Difference between revisions of "Main Page"

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<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">Classification</div>
 
<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">Classification</div>
 
<div style="padding:0.5em 0.5em;">[[File:web2a.png|center|410px]]  
 
<div style="padding:0.5em 0.5em;">[[File:web2a.png|center|410px]]  
The majority of the lncRNA information was initially seeded with a subset of information from [http://www.gencodegenes.org/ GENCODE], [http://www.bioinfo.org/noncode/ NONCODE], [http://www.lncipedia.org/ LNCipedia], and [http://www.lncrnadb.org/ lncRNAdb], and we classified these lncRNAs into seven groups ('''Intergenic''', '''Intronic (S)''','''Intronic (AS)''','''Overlapping (S)''','''Overlapping (AS)''', '''Sense''' and '''Antisense''') based on their genomic location in respect to protein-coding genes (Ma etal. 2013, RNA Biology). [[Help:Contents#Database content|''Help'']]
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The majority of the lncRNA information was initially seeded with a subset of information from [http://www.gencodegenes.org/ GENCODE], [http://www.bioinfo.org/noncode/ NONCODE], [http://www.lncipedia.org/ LNCipedia], and [http://www.lncrnadb.org/ lncRNAdb], and we classified these lncRNAs into seven groups based on their genomic location in respect to protein-coding genes (Ma etal. 2013, RNA Biology). [[Help:Contents#Database content|''Help'']]
 
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LncRNAWiki keeps frequent updates by community annotation of human lncRNAs and integration of newly identified lncRNAs with experimental evidence.  
 
LncRNAWiki keeps frequent updates by community annotation of human lncRNAs and integration of newly identified lncRNAs with experimental evidence.  
  
In contrast to the previous version (released in 2014) that had 86 curated lncRNAs, the 2017 updated version has, a total of 948 lncRNAs that are community-curated (the detailed list is available at [[LncRNAWiki:Featured|Featured LncRNAs]]).  
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In contrast to the previous version (released in 2014) that had 86 curated lncRNAs, the 2017 updated version has, a total of 948 lncRNAs that are community-curated ([[LncRNAWiki:Featured|Featured LncRNAs]]).  
 
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We developed computational approaches for identification of small proteins in all the human lncRNAs in LncRNAWiki.  
 
We developed computational approaches for identification of small proteins in all the human lncRNAs in LncRNAWiki.  
  
As a result, we identified '''9,387''' lncRNAs potentially encoding small proteins and we further validated '''2,246''' such small proteins with high confidence by considering protein instability, secondary structure and transmembrane helix ([[LncRNAWiki:small proteins|lncRNAs and small proteins]], [[Help:Contents#Database content|Help]]).  
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As a result, we identified '''9,387''' lncRNAs potentially encoding small proteins and '''2,246''' among them are with high confidence ([[LncRNAWiki:small proteins|lncRNAs and small proteins]], [[Help:Contents#Database content|Help]]).  
 
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<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">How to Cite</div>
 
<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">How to Cite</div>
 
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* BIG Data Center Members: [http://nar.oxfordjournals.org/content/early/2016/11/28/nar.gkw1060.full '''The BIG Data Center: from deposition to integration to translation'''.] ''Nucleic Acids Research'' 2017, accepted and in press.
 
* BIG Data Center Members: [http://nar.oxfordjournals.org/content/early/2016/11/28/nar.gkw1060.full '''The BIG Data Center: from deposition to integration to translation'''.] ''Nucleic Acids Research'' 2017, accepted and in press.
 
* Lina Ma, Vladimir B. Bajic, Zhang Zhang. [https://www.landesbioscience.com/journals/rnabiology/article/24604/?nocache=227993923 '''On the classification of long non-coding RNAs'''.] (2013) ''RNA Biology'', 10(6),924-933.
 
* Lina Ma, Vladimir B. Bajic, Zhang Zhang. [https://www.landesbioscience.com/journals/rnabiology/article/24604/?nocache=227993923 '''On the classification of long non-coding RNAs'''.] (2013) ''RNA Biology'', 10(6),924-933.
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<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">About Us</div>
 
<div style="padding:0.5em 1em;">Our group works in the field of [http://cbb.big.ac.cn Computational Biology and Bioinformatics] (CBB), currently with a particular focus on building biological knowledge wikis in aid of community curation of massive biological knowledge.
 
 
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Revision as of 02:51, 28 June 2017


Welcome to LncRNAWiki
105,824 human long non-coding RNAs inside
Introduction

LncRNAWiki is a wiki-based, publicly editable and open-content platform for community curation of human long non-coding RNAs (lncRNAs), viz., a community-curated lncRNA knowledgebase. Unlike conventional biological databases based on expert curation, lncRNAWiki harnesses collective intelligence to collect, edit and annotate information about lncRNAs, quantifies users' contributions in each annotated lncRNA and provides explicit authorship to encourage more participation from the whole scientific community.

Imagine a world in which every single person on the planet has free access to the sum of all human knowledge. — Jimmy Wales, Founder of Wikipedia

Disease
Wordcloud1.png

Top 10 Diseases

213 Neoplasms

39 Nervous System Diseases

33 Congenital, Hereditary, and Neonatal Diseases

21 Musculoskeletal Diseases

21 Hemic and Lymphatic Diseases

21 Mental Disorders

19 Cardiovascular Diseases

15 Nutritional and Metabolic Diseases

15 Endocrine System Diseases

10 Skin and Connective Tissue Diseases

Top 10 Cancers

36 Breast Cancer

31 Prostate Cancer

30 Hepatocellular Carcinoma

28 Gastric Cancer

26 Lung Cancer

18 Colorectal Cancer

12 Esophageal Squamous Cell Carcinoma

12 Bladder Cancer

9 Glioma

9 Lung Adenocarcinoma

Among these 948 featured lncRNAs, 404 have been experimentally proved to be associated with cancer and other diseases (Disease).

Top diseases and top cancers, and the lncRNA numbers are listed.

Classification
Web2a.png

The majority of the lncRNA information was initially seeded with a subset of information from GENCODE, NONCODE, LNCipedia, and lncRNAdb, and we classified these lncRNAs into seven groups based on their genomic location in respect to protein-coding genes (Ma etal. 2013, RNA Biology). Help


Featured lncRNA
caption

LncRNAWiki keeps frequent updates by community annotation of human lncRNAs and integration of newly identified lncRNAs with experimental evidence.

In contrast to the previous version (released in 2014) that had 86 curated lncRNAs, the 2017 updated version has, a total of 948 lncRNAs that are community-curated (Featured LncRNAs).


Small protein
SmallPRO-1.png

We developed computational approaches for identification of small proteins in all the human lncRNAs in LncRNAWiki.

As a result, we identified 9,387 lncRNAs potentially encoding small proteins and 2,246 among them are with high confidence (lncRNAs and small proteins, Help).


How to Cite

If you use any data or information in your work, please cite the following primary publication:

Related publication:

Visitor Statistics

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