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Welcome to LncRNAWiki
105,824 human long non-coding RNAs inside
Introduction

LncRNAWiki, a component of ScienceWikis, is a wiki-based, publicly editable and open-content platform for community curation of human long non-coding RNAs (lncRNAs), viz., a community-curated resource of lncRNA knowledge. Unlike conventional biological databases based on expert curation, lncRNAWiki harnesses collective intelligence to collect, edit and annotate information about lncRNA, quantifies users' contributions in each annotated lncRNA and provides explicit authorship for each contributor to encourage more participation from the whole scientific community.

Imagine a world in which every single person on the planet has free access to the sum of all human knowledge. — Jimmy Wales, Founder of Wikipedia

Disease
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LncRNAWiki keeps frequent updates by community annotation of human lncRNAs and integration of newly identified lncRNAs with experimental evidence.

In contrast to the previous version (released in 2014) that had 86 curated lncRNAs, the updated version has, a total of 719 lncRNAs that are community-curated (the detailed list is available at Featured LncRNAs).

Among these 719 lncRNAs, 304 have been experimentally proved to be associated with cancer and other diseases (Disease).

Top diseases and top cancers, and the lncRNA numbers are listed.

Data source
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The majority of the lncRNA information was initially seeded with a subset of information from GENCODE, NONCODE, LNCipedia, and lncRNAdb(purple circle indicates lncRNAdb).


Classification
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We classified lncRNAs into seven groups (Intergenic, Intronic (S),Intronic (AS),Overlapping (S),Overlapping (AS), Sense and Antisense) based on their genomic location in respect to protein-coding genes (Ma etal. 2013, RNA Biology). Help


Small protein
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We developed computational approaches for identification of small proteins in all the human lncRNAs in LncRNAWiki.

As a result, we identified 9,387 lncRNAs potentially encoding small proteins and we further validated 2,246 such small proteins with high confidence by considering protein instability, secondary structure and transmembrane helix (lncRNAs and small proteins, Help).


How to Cite

If you use any data or information in your work, please cite the following primary publication:

Related publication:

About Us
Our group works in the field of Computational Biology and Bioinformatics (CBB), currently with a particular focus on building biological knowledge wikis in aid of community curation of massive biological knowledge.
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