Difference between revisions of "Lnc-CDKN1A-1:1"

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==Annotated Information==
 
==Annotated Information==
 
===Name===
 
===Name===
 +
PANDAR:promoter of CDKN1A antisense DNA damage activated RNA
 +
 
PANDA
 
PANDA
  

Revision as of 08:56, 28 June 2016

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Annotated Information

Name

PANDAR:promoter of CDKN1A antisense DNA damage activated RNA

PANDA

Characteristics

Bidirectional transcript from the CDKN1A promoter.

1.5kb single exon.

Sequence runs antisense through a processed LAP3 pseudogene and contains a SINE.

Function

P53 effector gene, acts in response to DNA damage to limit apoptosis while CDKN1A induces cell cycle arrest.

Loss of PANDA leads to the apoptosis of doxorubicin treated cells.

Loss of PANDA affected the expression of many genes during the DNA damage response. Upregulated genes were enriched for those involved in apoptosis, including the apoptotic activators APAF1, BIK, FAS and LRDD. Leading to apoptosis of doxorubicin treated cells.

Cell death genes downstream of p53 are known to have NF-YA binding sites. PANDA RNA interacts with the transcription factor NF-YA and attenuates its occupany of target gene promoters.

Expression

One of five lncRNAs surrounding the transcription start site of the cell cycle gene CDKN1A that, along with the CDKN1A protein coding gene, were induced in human fetal lung fibroblasts upon DNA damage by doxorubicin.

Induced up to 40 fold upon DNA damage peaking 16 h after doxorubicin treatment, a much greater response than shown by CDKN1A.

Expression of PANDA and CDKN1A were positively regulated by p53. CDKN1A did not induce PANDA.

Conservation

Syntenic sequence appear to be present in apes and old world monkeys (the Catarrhini).

Misc

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Transcriptomic Nomeclature

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Regulation

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

Annotation originally sourced from lncRNAdb.

Basic Information

Transcript ID

lnc-CDKN1A-1:1

Source

LNCipedia2.1

Same with

,

Classification

intergenic

Length

1506 nt

Genomic location

chr6+:36641397..36642903

Exon number

,

Exons

,

Genome context

Sequence
000001 ACGAATTCTT TCAGGAATGC CGCAGATGTA CATGCTCCCG CAGATCTATA TTTTCCAATG TTGTTAACAT CAGCCAGCTG 000080
000081 GCAATCTACA ACCTGTCTTG TACAATGTTT GAAGAGAGGC ATCCTCCAGA CACGGTCCCC TGTTTCAATG CTGGCCTCGA 000160
000161 AGAGCTTGTT CCAGAGCCAG GATGAATTGG TAAAGACCCC AGTGGCACCT GACCCCAAAG CTACATCTAT GACACCTGTT 000240
000241 AAGGTGGTGG CATTGAGGAT GACCTTCGGG TTAAATGTGT GCACGTAACA GAGCGCATCA GCCAGTATGA GCCTCCCCTC 000320
000321 AGCATCAGTG TTACCAACCT GGATGGTCTT CCTGTTCCTG GCTCTAACAA CATCCCCCAG CTTGTTGGCC TTGCCGCTGG 000400
000401 GCATGTTTTC ACAGAGGGGC CAGACCTATA ATATTAATGG GCAAACTGAG ATTTGCAGCA GACACAATGG CTGAGCATAT 000480
000481 AGTTGTAGCT CCTCCCATGT CGGCCCTCAT GAGGTCCATA TTTGCAGAAG CCTTGATGGA GATACCACCA CTGTCAAAGG 000560
000561 TAATTCCTTT CCCAACAAAC AAGGGGTGGT TTGTCTGCAT TGGGGCTGCC TATGTAGTGA ATTTCCAAGA AGACTGAGGG 000640
000641 CTCGTCAGAT CCTTTGGCCA CACTGAGGAA TGATCCCATT GCCTGTTCCT CAATCCAAGA CCTGGGTCTG ATATGAAACT 000720
000721 CGGTTTACTA CTAGCGCTTT TGAGATTCTT CTCAATAATT TCGGCAAATC TGGTTGGCAT CATCTCGCTG GCTGGCGTCT 000800
000801 CCATCATGCC AAGTTCTGCC CAGAAGCAAA CAGGACTCCT TTCTGCCAGG CCTCCTGATC CCCAGTTCCA TAGAGCTTCA 000880
000881 CCGACATAGC CATCTTCTTT TTTTGCTTTA GGTCATCGTA TTCATAGAGA CCAAGCACCG CGCCCTCCTC AGCAGCCTGA 000960
000961 GCATCTCTAC AGGGATCCAC CTCCACGGAA GAGAGCTCCA GGTCTTGAAT CTGCCTGCAT CCTGCTGCAA CAGCAGCTCT 001040
001041 GATGTTTTCT TTGCCTTCCT GCCAGTTTTC CTGTTCGTCG ATTCTGGCTG CCTTTTTGCC GAGGCCAACT AGCACCACGC 001120
001121 TGGGGAAGTC CTGATGCAGA CCATAAAAGT TTCGAGTCTT GCCTGCCTTC AGAGGTGGTC CAGATATGTT CAAAGTCTCT 001200
001201 CTCAGCTTTC CAGCTATCAA TTTATCAAGA TTCTCTCCTG CACTTGTGAA CTGTGGCACA TCATCTTCTT TTTCTTTGGA 001280
001281 ATAGATTCCT AAAACAAGGC CCTTCGTCAT GTCTGCAGCG GAGAGACCCC GGCTCCCGAA ACATCTCACG GCCAGACGTC 001360
001361 AGACGATGAC TCGCCCCACC CAATGTTTGT ATTTTAGTAG AGAGAGGGTT TCTCTATGTT GGTCAGGCTG GTCTCAAACC 001440
001441 TCGACCTCAG TTGATCTGTC TGCCTCGGTC TCCCAAAGTG CTGAGATTAC AGGCGTGAGC CACTGC
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