LNCAROD
LNCAROD, Long ncRNA activates its target gene DKK1 at its release from chromatin
Contents
Annotated Information
Approved Symbol
LNCAROD
Approved Name
LNCAROD: lncRNA activating regulator of DKK1 lnc-MBL2-4, A-ROD, LINC01468
Characteristics
LNCAROD is transcribed 130 kb downstream of Dickkopf homolog 1 (DKK1) on the opposite strand on chromosome 10q21.1 [1]. LNCAROD is a relatively highly expressed, multi-exonic and poly adenylated long ncRNA [1].
Function
LNCAROD is a tissue-specific regulator of DKK1 expression [1]. Upon LNCAROD knock-down there is a significant increase in the transcription pausing index at the DKK1 locus in agreement with LNCAROD being involved in transcriptional enhancement of DKK1 [1].
Regulation
The promoter of LNCAROD in MDA-MB-231 cells when methylated does not show characteristics of active transcription as opposed to MCF-7 cells where the promoter is hypo-methylated and A-ROD is actively expressed [1].
Diseases
- Tongue Squamous Cell Carcinoma [2].
Expression
The expression of LNCAROD in MCF-7 cells is high compared to other cell lines and generally shows an expression restricted to epithelial and endothelial cells (NHEK and HMEC) expressed lncRNAs were identified [1]. LNCAROD was upregulated in the micro-dissected tongue SCC tissues [1].
Labs working on this lncRNA
- Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Kowloon, Hong Kong
- Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
- Free University Berlin, 14195 Berlin, Germany
- Humboldt University, 10115 Berlin, Germany
- Institute for Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Ntini E, Louloupi A, Liz J, Muino JM, Marsico A & Orom UAV. Long ncRNA A-ROD activates its target gene DKK1 at its release from chromatin[J]. Nat Commun. 2018
- ↑ Gao W, Chan JYW & Wong TS. Long Non-Coding RNA Deregulation in Tongue Squamous Cell Carcinoma[J]. Biomed Res Int. 2014.
Sequence
>gi|101928687|ref|NR_120641.1|Homo sapiens lncRNA activating regulator of DKK1 (LNCAROD), transcript variant 1, long non-coding RNA
000081 GTACCCTTCA AGCAGCCCTG GAGAGTTTAT CTCTGCATGC TGGAGCTAAT AATAATAGAA TCTCAAGAGC CTTCAAACAT 000160
000161 CCATATTATG CTGATGTCTT TTAAGGTGAT TCAACTCAGC ATATGTTGTT TGAAGCCGTG AGACTGAGTG AGATCATGGA 000240
000241 GGAAGTGAAT GTAAATAGAA AAGGGAAGAA GTCTGAAGAC GGAGCCCTGA GACACTCCAT TGTAAACTGG AAGATGAGGA 000320
000321 AGAGCCAGCA AAGGAGACTG AGAAGGGGCA GCCAGTGAAG ATGGAGCCAG GGCTAGAGTA AGAGCCCCTT CTGGGATGCT 000400
000401 GTGACCCCCA AGTTTGAAGA CTGCTGATAA CCCCAATCTA CGAAGACTAG CTATGGAACT TCCTACACTG AGACAACTCC 000480
000481 AGTGGAACTC TGATAATTAT CCTAAAATAA GGAGGCTTCT TCAGTAGCCC TCGAAATATG TTCAAATACA TGATTACATT 000560
000561 TATGTCCTTA ATATTGCTAT TAGTTTCTGA TGTTAATGTA AAAGTTGGGG AAAAAGTGGA AAAGTTAAAG CAGTGCAGGT 000640
000641 TAATTCAATG CCAGAGTAAC TTCTCAGAGG GTGTATATTC AGTGTGAACA ATTTTCAACA GAGAAATGTC AACTTCTGGC 000720
000721 CACAACGGCA ACCAGTAAAA TGACTATTTT TACTGTCTTA TCTATTAATG AAGAGGAGAT TGCATAATAT AGATGAAGGA 000800
000801 GCATAGTATT TGCAGGTGGA ACGCCTAGCA GGGCTTGAGT CTCAACTCTG CTGCTTTTAC TCTAATTGAC CGAGACAAGT 000880
000881 CATTTAAACT AATAGAGCTT CAATTTTCTC ATATCTAATG TAACATAACA ATTCACAGCC TTTTACTTTG TAGTTATCGT 000960
000961 GAAGATCTAA TCGCAGTGAA ATATATTTAT ATATCTGTCT GCTGATA
