MAPK6-DT, a divergent lncRNA (long noncoding RNA) of MAPK6 overexpressed in liver tumorigenesis.
MAPK6-DT: MAPK6 divergent transcript (HGNC:53900)
MAPK6-DT is a divergent lncRNA (long noncoding RNA) of MAPK6 with chromosomal location at 15q21.2. Divergent lncRNAs, often modulate their nearby genes in cis, are positively-related to their nearby genes. As a divergent lncRNA of MAPK6, lncMAPK6 is co-expressed with MAPK6 in liver tumor and TICs.
LncMAPK6 regulates the expression of MAPK6 through transcriptional activation. LncMAPK6 promotes liver tumor propagation and TIC self-renewal through MAPK6. LncMAPK6 interacts with and recruits RNA polymerase II to MAPK6 promoter, and finally activates the transcription of MAPK6. Through MAPK6 transcriptional regulation, lncMAPK6 drives MARK signaling activation.
MAPK6 is critical for the function of lncMAPK6 as after MAPK6 knockout, lncMAPK6 had no effect on liver TIC self-renewal. LncMAPK6 had no effect on tumor invasion if MAPK6 was knockout, further confirming the importance of MAPK6 in lncMAPK6 signaling
lncMAPK6 overexpression through CRISPRa strategy promoted the self-renewal of liver TICs.
Liver cancer 
Labs working on this lncRNA
- Department of general surgery, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangdong Sheng, China
- Department of Abdominal Oncology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangdong Sheng, China
- Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Sheng, China
- Huang G, Jiang H, He Y, Lin Y, Xia W, Luo Y et al. LncMAPK6 drives MAPK6 expression and liver TIC self-renewal[J]. Journal of experimental & clinical cancer research : CR. 2018, 37(1):105-105.
>gi|112543478|ref|NR_156732.1| Homo sapiens MAPK6 divergent transcript (MAPK6-DT), long non-coding RNA