LncRNAWiki is a wiki-based, publicly editable and open-content platform for community curation of human long non-coding RNAs (lncRNAs), viz., a community-curated lncRNA knowledgebase. Unlike conventional biological databases based on expert curation, lncRNAWiki harnesses collective intelligence to collect, edit and annotate information about lncRNAs, quantifies users' contributions in each annotated lncRNA and provides explicit authorship to encourage more participation from the whole scientific community.
Imagine a world in which every single person on the planet has free access to the sum of all human knowledge. — Jimmy Wales, Founder of Wikipedia
- Featured lncRNAs: LncRNAWiki keeps frequent updates by community annotation of human lncRNAs and integration of newly identified lncRNAs with experimental evidence. In contrast to the previous version (released in 2014) that had 86 curated lncRNAs, the updated version has, as of 28 June 2016, a total of 719 lncRNAs that are community-curated (the detailed list is available at Featured LncRNAs). Moreover, among these 719 lncRNAs, 633 are newly reported in recent publications, while 289 have been experimentally proved to be associated with cancer and other diseases (e.g., BANCR). Newly featured lncRNA:AATBC,ABALON, APOA1-AS, APTR, BANCR, BDNF-AS, BLACAT1, BPESC1, CAHM, CASC8, CCAT1, CCAT2,CISTR, CRNDE, CYYR1-AS1, DALIR, DANCR, DBET, DHRS4-AS1, DLEU1, DLEU2, ERICD, ESRG, FENDRR, FIRRE,FOXCUT, FTX, GHET1, GHRLOS, GPR1-AS, HAGLR, HEIH, JADRR, KANTR, LINC-PINT, LINC00163, LINC00312, LINC00850, LINC01191, LSINCT5, LUCAT1, MIR22HG, MIR31HG, MIR99AHG, MIR100HG, MIR155HG, MIR222HG, MIR503HG, MYCNUT, NAMA, NRIR, OVAAL, PACERR, PART-1, PAUPAR, PCA3, PCAT1, PCAT4, PCAT7, PRNCR1, PTCSC2, PTCSC3, PVT1, PWRN1, PWRN2, RASSF1-AS1, SCAANT1, SCHLAP1, SENCR, TARID, WFDC21P (see more)
- Small proteins:Considering the potential functional significance of lncRNA-encoded small proteins (Anderson, D.M. et al. Cell, 2015; Nelson, B.R. et al. Science, 2016), we developed computational approaches for identification of small proteins in 105,824 human lncRNAs. As a result, we identified 9,387 lncRNAs potentially encoding small proteins and we further validated 2,246 such small proteins with high confidence by considering protein instability, secondary structure and transmembrane helix (lncRNAs and small proteins, help). All putative small proteins as well as their relevant information on physical and chemical parameters, secondary structures, transmembrane helices and topology structures are integrated into LncRNAWiki (e.g., ENST00000608917.1) and also publicly available at Downloads. Expanding LncRNAWiki by this information provides a very new quality for lncRNA researchers.
- BLAST lncRNAs: If a lncRNA is newly reported in a published paper but is not found in LncRNAWiki after BLAST, please consider to create a new page for this lncRNA to obtain its authorship in LncRNAWiki. See here for help.
- Community curation: Community-curated efforts are quantified and rewarded by giving explicit authorship. Please share your expertise and perform curations to have the authorship for lncRNAs of your interest.