Difference between revisions of "MUC5B-AS1"

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Latest revision as of 06:23, 26 December 2018

MUC5B-AS1, MUC5B antisense RNA 1, a novel long non-coding antisense transcript for MUC5B.

Annotated Information

Name

MUC5B-AS1: MUC5B antisense RNA 1 (HGNC:53936)

Characteristics

A single-strand antisense lncRNA that is transcribed from the negative strand of the MUC5B locus. MUC5B-AS1 is located at chromosomal 11p15.5, and composed of two exons with a full length of 434 nt. The sequence of MUC5B-AS1 was analyzed and three potential ORFs that might code peptides of 33–118 amino acids were identified. In order to confirm the non-coding nature of MUC5B-AS1, coding-potential analysis was performed by Coding Potential Assessment Tool (CPAT)23 and Coding Potential Calculator (CPC) computational algorithm, which predicted that MUC5B-AS1 had a very low coding potential. RNA fluorescence in situ hybridization (FISH) assay to examine the subcellular localization of MUC5B-AS1 revealed that MUC5B-AS1 was localized both in the nucleus and cytoplasm and predominantly in the cell cytoplasm. [1]

Function

MUC5B-AS1 promotes cell migration and invasion by forming an RNA-RNA duplex with MUC5B, thereby increasing MUC5B expression levels in lung adenocarcinoma.[1]

Regulation

MUC5B-AS1 and MUC5B are co-expressed and mutually regulate each other. [1]

Expression

MUC5B-AS1 was upregulated in lung adenocarcinoma tissues compared with normal lung tissues. The high expression of MUC5B was significantly associated with poor outcomes in lung adenocarcinoma.[1]

Disease

Lung adenocarcinoma [1]

Labs working on this lncRNA

  • Department of Epidemiology, College of Preventive Medicine, Army Medical University (Third Military Medical University), 400038 Chongqing, China
  • Department of Pathology, Southwest Hospital, Army Medical University (Third Military Medical University), 400038 Chongqing, China
  • Department of Thoracic Surgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), 400038 Chongqing, China
  • Department of Respiratory Disease, Xinqiao Hospital, Army Medical University (Third Military Medical University), 400038 Chongqing, China

References

  1. 1.0 1.1 1.2 1.3 1.4 Yuan S, Liu Q, Hu Z, Zhou Z, Wang G, Li C et al. Long non-coding RNA MUC5B-AS1 promotes metastasis through mutually regulating MUC5B expression in lung adenocarcinoma[J]. Cell death & disease. 2018, 9(5):450-450.

Sequence

>gi|112577518|ref|NR_157183.1| Homo sapiens MUC5B antisense RNA 1 (MUC5B-AS1), long non-coding RNA

000001 TGGATCCAGT GGATGCAGTC GTAGTGGCTG TTGTGGTCAG CTCTGTGAGG ATCCAGTGGA CGCAGTCGTA GTGGCTGTTG 000080
000081 TGGTCGGCTT TGTGAGGATC CAGGTCGTCC CCGGAGTTGA GGAGGGCGTG GCCGTGGAGC TGGTGGCTGG GGTACTGGGG 000160
000161 CAGTGGCTGT AGTCGTCACA GCAAAGCACA CGCACGTTGT AGTTGAAGCA CATGTTGAAC CTGCCTGTCT GGTCTTCGTT 000240
000241 CTTGCAGGTC AGCCCCGTCT CCAGGCTGCA GGTCAGCACC TGCCCGACCT GGTCGATGCT TACCTCGGGG TAGTTCTCCG 000320
000321 CCCGGCACTC TATGCTCTTT GGTGCCCAGC ACATCTTGCC CCCAGCAGCC CTGATGTTTT CAAAAGTTTC CATGTCCCCG 000400
000401 CCTGCAACCC CTGAGGTTGG GAAGTCCACG TCAA