Difference between revisions of "Lnc-FANK1-3:1"
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sequence = <dnaseq>TCCACGCTGTGAAATGTAACCTCCTGTGTGTATTTCCACAATGGAGAATGTTAGGCTTCGTTTCC</dnaseq>| | sequence = <dnaseq>TCCACGCTGTGAAATGTAACCTCCTGTGTGTATTTCCACAATGGAGAATGTTAGGCTTCGTTTCC</dnaseq>| | ||
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− | [[Category:Antisense]][[Category:lnc-FANK1-3]] | + | [[Category:Antisense]][[Category:lnc-FANK1-3]][[Category:Transcripts]] |
Revision as of 04:14, 17 October 2014
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Contents
Annotated Information
Name
CAR10: Chromatin Associated RNA 10
Characteristics
Positioned between 3' ends of of FANK1 (fibronectin) and ADAM12 (ADAM metallopeptidase domain 12) genes, with an overlap of a few hundred base pairs with ADAM12.
Function
Positively regulates gene expression of FANK1 and ADAM12 neighboring genes through modulating the chromatin structure in cis, as siRNA knock-down of the Intergenic10 ncRNA results in reduced expression of both FANK1 and ADAM12 mRNAs, with a significant decrease in the level of active chromatin mark H3K4me2 on FANK1 and ADAM12 promoters
Knock-down of the ncRNA had no effect on the expression of two tested distal genes, UROS and DOCK1.
Note: Despite its overlap with the 3' end of ADAM12, Intergenic 10 is not simply an Adam12 3'UTR, as siRNA knockdown of Adam12 failed to decrease FANK1 expression unlike knockdown of CAR Intergenic 10.
Expression
CAR Intergenic 10, ADAM12 and FANK1 are co-expressed in different tissues, including placenta, brain and a human skin fibroblast (HF) cell line.
CAR Intergenic 10 was most highly expressed in HF cells and very lowly expressed in brain, with placenta in-between.
Conservation
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Misc
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Transcriptomic Nomeclature
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Regulation
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Allelic Information and Variation
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Evolution
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Labs working on this lncRNA
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References
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Basic Information
Transcript ID |
lnc-FANK1-3:1 |
Source |
LNCipedia2.1 |
Same with |
, |
Classification |
antisense |
Length |
65 nt |
Genomic location |
chr10+:127703096..127703161 |
Exon number |
1 |
Exons |
127703096..127703161 |
Genome context |
|
Sequence |
000001 TCCACGCTGT GAAATGTAAC CTCCTGTGTG TATTTCCACA ATGGAGAATG TTAGGCTTCG TTTCC
|