCTC CACTTATAAA GAACTTGGGA CATTTC
Labs working on this lncRNA
- Department of Hematology and Oncology, Nanjing Children's Hospital Affiliated with Nanjing Medical University, Nanjing 210008, China.
