Difference between revisions of "LNCOC1"

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Latest revision as of 10:44, 26 December 2018

LNCOC1, a long non-protein coding gene acts as a key regulator in the development and progression of ovarian cancer (OC).

Annotated Information

Name

LNCOC1: lncRNA associated with ovarian cancer 1 (HGNC:53947)

Alias

Lnc-OC1 [1]

Characteristics

Lnc-OC1 is located at the chromosome 8 (GRCh38.p7, 142702252–142726973). RNA-fluorescence in situ hybridization (RNA-FISH) results revealed that Lnc-OC1 was distributed both in the nucleus and in the cytoplasm of HEY-T30 cells.[1]

Function

Lnc-OC1 functions as an oncogene in OC. Lnc-OC1 can induce the OC cell proliferation by promoting cell cycle progression and suppressing cellular apoptosis. Lnc-OC1 represses the expression of endogenous miR-34a and miR-34c as a sponge. It promotes xenograft growth via sponging miR-34a and miR-34c. [1]

Regulation

Ectopic expression of miR-34a or miR-34c significantly decreased the expression level of Lnc-OC1 and vice versa. [1]

Expression

Lnc-OC1 was significantly upregulated in OC tissues and Kaplan-Meier survival analysis confirmed that high Lnc-OC1 expression was associated with poor prognosis of OC patients. Importantly, it was also demonstrated that knockdown of Lnc-OC1 suppressed cell proliferation, colony formation, invasion and migration in vitro and inhibited tumorigenicity in vivo. [1]

Disease

Ovarian cancer [1]

Labs working on this lncRNA

  • Department of Immunology and Microbiology, Basic Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
  • Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China; Department of Biochemistry and Biophysics, Texas A&M University and Texas AgriLife Research, College Station, TX 77843-2128, USA.
  • North China University of Science and Technology, Tangshan 063210, China.
  • State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China.

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Tao F, Tian X, Lu M & Zhang Z. A novel lncRNA, Lnc-OC1, promotes ovarian cancer cell proliferation and migration by sponging miR-34a and miR-34c[J]. Journal of genetics and genomics. 2018, 45(3):137-145.

Sequence

>ENST00000520572.1, Homo sapiens lncRNA LNCOC1 cDNA

000001 GAAGACGCGG CCTGGCCCTG GCCGTTCGGC CCTTCGTCTG AGCGCAAAGG CTCCAGCACC TCCGCGGCCG AAGCCGCGGG 000080
000081 ACTTTTCGTG GAAAATGGGA CCCAGCCCGA TCGCCAGCGG CGCTGCAGCG GACTCTGCGG GAACCTAGCT TCTGCTCCAG 000160
000161 GACCTCCAGG GCCACCCCAG CTCGCAGGGC GTTCGCAGCG GCTCAGGGCG AATCACGCTC ATGGTCCCCG TGCGCATTTT 000240
000241 CAGCCCCAGC CGGTCTTTCC AGAGACACAT AGAAGGTGCC ATCTATGAGG AACAGGCCTT CACCAGACAT CAAATCTGTT 000320
000321 GGCATCTTGA TCTTTGACTT CTCCACCGCC AGAACTAGAT CAAGACATGA AACCCATGTT CAAGATACTT TCCAGTGTGT 000400
000401 CTTCATGTGA TCCTCTGAGT CCAGCCATCA GGCTACCAGC AGCTCTTGGA AACCCTGACA TACTTATTCT TAGAAGACTG 000480
000481 CTTTCCGGAC TCAAAGTGGA ACCTCAAATT TTCAATTTTC TTTGTTTTTA AAGCCTACAC ATAGGTGATG ATATATACAT 000560
000561 GCATATATAT TTTGGAGAAT TTATAATTCT GAAAACAATG CTGGTCTTAT GGAACCCATC CATTCCCCTT TCCCCGTGTG 000640
000641 TGCTCCGAGC TGTGGTGGCA CGTGAAAAGG GGTCCTTCCA GCAGTGGCCC ACAGCCCTGG GCTGCTTACT TGCTCACTTC 000720
000721 ATTTACAAGA GCAAGAAATA CACATTCTTG TGTTGTTTAA GTCATTATGA TGTGGGGATT TCCATTACTC ACACACCTGA 000800
000801 TCTAGTAGTA ACACAGTAGC CTATTTTAGC AATATCATTT ATTCAATAAT CCATTCTTTC CCCATTAGTT TTGAGCCTTC 000880
000881 ATTTATTGTG TACTAAGTTC TGGTTATTTT TAGTGGTTGT AATCTCCTTC TTTCCTACTC TCTTAATCAT GGGATTGCCA 000960
000961 ATATCTGCTC TGTGTTTCTG TGCCATCTAT AGCCTCTGGC CTTGGTACTG CTTCAAAACT GATATTTCTA ACCTTACTTT 001040
001041 GACTTCTCCA TTCAGTGAAG TTCCCATAGT TCATCACTCA ACTGCTCTCT TTCCATCGTG ACCTTCTGAA CTAGCTCACA 001120
001121 CCCAGATGTA CTTTTGTTAT CTGCCTTTCC CCCTCATAAA CATGGGCTGC TGCTGGGGAA AATCCACTAC CGAACTCTTG 001200
001201 CAGGTCTCTG CAAATGTTTA ATGCCCTGTC TTAGCCATGA CCTCCACAAT GCTGGGCTAT CCTATGTTAT GTCCCCTAAG 001280
001281 ATATCCCTTC TCTCTTACCT TTGGGGATAG TCCTAAGCTT CCATCATGGC ACTCAAAGTC CAACCTTATT TGTACCCTCA 001360
001361 TTCTCTGAGC AGACACCACC GTATTCTGTT TCACAGAGAA AATGTGACTG CTGGGGATAA TTCTTTCAAC TTCCTGGCCT 001440
001441 CTTCCTATAC ATGATCTTTC TCTGTATTCT TGCCTATTGC TCTTCCATGT TGATAGAAGT GTCTGTTCTC CTTGTCAGTG 001520
001521 TCTCGGCCTT GGATCTGTCC CCTAGACTAT TCTGCCTGTG TAAGGACCTT CCCTGACCAG CTGGGCCACC ATCTCCTGCT 001600
001601 TCTCCAATCC CTCACTCTAG ACTGACTCTT AACCTTTGGT CAACAATACT TGAGCTTTTA CATTCATAAT GGAGCATCTG 001680
001681 TGTTGAACCT TGTTCTTTTC TAGACACTAC CCTCCGTTCT GTCTTCCATC CATGGTGACT TTTCTAGAAA GAGCATCTAT 001760
001761 CACACTGGAG ACAGCAAACT CCTTGATCCA TTCTAATTCC TAACCCTGCA ATAATTTTCT ATCTCCCTTA CTCAAGTAAT 001840
001841 TGGGAGTGCT CCTAGTGTTA CCAGAGACCC AGCAGTTCCC AATTTCGAAT TTTTCCGTAT TCACATTTCT TGACTTGCTA 001920
001921 TGATTTTACA TCACAGATTA CATCCTTCAT TTGAAGAGAC TCTAATGGAA GGCTGCCATG GAAACTCTCT CATGTGGCTG 002000
002001 ACCTCCTACC TCACTTGCTC TTTCTGAATG AAGTTCCCAC TTTTGCCTGC CTTAATGAAA GTAATGCTCC CCAAACTCAA 002080
002081 GCCCAGGGCT GCGAATTGGA AGCAGCTGGG GCTACTGTTT CTGGGTGCTG GTGTGAATGG CAGGATGTGA ACACCAGCCT 002160
002161 GTGACGGGCA AAAAGATGGA CACACAGGCA GAGCCTGACA GGTGCTGGTG GTCCTATCTG GTCCTGAGTT GCTGGGACCC 002240
002241 TCCTTGCCCA CTGCCCCTAG AATGGACTTT GGCCTCAGGT TCGAAGTGTT CAGATGTGAC TGAGATGAGC CTTTTCCCCA 002320
002321 TGCCTCAGGA ATAGCGAAGA AACTCTATCT GGAAGGTTCC CCAGGCTTCC CCACCCAGCA GCCTCTGGTA TTAGACCAGG 002400
002401 CAGTGGCTGG CCAGGATGGT GGGGACAGAA GGGAGACAAA GGTGAGCAGT GGGTGGGGTC ACATCCTCCC TGACATTGAA 002480
002481 TAGACAACAT GGGGAGGAAG GATGAGTGAT CTTTAGAATG TTCATGGAAA ATGCATATTG GGAAAAAGAA TGCATGAATT 002560
002561 TCAAATTGTT TTGCAACAAA ATAAACTTGT ACTAACTTGT GAAAACACGT CCGAACAGGA TCTAGTTTGA GGCCCTAAGA 002640
002641 AGTATAAGAC AACAGTTTGA ACAGAGCTCC TATCAGACAC ATGAATTCTG CTAAAATTGA AACCAGAACA AACATGCAAT 002720
002721 TGATGGTGAA GCTTGGCTGG AAACATGGTG AAATCATTGA TGATTTATTG AAAGTTTATA GGGACAATGC CTCAAAGAAA 002800
002801 TCAGCAATTT AAGTAAGTGG ATAACTCATT GGAAGAAGAG AAGAGATGAT GTTGGAGAGG AAGTCCACAG CAGCAGGCCA 002880
002881 GCCACATCAG TCTGTGAGGA AACAATTCAT CTTGTTTGTG CCCTAATTTA AGAGGACTGA TTAATAGCAG CAGAAACAAT 002960
002961 AGCCAACGCT GTAGGTATCC CAAGGTGTTC AGCTTACACA ATTCTGACTG AAATTAAAGT TGAGTAAACT GTCCACTCGG 003040
003041 TGGGTGCCAA AACTTTCTCC CAGCTCAGCT GCAGATAAGA GAAAAGCGTT CTATGGCCAT TTTAAACAAG TGGAATCAAG 003120
003121 ATCCTGAAGC ATTTCTTCAT ATAATTATAG CCGGAGATGA AATGTGGCTT AACCAGTACA CTCCTGAAGG CAAAGCACAA 003200
003201 GCAAAGCAAT GACTACCTAG AGGTGGGCGT GGTCCCATCA GAGTAAAAGC AGACATGTCA AGGGCAAAGG TCGTGGCAAC 003280
003281 CGTTTTGTGA ATGCTCAAGG CATCTTGCTT ATTGACTTTC TGGAGGGCCA AAGAACAGTA ACATCTTATT ATGAGAGTGT 003360
003361 ATAGAGAAAG TCAGCCAACG ATTTAGCAGG AAAACACCCA GGAAATCGTC ACCCCGGAAA GCTTCACCAG AGAGCCCTTC 003440
003441 TCCACCATGA CAATGCTCCT GCTCATTCCT CTCATCAAAC AAGGCCAGTT TTGTGAGAGT TTCAATGGGA AATCACTAGG 003520
003521 CATACACCTT CCAGGCCTGA TTTGGTTACT TCTGTTTTAT AATTTTAAAA AATCTTTAAA GGGCACCCAC TTTTCTTCAG 003600
003601 TTAATAACGT CACAAAGACT GAAGTGGCAT GGTTAAATTC CCAGGGTGCC CAATTCTTTA GGGATGAACT GAATGGCTGG 003680
003681 TACCATTACT TGCAGAAGCG TCTCGACCTT GATGGAGCTC ATGCTGAGAA ATAAAACATT TTTTAATTTT TATCTTTTAA 003760
003761 TTCAATTTTT TCGTGAACTT TTGAAGTCCC CTTGTATTTG TTTTTGGTGG AACTTTGAGT CTGATTTCTC AGCTCCCCAT 003840
003841 GGATGGCTGC ATCTTAACAG AGAAATGAAC GCCATTTACC CTGATGCTCT CTACTTGGCC TAAGTTTCAG ATGTTGAACA 003920
003921 CACACGTGTG GGAATTTATG AATCTGTGCA CCTGTGCCAG CTGGTGGGTG AAGTCTAAGT TTCTTCAACA CAATTAGTTA 004000
004001 TCTTCTGCCT CCTGGAATCT GGTAGGAAAG GTTGAGGAAA AGCAGCCATC CACAGCGCCT CCACCACTGG AATGGGGGCA 004080
004081 GCCCTAACGT GTGCCCCACT GCCCCCCATG CTGAGGAGTC CTTCACTCCA GGGATGTCTT CACCCCAATC ATTCAGACTC 004160
004161 CCCCAGTGTT CCTGCGTCAC CTGAAAGGTC GGAAGCATCT CAGCACATAC TCTCCATGAG TGGTACTTAG GCCTCCCTCC 004240
004241 CCATCAATAC TGAAGCCCTC AGAGGCAGAG GGGAGTCAAG GAAAAGAGTG GCCATCAGCA ATAAATGAGT TACAAGGTTT 004320
004321 GATTTCAAAG AGAAAAACTT GTCACCAAAA TCACTACTCA GGAGATCTGG ACTTCCTCTG AATGTGAGTT AAAGAACCCT 004400
004401 TGAGGGTTAA GAGCCAACTG CACCTGATCC CCACTCTCCC ATCCCAAGAC CCTGGGAAGT CAAACCAAGA GGTAATCAAC 004480
004481 AGAAAACAAG TTTAATGCAA CAGGTGACAA CGGTCTGGAG CGAGTCCATG CTCCGGAAGG CTCAGTCTGT GGCAGTCCCG 004560
004561 TGGCTCAAGA CAGGCTGAGG CCGGCTGCAA TGGAGGCCAG CAGCAGGAGG ATGGCCAGCC ACAGCCCACC ACAGCTCTCA 004640
004641 CCCATGCTCC CAGCATATTC TTTGAACACT GATGAGTTGA TAGGTGGCCC CTCTAAATTG CAGTAGCGAA TTTTACAACA 004720
004721 CTTGAGGTAA AAGAAGGGCA TGGGCTCTTC CAGGAGAAAC CGCTTCTCCT CTGGCTTGGG TCTCTCCATC GCTGCACAAC 004800
004801 CAGCGGAGCA CTGCTTCGCA ACCATGAAAA AACGTGGAAA TATTTCTAAT AGGAAATAAA GACCGAGAGA AGGCAATCAC 004880
004881 GCAATTCCAA TGCCTGACAC CGAGGCCCTT CTGTCTGGGT CAAAGCCTCA CCCCTGGCGG CCCTGCTCAA AGGTGCACAG 004960
004961 TCAACTGGGG CACCAAGGGG GAGTCGGGAG GACGAGGGCC AGGCCTGTGT GTTGAATGCT GCTTCAGGGA AGGGCTGGCT 005040
005041 TCTGCGTGGT ATGGCCTGTC CATATGCACT GGGAATGCGG GTCTAGGGGT TGCTGTTTGG GAACAAACAG GTCTCAACTT 005120
005121 CTCAAACACA GGGTTGGCTC AGGCCTTTGT GACCACAGAC AGACACATGA CTCCCAGCCA TTCTGGCCAT CACCCAGGGT 005200
005201 GTGGAGCTGG CCTCTTGGTG GGCCTGGCTC GACTCTGAGC TGGGGGTCTT GTCTCATGAC CACACTTCAT CTTATACATC 005280
005281 ACTGTACAAA TCATTTTGCC ATATTAAGTT ATAAAGTCGA TGTGGGCCAC ACTGAGTCTG AAGCATCACC TCAGCACCCC 005360
005361 ACCAACTTCG TGGATACCGA AGGGCTGGAG AGTGACTGCT GGGCGGAATC AGAATTCACG AGCCCTGAAG ATCTCCCTGT 005440
005441 GGGCAGAATG TGCTGGGTGT CCAGATTCCC CTTGGGGAGG GCTTCATGTA CCCAGAGGTT TTCAGGGGAA TCACAGATGA 005520
005521 CAGAGCAGTG GTCTCCACAA TTTTTAAGGC ATGCACCCTC CTTTGAGAAC ACACTTGAAG GCTGTACACC TTGGTTTTGT 005600
005601 GCATCTCTTG TAAGAGTGAC ATAGACACTG TTCTCTGTGG CGCATTTAAC ACTATTAAAG CTTAATTTTT CATTTAAAAA 005680
005681 TGGA