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|style="width:50%; text-align:center; white-space:nowrap; color:#000"|
 
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<div style="font-size:180%; border:none; margin:0; padding:.5em; color:#000;">Welcome to LncRNAWiki</div>
 
<div style="font-size:180%; border:none; margin:0; padding:.5em; color:#000;">Welcome to LncRNAWiki</div>
<div style="padding:0em; font-size:100%">[[:Category:Transcripts|105,824]] human long non-coding RNAs inside</div>
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<div style="padding:0em; font-size:100%">[[:Category:Transcripts|106,063]] human long non-coding RNAs inside</div>
  
 
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*[[File:New5.png]][[LncRNAWiki:Featured|Featured LncRNAs]]
 
*[[File:New5.png]][[LncRNAWiki:Featured|Featured LncRNAs]]
 
*[[File:New5.png]][[LncRNAWiki:Small_proteins|Small Proteins]]
 
*[[File:New5.png]][[LncRNAWiki:Small_proteins|Small Proteins]]
*[[File:New5.png]][[LncRNAWiki:Disease|Disease]]
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*[[File:New5.png]][[LncRNAWiki:Disease|Diseases]]
 
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<div style="padding:0.2em 0.5em;text-align:center;font-weight:bold;color:#2d2d2d;">''Imagine a world in which every single person on the planet has free access to the sum of all human knowledge. — Jimmy Wales, Founder of Wikipedia''</div>
 
<div style="padding:0.2em 0.5em;text-align:center;font-weight:bold;color:#2d2d2d;">''Imagine a world in which every single person on the planet has free access to the sum of all human knowledge. — Jimmy Wales, Founder of Wikipedia''</div>
 
</div>
 
</div>
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<!--------------main part one---------------->
 
<!--------------main part one---------------->
 
{|border="0" cellspacing="0" cellpadding="0" style="margin:1em 0; background:transparent; width:100%;"
 
{|border="0" cellspacing="0" cellpadding="0" style="margin:1em 0; background:transparent; width:100%;"
 
|-
 
|-
<!-----------Disease------------>
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<!-----------Top 10 lncRNA-associated diseases------------>
|valign="top" style="border:1px solid #66B3FF; background-color:transparent; "|
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|valign="top" style="border:1px solid #66B3FF; background-color:transparent;width:45%;"|
<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">Disease</div>
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<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">Top 10  [[LncRNAWiki:Disease|lncRNA-associated diseases]]</div>
<div style="padding:0.5em 0.5em;">[[File:Wordcloud1.png|left|850px]]  
 
===<u>Top 10 Diseases</u>===
 
  
213 Neoplasms
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<div style="padding:0.5em 0.5em;">
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''Diseases and their associated lncRNAs' counts are listed below.''
  
39 Nervous System Diseases
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* [[LncRNAWiki:Cancer|Cancer]]: 212
  
33 Congenital, Hereditary, and Neonatal Diseases
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* [[LncRNAWiki:Nervous System Diseases|Nervous System Diseases]]: 37
  
21 Musculoskeletal Diseases
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* [[LncRNAWiki:Cardiovascular Diseases|Cardiovascular Diseases]]: 22
  
21 Hemic and Lymphatic Diseases
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* [[LncRNAWiki:Congenital, Hereditary, and Neonatal Diseases and Abnormalities|Congenital, Hereditary, and Neonatal Diseases and Abnormalities]]: 21
  
21 Mental Disorders
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* [[LncRNAWiki:Musculoskeletal Diseases|Musculoskeletal Diseases]]: 20
  
19 Cardiovascular Diseases
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* [[LncRNAWiki:Hemic and Lymphatic Diseases|Hemic and Lymphatic Diseases]]: 19
  
15 Nutritional and Metabolic Diseases
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* [[LncRNAWiki:Endocrine System Diseases|Endocrine System Diseases]]: 18
  
15 Endocrine System Diseases
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* [[LncRNAWiki:Mental Disorders|Mental Disorders]]: 14
  
10 Skin and Connective Tissue Diseases
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* [[LncRNAWiki:Skin and Connective Tissue Diseases|Skin and Connective Tissue Diseases]]: 9
  
===<u>Top 10 Cancers</u>===
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* [[LncRNAWiki:Nutritional and Metabolic Diseases|Nutritional and Metabolic Diseases]]: 9
  
46 Gastric Cancer
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</div>
  
45 [[LncRNAWiki:breast-cancer|Breast Cancer]]
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|style="padding:0px 4px;"|
  
45 [[LncRNAWiki:lung-adenocarcinoma|Lung Cancer]]
 
  
34 [[LncRNAWiki:hepatocellular-carcinoma|Hepatocellular Carcinoma]]
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<!-----------Featured lncRNAs------------>
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|valign="top" style="border:1px solid #66B3FF; background-color:transparent;width:54.5%;"|
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<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">[[LncRNAWiki:Featured|Featured lncRNAs]]</div>
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<div style="padding:0.5em 0.5em;">
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<table>
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<tr>
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<td>[[File:Featured4.png|left|430px|link=LncRNAWiki:Featured]]</td>
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<td valign="top">
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Extensively curated:
  
34 [[LncRNAWiki:prostate-cancer|Prostate Cancer]]
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* [[ABALON|''ABALON'']]
  
32 [[LncRNAWiki:colorectal-cancer|Colorectal Cancer]]
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* [[BANCR|''BANCR'']]
  
23 [[LncRNAWiki:esophageal-carcinoma|Esophageal Carcinoma]]
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* [[BTG3-AS1|''BTG3-AS1'']]
  
15 [[LncRNAWiki:ovarian-cancer|Ovarian Cancer]]
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* [[CERNA2|''CERNA2'']]
  
14 [[LncRNAWiki:bladder-cancer|Bladder Cancer]]
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* [[JADRR|''JADRR'']]
  
14 [[LncRNAWiki:glioma|Glioma]]
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* [[LINC-ROR|''LINC-ROR'']]
  
Among these 948 featured lncRNAs, 404 have been experimentally proved to be associated with cancer and other diseases  ([[LncRNAWiki:Disease|Disease]]).
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* [[PINCR|''PINCR'']]
  
''Top diseases and top cancers, and the lncRNA numbers are listed.''
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* [[LUNAR1|''LUNAR1'']]
  
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* [[ENST00000534336.1|''MALAT-1'']]
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* [[NONHSAT137541|''Xist'']]
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</td>
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</tr>
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</table>
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</div>
 
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{|border="0" cellspacing="0" cellpadding="0" style="margin:1em 0; background:transparent; width:100%;"
 
{|border="0" cellspacing="0" cellpadding="0" style="margin:1em 0; background:transparent; width:100%;"
 
|-
 
|-
<!-----------------Classification---------------------->
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<!-----------------Small proteins---------------------->
|valign="top" style="border:1px solid #66B3FF; background-color:transparent;width:35%;"|
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|valign="top" style="border:1px solid #66B3FF; background-color:transparent;45%;"|
<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">Classification</div>
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<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">[[LncRNAWiki:Small_proteins|Small proteins]]</div>
<div style="padding:0.5em 0.5em;">[[File:web2a.png|center|410px]]
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<div style="padding:0.5em 0.5em;">[[File:SmallPRO-5.png|center|220px|link=LncRNAWiki:Small_proteins]]</div>
The majority of the lncRNA information was initially seeded with a subset of information from [http://www.gencodegenes.org/ GENCODE], [http://www.bioinfo.org/noncode/ NONCODE], [http://www.lncipedia.org/ LNCipedia], and [http://www.lncrnadb.org/ lncRNAdb], and we classified these lncRNAs into seven groups based on their genomic location in respect to protein-coding genes (Ma etal. 2013, RNA Biology). [[Help:Contents#Database content|''Help'']]
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* [[LncRNAWiki:Small_proteins|'''9,387''']] lncRNAs potentially encoding small proteins
<br /></div>
 
  
<!-----------Featured lncRNA------------>
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* '''2,246''' small proteins identified with high confidence, by considering protein instability, secondary structure and transmembrane helix
|valign="top" style="border:1px solid #66B3FF; background-color:transparent;width:35%;"|
 
<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">Featured lncRNA</div>
 
<div style="padding:0.5em 0.5em;">[[File:Featured2.png|center|390px|caption]]
 
LncRNAWiki keeps frequent updates by community annotation of human lncRNAs and integration of newly identified lncRNAs with experimental evidence.
 
  
In contrast to the previous version (released in 2014) that had 86 curated lncRNAs, the 2017 updated version has, a total of 948 lncRNAs that are community-curated ([[LncRNAWiki:Featured|Featured LncRNAs]]).
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|style="padding:0px 4px;"|
<br /></div>
 
  
<!-----------------Small protein---------------------->
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<!-----------------Classification---------------------->
|valign="top" style="border:1px solid #66B3FF; background-color:transparent;30%;"|
 
<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">Small protein</div>
 
<div style="padding:0.5em 0.5em;">[[File:SmallPRO-1.png|center|330px]]
 
We developed computational approaches for identification of small proteins in all the human lncRNAs in LncRNAWiki.
 
 
 
As a result, we identified '''9,387''' lncRNAs potentially encoding small proteins and '''2,246''' among them are with high confidence ([[LncRNAWiki:small proteins|lncRNAs and small proteins]], [[Help:Contents#Database content|Help]]).
 
<br /></div>
 
  
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|valign="top" style="border:1px solid #66B3FF; background-color:transparent;width:54.5%;"|
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<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">[[LncRNAWiki:Classification|Classification]]</div>
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<div style="padding:0.5em 0.5em;">[[File:Classification.png|center|400px|link=LncRNAWiki:Classification]]</div>
 
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<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">How to Cite</div>
 
<div style="background:#ACD6FF; border-bottom:1px solid #66B3FF; padding:0.2em 0.5em; font-size:125%; font-weight:bold;">How to Cite</div>
 
<div style="padding:0.5em 1em;">
 
<div style="padding:0.5em 1em;">
If you use any data or information in your work, please cite the following primary publication:
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If you use any data or information in your work, please cite the following publications.
* Lina Ma, Ang Li, Dong Zou, Xingjian Xu, Lin Xia, Jun Yu, Vladimir B. Bajic and Zhang Zhang. [http://nar.oxfordjournals.org/content/early/2014/11/15/nar.gku1167.full '''LncRNAWiki: harnessing community knowledge in collaborative curation of human long non-coding RNAs'''.] (2015) ''Nucleic Acids Research'', 43:D187-92.
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 +
Primary publication:
 +
* [http://nar.oxfordjournals.org/content/early/2014/11/15/nar.gku1167.full '''LncRNAWiki: harnessing community knowledge in collaborative curation of human long non-coding RNAs'''.] (2015) ''Nucleic Acids Research'', 43:D187-92.
  
Related publication:
+
Related publications:
* BIG Data Center Members: [http://nar.oxfordjournals.org/content/early/2016/11/28/nar.gkw1060.full '''The BIG Data Center: from deposition to integration to translation'''.] ''Nucleic Acids Research'' 2017, accepted and in press.
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* [http://nar.oxfordjournals.org/content/early/2016/11/28/nar.gkw1060.full '''The BIG Data Center: from deposition to integration to translation'''.] (2017) ''Nucleic Acids Research'', 45:D18-24.
* Lina Ma, Vladimir B. Bajic, Zhang Zhang. [https://www.landesbioscience.com/journals/rnabiology/article/24604/?nocache=227993923 '''On the classification of long non-coding RNAs'''.] (2013) ''RNA Biology'', 10(6),924-933.
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* [https://www.landesbioscience.com/journals/rnabiology/article/24604/?nocache=227993923 '''On the classification of long non-coding RNAs'''.] (2013) ''RNA Biology'', 10:924-933.
 
</div>
 
</div>
  

Revision as of 09:08, 1 August 2017


Welcome to LncRNAWiki
106,063 human long non-coding RNAs inside
Introduction

LncRNAWiki is a wiki-based, publicly editable and open-content platform for community curation of human long non-coding RNAs (lncRNAs), viz., a community-curated lncRNA knowledgebase. Unlike conventional biological databases based on expert curation, lncRNAWiki harnesses collective intelligence to collect, edit and annotate information about lncRNAs, quantifies users' contributions in each annotated lncRNA and provides explicit authorship to encourage more participation from the whole scientific community.

Imagine a world in which every single person on the planet has free access to the sum of all human knowledge. — Jimmy Wales, Founder of Wikipedia


SmallPRO-5.png
  • 9,387 lncRNAs potentially encoding small proteins
  • 2,246 small proteins identified with high confidence, by considering protein instability, secondary structure and transmembrane helix


Classification.png
How to Cite

If you use any data or information in your work, please cite the following publications.

Primary publication:

Related publications:

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