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{|style="width:100%; margin-top:10px; background-color:#f6f6f6; border:1px solid #d2d2d2; margin-bottom: 10px;"
 
{|style="width:100%; margin-top:10px; background-color:#f6f6f6; border:1px solid #d2d2d2; margin-bottom: 10px;"
 
|style="width:50%; text-align:center; white-space:nowrap; color:#000"|
 
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<div style="font-size:180%; border:none; margin:0; padding:.5em; color:#000;">Welcome to LncRNAWiki</div>
 
<div style="font-size:180%; border:none; margin:0; padding:.5em; color:#000;">Welcome to LncRNAWiki</div>
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<div style="padding:0em; font-size:100%">[[:Category:Transcripts|106,053]] human long non-coding RNAs inside</div>
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<div style="padding:0em; font-size:100%">[[:Category:Transcripts|106,063]] human long non-coding RNAs inside</div>
  
 
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*[[:Category:Transcripts|LncRNA Transcripts]]
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*[[:Category:Transcripts|Transcripts]]
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*[[:Category:Genes|Genes]]
 
*[[LncRNAWiki:Classification|Classification]]
 
*[[LncRNAWiki:Classification|Classification]]
 
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|style="width:18%;|
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*[[:Category:Genes|Genes]]
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*[[LncRNAWiki:Featured|Featured LncRNAs]]
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*[[Special:BLAST|BLAST]]
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*[http://bigd.big.ac.cn/lncbook/disease Disease]
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*[http://bigd.big.ac.cn/lncbook/function Function]
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*[[LncRNAWiki:Download|Downloads]]
 
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*[[LncRNAWiki:FAQ|FAQ]]
 
 
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*[[File:New5.png]][[LncRNAWiki:Featured|Featured LncRNAs]]
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*[[LncRNAWiki:Small_proteins|Small Proteins]]
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*[[File:New5.png]][[LncRNAWiki:Small_proteins|Small Proteins]]
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*[http://bigd.big.ac.cn/lgc Prediction]
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*[[File:New5.png]][[LncRNAWiki:Disease|Disease]]
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*[http://bigd.big.ac.cn/lncbook/blast BLAST]
 
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<!---------------welcome Box----------------->
 
<!---------------welcome Box----------------->
 
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<div style="padding:1em 0.5em;">
 
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{{LncRNAWiki:Summary}}
 
{{LncRNAWiki:Summary}}
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<div style="padding:0.2em 0.5em;text-align:center;font-weight:bold;color:#2d2d2d;">''Imagine a world in which every single person on the planet has free access to the sum of all human knowledge. — Jimmy Wales, Founder of Wikipedia''</div>
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<div style="padding:0.2em 0.5em;text-align:center;color:#2d2d2d;"> ''LncRNAWiki, an important component of '' [http://bigd.big.ac.cn/lncbook '''LncBook'''], ''provides community annotations of human lncRNAs''</div>
 
</div>
 
</div>
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----
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|}
  
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|}
 
 
<!--------------main part one---------------->
 
<!--------------main part one---------------->
 
{|border="0" cellspacing="0" cellpadding="0" style="margin:1em 0; background:transparent; width:100%;"
 
{|border="0" cellspacing="0" cellpadding="0" style="margin:1em 0; background:transparent; width:100%;"
 
|-
 
|-
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<!-----------Featured lncRNAs------------>
 
<!-----------Featured lncRNAs------------>
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|valign="top" style="border:1px solid #66B3FF; background-color:transparent; "|
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|valign="top" style="border:1px solid #66B3FF; background-color:transparent;width:50%;"|
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<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">Featured lncRNAs</div>
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<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">[http://lncrna.big.ac.cn/index.php/LncRNAWiki:Featured Featured lncRNAs]</div>
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<div style="padding:0.5em 0.5em;">[[File:Featured2.png|left|560px|caption]]  
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<div style="padding:0.5em 0.5em;">[[File:Featured-2019-3.png|center|500px|link=LncRNAWiki:Featured]]</div>
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===<u>Top 10 Diseases</u>===
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<!-----------Top 10 lncRNA-associated diseases------------>
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|valign="top" style="border:1px solid #66B3FF; background-color:transparent;"|
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<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">Top 10 [http://bigd.big.ac.cn/lncbook/disease lncRNA-associated diseases]</div>
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<div style="padding:0.5em 0.5em;">
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''Diseases and their associated lncRNAs' counts are listed below.''
 +
 
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* [http://bigd.big.ac.cn/lncbook/disease?filter=diseasemesh&term=Neoplasms Neoplasms]: 1,077
 +
 
 +
* [http://bigd.big.ac.cn/lncbook/disease?filter=diseasemesh&term=Digestive%20System%20Diseases Digestive System Diseases]: 427
 +
 
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* [http://bigd.big.ac.cn/lncbook/disease?filter=diseasemesh&term=Male%20Urogenital%20Diseases Male Urogenital Diseases]: 117
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* [http://bigd.big.ac.cn/lncbook/disease?filter=diseasemesh&term=Female%20Urogenital%20Diseases%20and%20Pregnancy%20Complications Female Urogenital Diseases and Pregnancy Complications]: 196
 +
 
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* [http://bigd.big.ac.cn/lncbook/disease?filter=diseasemesh&term=Respiratory%20Tract%20Diseases Respiratory Tract Diseases]: 224
 +
 
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* [http://bigd.big.ac.cn/lncbook/disease?filter=diseasemesh&term=Skin%20and%20Connective%20Tissue%20Diseases Skin and Connective Tissue Diseases]: 165
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* [http://bigd.big.ac.cn/lncbook/disease?filter=diseasemesh&term=Endocrine%20System%20Diseases Endocrine System Diseases]: 129
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* [http://bigd.big.ac.cn/lncbook/disease?filter=diseasemesh&term=Cardiovascular%20Diseases Cardiovascular Diseases]: 155
  
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213 Cancer 39 Nervous System Diseases
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* [http://bigd.big.ac.cn/lncbook/disease?filter=diseasemesh&term=Congenital,%20Hereditary,%20and%20Neonatal%20Diseases%20and%20Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities]: 150
  
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33 Congenital, Hereditary, and Neonatal Diseases 21 Musculoskeletal Diseases
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* [http://bigd.big.ac.cn/lncbook/disease?filter=diseasemesh&term=Nervous%20System%20Diseases Nervous System Diseases]: 103
  
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21 Hemic and Lymphatic Diseases 21 Mental Disorders
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</div>
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|}
  
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19 Cardiovascular Diseases 15 Nutritional and Metabolic Diseases
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<!--------------main part two---------------->
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{|border="0" cellspacing="0" cellpadding="0" style="margin:1em 0; background:transparent; width:100%;"
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|-
  
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15 Endocrine System Diseases 10 Skin and Connective Tissue Diseases
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<!-----------------Extensively curated---------------------->
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|valign="top" style="border:1px solid #66B3FF; background-color:transparent;width:50%;"|
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{|style="width:100%;"
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<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">Extensively curated</div>
  
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===<u>Top 10 Cancers</u>===
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|style="width:33%;|
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* [[NONHSAT028508|''HOTAIR'']]
  
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46 [[LncRNAWiki:gastric-cancer|Gastric Cancer]] 45 [[LncRNAWiki:breast-cancer|Breast Cancer]]
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* [[ENST00000534336.1|''MALAT-1'']]
  
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45 [[LncRNAWiki:lung-adenocarcinoma|Lung Cancer]] 34 [[LncRNAWiki:hepatocellular-carcinoma|Hepatocellular Carcinoma]]
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* [[NONHSAT017465|''H19'']]
  
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34 [[LncRNAWiki:prostate-cancer|Prostate Cancer]] 32 [[LncRNAWiki:colorectal-cancer|Colorectal Cancer]]
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* [[NONHSAT039745|''MEG3'']]
  
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23 [[LncRNAWiki:esophageal-carcinoma|Esophageal Carcinoma]] 15 [[LncRNAWiki:ovarian-cancer|Ovarian Cancer]]
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* [[ENST00000501122.2|''NEAT1'']]
  
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14 [[LncRNAWiki:bladder-cancer|Bladder Cancer]] 14 [[LncRNAWiki:glioma|Glioma]]
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* [[ENST00000513868.2|''PVT1'']]
  
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* [[NONHSAT007663|''GAS5'']]
  
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* [[Lnc-C9orf53-2:1|''CDKN2B-AS1'']]
  
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LncRNAWiki keeps frequent updates by community annotation of human lncRNAs and integration of newly identified lncRNAs with experimental evidence. In contrast to the previous version (released in 2014) that had 86 curated lncRNAs, the 2017 updated version has, a total of 948 lncRNAs that are community-curated ([[LncRNAWiki:Featured|Featured LncRNAs]]).
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* [[NONHSAT119717|''HOTTIP'']]
  
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Among these 948 featured lncRNAs, 404 have been experimentally proved to be associated with cancer and other diseases  ([[LncRNAWiki:Disease|Disease]]).
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* [[NONHSAT113149|''7SK'']]
  
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''Top diseases and top cancers, and the lncRNA numbers are listed.''
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|style="width:33%;|
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* [[BANCR|''BANCR'']]
  
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* [[BTG3-AS1|''BTG3-AS1'']]
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* [[CERNA2|''CERNA2'']]
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* [[FLICR|''FLICR'']]
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* [[GUARDIN|''GUARDIN'']]
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* [[LINC-ROR|''LINC-ROR'']]
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* [[PINCR|''PINCR'']]
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* [[PLUT|''PLUT'']]
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* [[LUNAR1|''LUNAR1'']]
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* [[Lnc-SRA1-1:1|''SRA'']]
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|style="width:34%;|
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* [[NONHSAT017524|''KCNQ1OT1'']]
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* [[NONHSAT076153|''PCGEM1'']]
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* [[NONHSAT137541|''XIST'']]
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* [[Lnc-EPCAM-1:2|''BCYRN1'']]
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* [[NONHSAT084827|''TUG1'']]
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* [[Lnc-OR10H5-1:1|''UCA1'']]
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* [[NONHSAT107640|''HULC'']]
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* [[NONHSAT129019|''PRNCR1'']]
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* [[TP53COR1|''TP53COR1'']]
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* [[Lnc-CDKN1A-1:1|''PANDAR'']]
 
|}
 
|}
  
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<!--------------main part two---------------->
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{|border="0" cellspacing="0" cellpadding="0" style="margin:1em 0; background:transparent; width:100%;"
 
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|-
 
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<!-----------------Classification---------------------->
 
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|valign="top" style="border:1px solid #66B3FF; background-color:transparent;width:55%;"|
 
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<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">Classification</div>
 
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<div style="padding:0.5em 0.5em;">[[File:web2a.png|left|410px]]
 
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The majority of the lncRNA information was initially seeded with a subset of information from [http://www.gencodegenes.org/ GENCODE], [http://www.bioinfo.org/noncode/ NONCODE], [http://www.lncipedia.org/ LNCipedia], and [http://www.lncrnadb.org/ lncRNAdb], and we classified these lncRNAs into seven groups based on their genomic location in respect to protein-coding genes (Ma etal. 2013, RNA Biology). [[Help:Contents#Database content|''Help'']]
 
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<br /></div>
 
  
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<!-----------------Function---------------------->
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|valign="top" style="border:1px solid #66B3FF; background-color:transparent;"|
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<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">[http://bigd.big.ac.cn/lncbook/function Function]</div>
  
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<!-----------------Small proteins---------------------->
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<div style="padding:0.5em 0.5em;">
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|valign="top" style="border:1px solid #66B3FF; background-color:transparent;45%;"|
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''Functional mechanisms and their associated lncRNAs' counts are listed below.''
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<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">Small proteins</div>
 
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<div style="padding:0.5em 0.5em;">[[File:SmallPRO-1.png|left|330px]]
 
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We developed computational approaches for identification of small proteins in all the human lncRNAs in LncRNAWiki.  
 
  
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As a result, we identified '''9,387''' lncRNAs potentially encoding small proteins and '''2,246''' among them are with high confidence ([[LncRNAWiki:small proteins|lncRNAs and small proteins]], [[Help:Contents#Database content|Help]]).  
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* [http://bigd.big.ac.cn/lncbook/function?filter=functionmec&term=transcriptional%20regulation Transcriptional regulation]: 282
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<br /></div>
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* [http://bigd.big.ac.cn/lncbook/function?filter=functionmec&term=ceRNA ceRNA]: 73
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* [http://bigd.big.ac.cn/lncbook/function?filter=functionmec&term=translational%20control Translational control]: 13
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* [http://bigd.big.ac.cn/lncbook/function?filter=functionmec&term=protein%20localization Protein localization]: 6
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* [http://bigd.big.ac.cn/lncbook/function?filter=functionmec&term=splicing%20regulation Splicing regulation]: 4
  
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</div>
 
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<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">How to Cite</div>
 
<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">How to Cite</div>
 
<div style="padding:0.5em 1em;">
 
<div style="padding:0.5em 1em;">
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If you use any data or information in your work, please cite the following primary publication:
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If you use any data or information in your work, please cite the following publications.
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* Lina Ma, Ang Li, Dong Zou, Xingjian Xu, Lin Xia, Jun Yu, Vladimir B. Bajic and Zhang Zhang. [http://nar.oxfordjournals.org/content/early/2014/11/15/nar.gku1167.full '''LncRNAWiki: harnessing community knowledge in collaborative curation of human long non-coding RNAs'''.] (2015) ''Nucleic Acids Research'', 43:D187-92.
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Primary publication:
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* [http://nar.oxfordjournals.org/content/early/2014/11/15/nar.gku1167.full '''LncRNAWiki: harnessing community knowledge in collaborative curation of human long non-coding RNAs'''.] (2015) ''Nucleic Acids Research'', 43:D187-92.
  
 
Related publication:
 
Related publication:
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* BIG Data Center Members: [http://nar.oxfordjournals.org/content/early/2016/11/28/nar.gkw1060.full '''The BIG Data Center: from deposition to integration to translation'''.] ''Nucleic Acids Research'' 2017, accepted and in press.
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* [https://currentprotocols.onlinelibrary.wiley.com/doi/abs/10.1002/cpbi.82 '''Community Curation and Expert Curation of Human Long Noncoding RNAs with LncRNAWiki and LncBook'''.] '' Curr Protoc Bioinformatics 2019''.
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* Lina Ma, Vladimir B. Bajic, Zhang Zhang. [https://www.landesbioscience.com/journals/rnabiology/article/24604/?nocache=227993923 '''On the classification of long non-coding RNAs'''.] (2013) ''RNA Biology'', 10(6),924-933.
 
 
</div>
 
</div>
  

Revision as of 08:01, 16 September 2019



Welcome to LncRNAWiki
106,063 human long non-coding RNAs inside
Introduction

LncRNAWiki is a wiki-based, publicly editable and open-content platform for community curation of human long non-coding RNAs (lncRNAs), viz., a community-curated lncRNA knowledgebase. Unlike conventional biological databases based on expert curation, lncRNAWiki harnesses collective intelligence to collect, edit and annotate information about lncRNAs, quantifies users' contributions in each annotated lncRNA and provides explicit authorship to encourage more participation from the whole scientific community.

LncRNAWiki, an important component of LncBook, provides community annotations of human lncRNAs
Featured-2019-3.png
Extensively curated

Functional mechanisms and their associated lncRNAs' counts are listed below.

How to Cite

If you use any data or information in your work, please cite the following publications.

Primary publication:

Related publication:

Visitor Statistics

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