Lnc-LRR1-1:1

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Revision as of 07:51, 8 October 2014 by 192.168.72.12 (talk) (Function)
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Annotated Information

Name

7SL

Characteristics

~300 nt, transcribed by RNAPIII.

The eukaryotic small cytoplasmic 7SL is an RNA component of the SRP (signal recognition particle), which associates with the ribosome and targets nascent proteins to the endoplasmic reticulum for secretion or membrane insertion ((Walter 1982)) ((Zwieb 2004)).

Function

7SL RNA is required for structural and functional properties of SRP ((Walter 1982)), being a scaffold component upon which the six proteins of the SRP bind in higher eukaryotes. In mammals SRP consists of the SRP RNA the six proteins named SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72 ((Walter 1983)).

Bacterial SRP has a much reduced complexity, consisting of a small SRP RNA (4.5S RNA) and a homolog of protein SRP54, also called Ffh or P48 ((Bernstein 1993)). In archaea only two SRP proteins, SRP19 and SRP54, are thought to be part of the SRP, although SRP RNA closely resembles the mammalian homolog ((Bhuiyan 2000)).

There is evidence that a highly conserved region of 7SL RNA catalyses the binding of SRP to its receptor SR, and that this RNA stimulates the GTPase activities of the SRP-SR complex ((Zhang 2008)) ((Siu 2006)) ((Peluso 2000)).

Expression

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Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

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Basic Information

Transcript ID

lnc-LRR1-1:1

Source

LNCipedia2.1

Same with

,

Classification

intergenic

Length

299 nt

Genomic location

chr14+:50053297..50053596

Exon number

1

Exons

50053297..50053596

Genome context

Sequence
000001 GCCGGGCGCG GTGGCGCGTG CCTGTAGTCC CAGCTACTCG GGAGGCTGAG GCTGGAGGAT CGCTTGAGTC CAGGAGTTCT 000080
000081 GGGCTGTAGT GCGCTATGCC GATCGGGTGT CCGCACTAAG TTCGGCATCA ATATGGTGAC CTCCCGGGAG CGGGGGACCA 000160
000161 CCAGGTTGCC TAAGGAGGGG TGAACCGGCC CAGGTCGGAA ACGGAGCAGG TCAAAACTCC CGTGCTGATC AGTAGTGGGA 000240
000241 TCGCGCCTGT GAATAGCCAC TGCACTCCAG CCTGGGCAAC ATAGCGAGAC CCCGTCTCT
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Annotation (From lncRNAdb)

[lnc-LRR1-1:1]
Section Description
ID 7SL
Characteristics ~300 nt, transcribed by RNAPIII. The eukaryotic small cytoplasmic 7SL is an RNA component of the SRP (signal recognition particle), which associates with the ribosome and targets nascent proteins to the endoplasmic reticulum for secretion or membrane insertion (Walter (1982)) (Zwieb (2005)).
Expression Ubiquitously expressed at high levels. Localises to the cytoplasm. An expression profile from 11 human tissues using RNA sequencing showed 7SL was most highly expressed ncRNA and could be an order of magnitude more highly expressed than any mRNA (Castle (2010)).
Function 7SL RNA is required for structural and functional properties of SRP (Walter (1982)), being a scaffold component upon which the six proteins of the SRP bind in higher eukaryotes. In mammals SRP consists of the SRP RNA the six proteins named SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72 (Walter (1983)). Bacterial SRP has a much reduced complexity, consisting of a small SRP RNA (4.5S RNA) and a homolog of protein SRP54, also called Ffh or P48 (Bernstein (1993)). In archaea only two SRP proteins, SRP19 and SRP54, are thought to be part of the SRP, although SRP RNA closely resembles the mammalian homolog (Bhuiyan (2000)). There is evidence that a highly conserved region of 7SL RNA catalyses the binding of SRP to its receptor SR, and that this RNA stimulates the GTPase activities of the SRP-SR complex (Zhang (2008)) (Siu (2007)) (Peluso (2000)).
Conservation May have originated from the bacterial SRP (GTP-regulated ribonucleoprotein that targets secretory or membrane proteins during translation), it is ubiquitously present in eukaryotic cells and several viruses (Li (1982)). The secondary structure of 7SL RNA is conserved from prokaryotes to distant eukaryotic species (Labuda (1994)).
Misc 7SL is the RNA ancestor of Alu transposon sequences, which emerged ~ 55 million years ago, are present specifically in primates and comprise ~10% of the human genome. Rodent B1 elements, as well as 4.5S and primate BC200 RNAs are also related to the terminal portions of 7SL RNA sequence (Labuda (1994)) (Quentin (1994)).
Name RN7SL1: RNA, 7SL, cytoplasmic 1

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